Senaste publikationer

Polygenic prediction of body mass index and obesity through the life course and across ancestries. Smit RAJ, Wade KH, Hui Q, Arias JD, Yin X, Christiansen MR, Yengo L, Preuss MH, Nakabuye M, Rocheleau G, Graham SE, Buchanan VL, Chittoor G, Graff M, Guindo-Martínez M, Lu Y, Marouli E, Sakaue S, Spracklen CN, Vedantam S, Wilson EP, Chen SH, Ferreira T, Ji Y, Karaderi T, Lüll K, Machado M, Malden DE, Medina-Gomez C, Moore A, Rüeger S, Akiyama M, Allison MA, Alvarez M, Andersen MK, Appadurai V, Arbeeva L, Bartell E, Bhaskar S, Bielak LF, Bis JC, Bollepalli S, Bork-Jensen J, Bradfield JP, Bradford Y, Brandl C, Braund PS, Brody JA, Broeckel U, Burgdorf KS, Cade BE, Cai Q, Camarda S, Campbell A, Cañadas-Garre M, Chai JF, Chesi A, Choi SH, Christofidou P, Couture C, Cuellar-Partida G, Danning R, Degenhardt F, Delgado GE, Delitala A, Demirkan A, Deng X, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Eichelmann F, Eliasen AU, Engmann JE, Erdos MR, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Frank M, Freitag-Wolf S, Fritsche LG, Fuchsberger C, Galesloot TE, Gao Y, Geller F, Giannakopoulou O, Giulianini F, Gjesing AP, Goel A, Gordon SD, Gorski M, Grove J, Guo X, Gustafsson S, Haessler J, Hansen TF, Havulinna AS, Haworth SJ, Heard-Costa N, Hemerich D, Highland HM, Hi…See abstract for full author list ➔ Nat Med. 2025 Jul 21. doi: 10.1038/s41591-025-03827-z. Online ahead of print.

No evidence from euglycaemic-hyperinsulinaemic clamp studies for greater insulin sensitivity in adults with type 1 diabetes using insulin pump versus multiple daily insulin injections-Post hoc meta-analysis. Januszewski AS, Snaith JR, Grzelka-Wozniak A, Simonsen JRA, Sachithanandan N, Ward GM, O’Neal DN, Gordin D, Thorn LM, Groop PH, Uruska AA, Zozulinska-Ziolkiewicz DA, Jenkins AJ, Greenfield JR. Diabetes Obes Metab. 2025 Jul 1. doi: 10.1111/dom.16487. Online ahead of print.

Tirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT-MMO trial. Lam CSP, Rodriguez A, Aminian A, Ferrannini E, Heerspink HJL, Jastreboff AM, Laffin LJ, Pandey A, Ray KK, Ridker PM, Sanyal AJ, Yki-Jarvinen H, Mason D, Strzelecki M, Bartee AK, Cui C, Hurt K, Linetzky B, Bunck MC, Nissen SE. Obesity (Silver Spring). 2025 Jun 22. doi: 10.1002/oby.24332. Online ahead of print.

Genetic Loci Associated With Periodontitis: The FinnGen Study Based on National Health Registers. Salminen A, Hyvärinen K, Ritari J, Caetano A, Kambur O, Mäntylä P, Yilmaz M, Sinisalo J; FinnGen; Perola M, Havulinna A, Nibali L, Gürsoy UK, Pussinen PJ. J Clin Periodontol. 2025 Jul 19. doi: 10.1111/jcpe.14193. Online ahead of print.

Sympathetic activation of adipose tissue lipolysis underlies overnutrition-induced metabolic dysfunction. Luukkonen PK. J Hepatol. 2025 Jun 18:S0168-8278(25)02252-4. doi: 10.1016/j.jhep.2025.05.021. Online ahead of print.

Impact of different hypertensive disorders of pregnancy on cardiovascular disease risk and all-cause mortality in women with type 1 diabetes. Rimpeläinen K, Jansson Sigfrids F, Gordin D, Klemetti MM, Harjutsalo V, Groop PH, Thorn LM; FinnDiane Study Group. Cardiovasc Diabetol. 2025 Jun 14;24(1):255. doi: 10.1186/s12933-025-02804-7.

A proteomic signature of healthspan. Kuo CL, Liu P, Drouard G, Vuoksimaa E, Kaprio J, Ollikainen M, Chen Z, Pilling LC, Atkins JL, Fortinsky RH, Kuchel GA, Diniz BS. Proc Natl Acad Sci U S A. 2025 Jun 10;122(23):e2414086122.

Cardiometabolic health 8-12 years after pre-eclampsia: Role of obesity and gestational diabetes (FINNCARE study). Kivelä A, Renlund-Vikström M, Heinonen S, Sarkola T, Laivuori H, Jääskeläinen T. Pregnancy Hypertens. 2025 Jun 9;41:101226. doi: 10.1016/j.preghy.2025.101226. Online ahead of print.

Genome-wide interaction study with BMI identifies CYP7A1 and GIPR as genetic modulators of MASLD. Jamialahmadi O, Mujica E, Morris L, Mancina RM, Ciociola E, Qadri SF, Maurotti S, Malvestiti F, Li-Gao R, Ronzoni L, Tavaglione F, Maude H, Allalou A, Emmanouilidou A, Vespasiani-Gentilucci U, Rosendaal FR, Yki-Järvinen H, Cebola I, Valenti L, den Hoed M, Romeo S. Clin Mol Hepatol. 2025 Jun 2. doi: 10.3350/cmh.2025.0159. Online ahead of print.

Protein Associations With Alcohol Consumption and Genetic Risk for Alcohol-Related Sociomedical Conditions. Drouard G, Palviainen T, Kuo CL, Diniz BS, Wang X, Ollikainen M, Latvala A, Kaprio J. Addict Biol. 2025 Jun;30(6):e70045. doi: 10.1111/adb.70045.

Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration. Jacques M, Landen S, Sharples AP, Garnham A, Schittenhelm R, Steele J, Heikkinen A, Sillanpää E, Ollikainen M, Broatch J, Zarekookandeh N, Hanson O, Ekström O, Asplund O, Lamon S, Alexander SE, Smith C, Bauer C, Woessner MN, Levinger I, Teschendorff AE, Gillberg L, Blom I, Helge JW, Harvey NR, Haupt LM, Griffiths LR, Deshmukh AS, Pietiläinen KH, Piirilä P, Seaborne RAE, Klevjer M, Bye A, Wisløff U, Jones-Freeman B, Eynon N. Cell Rep. 2025 Jun 24;44(6):115750. doi: 10.1016/j.celrep.2025.115750. Epub 2025 May 28.

Twin Study Provides Heritability Estimates for 2321 Plasma Proteins and Assesses Missing SNP Heritability. Drouard G, Hagenbeek FA, Ollikainen M, Zheng Z, Wang X; FinnGen; Ripatti S, Pirinen M, Kaprio J. J Proteome Res. 2025 Jun 6;24(6):2689-2697. doi: 10.1021/acs.jproteome.4c00971. Epub 2025 May 27.

Pediatric heart transplantation within the Scandiatransplant region-a multinational observational study spanning 38 years. van der Have O, Tran-Lundmark K, Wåhlander H, Kaskinen AK, Möller T, Juul K, Jahnukainen T, Weinreich ID, Sarkola T, Nilsson J, Odermarsky M. J Heart Lung Transplant. 2025 Jun 5:S1053-2498(25)02024-8. doi: 10.1016/j.healun.2025.05.020. Online ahead of print.

Tricaine, eugenol and etomidate for repetitive procedural anesthesia in adult zebrafish, Danio rerio: effect on stress and behavior. Narumanchi S, Perttunen S, Laine P, Kosonen R, Lakkisto P, Laine M, Tikkanen I, Paavola J. Front Vet Sci. 2025 May 14;12:1562425. doi: 10.3389/fvets.2025.1562425. eCollection 2025.

Genome-wide association study of anterior uveitis. Koskimäki F, Ahokas O, Kajanne R, Saviauk KR, Elnahas A, Reigo A, Reis K, Esko T, Palta P, Leinonen S, Kettunen J, Liinamaa J, Karjalainen MK, Saarela V; Estonian Biobank Research Team Consortium, FinnGen Consortium; FinnGen Consortium. Br J Ophthalmol. 2025 May 30;109(6):660-667. doi: 10.1136/bjo-2024-326037.

Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity. Heikkinen A, Esser VFC, Lee SHT, Lundgren S, Hakkarainen A, Lundbom J, Kuula J, Groop PH, Heinonen S, Villicaña S, Bell JT, Maguolo A, Nilsson E, Ling C, Vaag A, Pajukanta P, Kaprio J, Pietiläinen KH, Li S, Ollikainen M. Nat Commun. 2025 May 12;16(1):4374. doi: 10.1038/s41467-025-59576-7.

Proteomic associations with fluctuation and long-term changes in BMI: A 40-year follow-up study. Obeso A, Drouard G, Palviainen T, Wang X, Ollikainen M, Silventoinen K, Kaprio J. Diabetes Obes Metab. 2025 Aug;27(8):4192-4202. doi: 10.1111/dom.16448. Epub 2025 May 8.

Multi-Omic Associations of Epigenetic Age Acceleration Are Heterogeneously Shaped by Genetic and Environmental Influences. Drouard G, Suhonen S, Heikkinen A, Wang Z, Kaprio J, Ollikainen M. Aging Cell. 2025 May 5:e70088. doi: 10.1111/acel.70088. Online ahead of print.

Progression of Cerebral Small Vessel Disease Among Neurologically Asymptomatic Middle-Aged Individuals With Type 1 Diabetes. Tarkkonen A, Kyläheiko I, Inkeri J, Eriksson MI, Thorn LM, Summanen PA, Tatlisumak T, Groop PH, Putaala J, Gordin D, Martola J; FinnDiane Study Group. Diabetes Care. 2025 May 1;48(5):776-780. doi: 10.2337/dc24-1825.

Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease. Martiskainen H, Willman RM, Harju P, Heikkinen S, Heiskanen M, Müller SA, Sinisalo R, Takalo M, Mäkinen P, Kuulasmaa T, Pekkala V, Galván Del Rey A, Juopperi SP, Jeskanen H, Kervinen I, Saastamoinen K; FinnGen; Niiranen M, Heikkinen SV, Kurki MI, Marttila J, Mäkinen PI, Rostalski H, Hietanen T, Ngandu T, Lehtisalo J, Bellenguez C, Lambert JC, Haass C, Rinne J, Hakumäki J, Rauramaa T, Krüger J, Soininen H, Haapasalo A, Lichtenthaler SF, Leinonen V, Solje E, Hiltunen M. Mol Neurodegener. 2025 Apr 29;20(1):50. doi: 10.1186/s13024-025-00830-3.

Risk stratification beyond fibrosis in SLD: The case for lifestyle-responsive prognostic tools. Åberg F, Asteljoki JV, Luukkonen PK. J Hepatol. 2025 Aug;83(2):e91-e92. doi: 10.1016/j.jhep.2025.04.024. Epub 2025 Apr 22.

Nuclear envelope-associated lipid droplets are enriched in cholesteryl esters and increase during inflammatory signaling. Szkalisity Á, Vanharanta L, Saito H, Vörös C, Li S, Isomäki A, Tomberg T, Strachan C, Belevich I, Jokitalo E, Ikonen E. EMBO J. 2025 May;44(10):2774-2802. doi: 10.1038/s44318-025-00423-2. Epub 2025 Apr 7.

Evidence-based criteria for identifying at-risk individuals requiring liver disease screening. Åberg F, Männistö V, Asteljoki J, Salomaa V, Jula A, Lundqvist A, Männistö S, Perola M, Luukkonen PK. Hepatol Commun. 2025 Mar 21;9(4):e0679. doi: 10.1097/HC9.0000000000000679. eCollection 2025 Apr 1.

Subtypes of MASLD confer distinct clinical trajectories. Luukkonen PK. J Hepatol. 2025 Jun;82(6):1138-1139. doi: 10.1016/j.jhep.2025.02.032. Epub 2025 Mar 17.

Metabolic dysfunction-associated steatotic liver disease in adults. Huang DQ, Wong VWS, Rinella ME, Boursier J, Lazarus JV, Yki-Järvinen H, Loomba R. Nat Rev Dis Primers. 2025 Mar 6;11(1):14. doi: 10.1038/s41572-025-00599-1.

Hidden metabolic effects of acetyl-CoA carboxylase inhibition. Luukkonen PK. J Hepatol. 2025 Mar;82(3):544-545. doi: 10.1016/j.jhep.2024.11.043. Epub 2024 Dec 16.

Function of PNPLA3 I148M-Lessons From In Vivo Studies in Humans. Yki-Järvinen H, Luukkonen PK. Liver Int. 2025 Apr;45(4):e70047. doi: 10.1111/liv.70047.

Circulating levels of miR-20b-5p are associated with survival in cardiogenic shock. Mäntylä T, Wang C, Hänninen M, Immonen K, Jäntti T, Lassus J, Tikkanen I, Pulkki K, Devaux Y, Harjola VP, Lakkisto P; CardShock Study Investigators. J Mol Cell Cardiol Plus. 2025 Jan 17;11:100284. doi: 10.1016/j.jmccpl.2025.100284. eCollection 2025 Mar.

Proteomic profiling reveals alterations in metabolic and cellular pathways in severe obesity and following metabolic bariatric surgery. Dadson P, Honka MJ, Suomi T, Haridas PAN, Rokka A, Palani S, Goltseva E, Wang N, Roivainen A, Salminen P, James P, Olkkonen VM, Elo LL, Nuutila P. Am J Physiol Endocrinol Metab. 2025 Mar 1;328(3):E311-E324. doi: 10.1152/ajpendo.00220.2024. Epub 2025 Jan 17.

Insight into the function of the Golgi membrane protein GOLM1 in cholangiocytes through interactomic analysis. Nagaraj M, Emmagouni SKG, Chaurasiya V, Li L, Nguyen VD, Keskitalo S, Varjosalo M, Zhou Y, Haridas PAN, Olkkonen VM. FEBS Lett. 2025 Feb 1. doi: 10.1002/1873-3468.70001. Online ahead of print.

The role of Nir2, a lipid-transfer protein, in regulating endothelial cell functions. Polianskyte-Prause Z, Arora A, Taskinen JH, Chaurasiya V, Keskitalo S, Tuhkala A, Hilska I, Varjosalo M, Olkkonen VM. Biochim Biophys Acta Mol Cell Res. 2025 Feb 25;1872(3):119926. doi: 10.1016/j.bbamcr.2025.119926. Online ahead of print.

Age at type 1 diabetes onset does not influence attained brain volume. Claesson TB, Mutter S, Putaala J, Salli E, Gordin D, Groop PH, Martola J, Thorn LM. BMC Endocr Disord. 2025 Feb 18;25(1):43. doi: 10.1186/s12902-025-01868-6.

A proteomic signature of healthspan. Kuo CL, Liu P, Drouard G, Vuoksimaa E, Kaprio J, Ollikainen M, Chen Z, Pilling LC, Atkins JL, Fortinsky RH, Kuchel GA, Diniz BS. medRxiv [Preprint]. 2025 Jan 28:2024.06.26.24309530. doi: 10.1101/2024.06.26.24309530.

Suboptimal dietary patterns are associated with accelerated biological aging in young adulthood: A study with twins. Ravi S, Kankaanpää A, Bogl LH, Heikkinen A, Pietiläinen KH, Kaprio J, Ollikainen M, Sillanpää E. Clin Nutr. 2025 Feb;45:10-21. doi: 10.1016/j.clnu.2024.12.018. Epub 2024 Dec 19.

Glycemic control in women with GDM: insights from a randomized controlled pilot trial on plant-based Nordic healthy diet versus moderately carbohydrate restricted diet. Markussen LT, Kivelä J, Lindström J, Ollikainen M, Kytö M, Heinonen S, Koivusalo S, Meinilä J. BMC Nutr. 2025 Jan 16;11(1):12. doi: 10.1186/s40795-024-00988-x.

Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits. Brotman SM, El-Sayed Moustafa JS, Guan L, Broadaway KA, Wang D, Jackson AU, Welch R, Currin KW, Tomlinson M, Vadlamudi S, Stringham HM, Roberts AL, Lakka TA, Oravilahti A, Fernandes Silva L, Narisu N, Erdos MR, Yan T, Bonnycastle LL, Raulerson CK, Raza Y, Yan X, Parker SCJ, Kuusisto J, Pajukanta P, Tuomilehto J, Collins FS, Boehnke M, Love MI, Koistinen HA, Laakso M, Mohlke KL, Small KS, Scott LJ. Nat Genet. 2025 Jan;57(1):180-192. doi: 10.1038/s41588-024-01982-6. Epub 2025 Jan 2.

LAPTM4B counteracts ferroptosis via suppressing the ubiquitin-proteasome degradation of SLC7A11 in non-small cell lung cancer. Yan R, Liu D, Guo H, Liu M, Lv D, Björkblom B, Wu M, Yu H, Leng H, Lu B, Li Y, Gao M, Blom T, Zhou K. Cell Death Dis. 2024 Jun 20;15(6):436. doi: 10.1038/s41419-024-06836-x.

Transcriptomic and Metabolomic Analyses in Monozygotic and Dizygotic Twins. Hubers N, Drouard G, Jansen R, Pool R, Hottenga JJ, Ollikainen M, Wang X, Willemsen G, Kaprio J, Boomsma DI, van Dongen J. Am J Med Genet A. 2024 Dec 16:e63971. doi: 10.1002/ajmg.a.63971. Online ahead of print.

SMIM1 absence is associated with reduced energy expenditure and excess weight. Stefanucci L, Moslemi C, Tomé AR, Virtue S, Bidault G, Gleadall NS, Watson LPE, Kwa JE, Burden F, Farrow S; DBDS Genetic Consortium; Chen J; MAGIC; Võsa U, Burling K, Walker L, Ord J, Barker P, Warner J, Frary A, Renhstrom K, Ashford SE, Piper J, Biggs G, Erber WN, Hoffman GJ, Schoenmakers N, Erikstrup C, Rieneck K, Dziegiel MH, Ullum H, Azzu V, Vacca M, Aparicio HJ, Hui Q, Cho K, Sun YV, Wilson PW, Bayraktar OA, Vidal-Puig A, Ostrowski SR, Astle WJ, Olsson ML, Storry JR, Pedersen OB, Ouwehand WH, Chatterjee K, Vuckovic D, Frontini M. Med. 2024 Sep 13;5(9):1083-1095.e6. doi: 10.1016/j.medj.2024.05.015. Epub 2024 Jun 20.

Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease. Raverdy V, Tavaglione F, Chatelain E, Lassailly G, De Vincentis A, Vespasiani-Gentilucci U, Qadri SF, Caiazzo R, Verkindt H, Saponaro C, Kerr-Conte J, Baud G, Marciniak C, Chetboun M, Oukhouya-Daoud N, Blanck S, Vandel J, Olsson L, Chakaroun R, Gnemmi V, Leteurtre E, Lefebvre P, Haas JT, Yki-Järvinen H, Francque S, Staels B, Le Roux CW, Tremaroli V, Mathurin P, Marot G, Romeo S, Pattou F. Nat Med. 2024 Dec;30(12):3624-3633. doi: 10.1038/s41591-024-03283-1. Epub 2024 Dec 9.

Hidden metabolic effects of acetyl-CoA carboxylase inhibition. Luukkonen PK. J Hepatol. 2024 Dec 16:S0168-8278(24)02745-4. doi: 10.1016/j.jhep.2024.11.043. Online ahead of print.

The Value of Repeat 5-HIAA Measurements as a Predictor of Carcinoid Heart Disease: A Prospective 5-Year Follow-Up Study in Patients with Small Intestinal Neuroendocrine Tumors. Kostiainen I, Simonen P, Aaltonen K, Lindén R, Karppinen N, Gordin D, Rapola J, Schalin-Jäntti C, Matikainen N. Cancers (Basel). 2024 Nov 21;16(23):3896. doi: 10.3390/cancers16233896.

A metabolome-derived score predicts metabolic dysfunction-associated steatohepatitis and mortality from liver disease. Huang Q, Qadri SF, Bian H, Yi X, Lin C, Yang X, Zhu X, Lin H, Yan H, Chang X, Sun X, Ma S, Wu Q, Zeng H, Hu X, Zheng Y, Yki-Järvinen H, Gao X, Tang H, Xia M. J Hepatol. 2024 Oct 16:S0168-8278(24)02636-9. doi: 10.1016/j.jhep.2024.10.015. Online ahead of print.

Pre-diagnosis blood DNA methylation profiling of twin pairs discordant for breast cancer points to the importance of environmental risk factors. Bode HF, He L, Hjelmborg JVB, Kaprio J, Ollikainen M. Clin Epigenetics. 2024 Nov 18;16(1):160. doi: 10.1186/s13148-024-01767-y.

PCSK9 Antibodies Treatment Specifically Enhances the Macrophage-specific Reverse Cholesterol Transport Pathway in Heterozygous Familial Hypercholesterolemia. Borràs C, Canyelles M, Girona J, Ibarretxe D, Santos D, Revilla G, Llorente-Cortes V, Rotllan N, Kovanen PT, Jauhiainen M, Lee-Rueckert M, Masana L, Arrieta F, Martínez-Botas J, Gómez-Coronado D, Ribalta J, Tondo M, Blanco-Vaca F, Escolà-Gil JC. JACC Basic Transl Sci. 2024 Aug 28;9(10):1195-1210. doi: 10.1016/j.jacbts.2024.06.008. eCollection 2024 Oct.

Circulating hsa-miR-320a and its regulatory network in type 1 diabetes mellitus. Nizam R, Malik MZ, Jacob S, Alsmadi O, Koistinen HA, Tuomilehto J, Alkandari H, Al-Mulla F, Thanaraj TA. Front Immunol. 2024 Oct 11;15:1376416. doi: 10.3389/fimmu.2024.1376416. eCollection 2024.

Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations. Salo V, Määttä J, Sliz E; FinnGen; Reimann E, Mägi R; Estonian Biobank Research Team; Reis K, Elhanas AG, Reigo A, Palta P, Esko T, Karppinen J, Kettunen J. Nat Commun. 2024 Nov 7;15(1):9424. doi: 10.1038/s41467-024-53467-z.

A sham-controlled randomised pilot trial on baroreflex activation therapy in patients with resistant hypertension: What will the future hold? Gordin D, Simonsen R, Tikkanen I. Blood Press. 2024 Dec;33(1):2417887. doi: 10.1080/08037051.2024.2417887. Epub 2024 Oct 23.

The role of dietary modification in the prevention and management of metabolic dysfunction-associated fatty liver disease: An international multidisciplinary expert consensus. Zeng XF, Varady KA, Wang XD, Targher G, Byrne CD, Tayyem R, Latella G, Bergheim I, Valenzuela R, George J, Newberry C, Zheng JS, George ES, Spearman CW, Kontogianni MD, Ristic-Medic D, Peres WAF, Depboylu GY, Yang W, Chen X, Rosqvist F, Mantzoros CS, Valenti L, Yki-Järvinen H, Mosca A, Sookoian S, Misra A, Yilmaz Y, Kim W, Fouad Y, Sebastiani G, Wong VW, Åberg F, Wong YJ, Zhang P, Bermúdez-Silva FJ, Ni Y, Lupsor-Platon M, Chan WK, Méndez-Sánchez N, de Knegt RJ, Alam S, Treeprasertsuk S, Wang L, Du M, Zhang T, Yu ML, Zhang H, Qi X, Liu X, Pinyopornpanish K, Fan YC, Niu K, Jimenez-Chillaron JC, Zheng MH. Metabolism. 2024 Dec;161:156028. doi: 10.1016/j.metabol.2024.156028. Epub 2024 Sep 11.

Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles. Drouard G, Wang Z, Heikkinen A, Foraster M, Julvez J, Kanninen KM, van Kamp I, Pirinen M, Ollikainen M, Kaprio J.Sci Rep. 2024 Sep 11;14(1):21261. doi: 10.1038/s41598-024-72354-7.

A novel long non-coding RNA connects obesity to impaired adipocyte function. Lluch A, Latorre J, Oliveras-Cañellas N, Fernández-Sánchez A, Moreno-Navarrete JM, Castells-Nobau A, Comas F, Buxò M, Rodríguez-Hermosa JI, Ballester M, Espadas I, Martin-Montalvo A, Zhang B, Zhou Y, Burkhardt R, Höring M, Liebisch G, Castellanos-Rubio A, Santin I, Kar A, Laakso M, Pajukanta P, Olkkonen VM, Fernández-Real JM, Ortega FJ.Mol Metab. 2024 Oct 1:102040. doi: 10.1016/j.molmet.2024.102040. Online ahead of print.

CNPY2 protects against ER stress and is expressed by corticostriatal neurons together with CTIP2 in a mouse model of Huntington’s disease. Scordino M, Stepanova P, Srinivasan V, Pham DD, Eriksson O, Lalowski M, Mudò G, Di Liberto V, Korhonen L, Voutilainen MH, Lindholm D.Front Mol Neurosci. 2024 Sep 18;17:1473058. doi: 10.3389/fnmol.2024.1473058. eCollection 2024.

Cholesterol binding to VCAM-1 promotes vascular inflammation. Kennelly JP, Xiao X, Gao Y, Kim S, Hong SG, Villanueva M, Ferrari A, Vanharanta L, Nguyen A, Nagari RT, Burton NR, Tol MJ, Becker AP, Lee MJ, Ikonen E, Backus KM, Mack JJ, Tontonoz P.bioRxiv [Preprint]. 2024 Sep 18:2024.09.17.613543. doi: 10.1101/2024.09.17.613543.

Altered oxidant and antioxidant levels are associated with vascular stiffness and diabetic kidney disease in type 1 diabetes after exposure to acute and chronic hyperglycemia. Adeshara K, Di Marco E, Bordino M, Gordin D, Bernardi L, Cooper ME, Groop PH; FinnDiane Study Group.Cardiovasc Diabetol. 2024 Sep 28;23(1):350. doi: 10.1186/s12933-024-02427-4.

Genetic susceptibility to acute viral bronchiolitis. Pasanen A, Karjalainen MK, Korppi M, Hallman M, Rämet M; Research Project FinnGen.J Infect Dis. 2024 Sep 20:jiae467. doi: 10.1093/infdis/jiae467. Online ahead of print.

Protein Phosphatase 1 Regulatory Subunit 3 Beta rs4240624 Genotype Is Associated With Gallstones and With Significant Changes in Bile Lipidome. Männistö VT, Kaminska D, Haal S, Asteljoki J, Luukkonen PK, Käkelä P, Tavaglione F, van Weeghel M, Neuvonen M, Niemi M, Romeo S, Nieuwdorp M, Pihlajamäki J, Groen AK. Gastro Hep Adv. 2024 Mar 12;3(5):594-601. doi: 10.1016/j.gastha.2024.03.005. eCollection 2024.

Cardiac Structure and Function in 8- to 12-Year-Old Children Following In-Utero Exposure to Preeclampsia (FINNCARE Study). Renlund-Vikström M, Jääskeläinen TJ, Kivelä A, Heinonen S, Laivuori H, Sarkola T. J Am Heart Assoc. 2024 Aug 6;13(15):e034494. doi: 10.1161/JAHA.124.034494. Epub 2024 Jul 16.

A Bivariate Twin Study of Lifetime cannabis Initiation and Lifetime Regular Tobacco Smoking Across Three Different Countries. Zellers S, van Dongen J, Maes HHM, Ollikainen M, Fang F, Vrieze S, Kaprio J, Boomsma DI. Behav Genet. 2024 Sep;54(5):375-385. doi: 10.1007/s10519-024-10190-1. Epub 2024 Jul 30.

Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult. Di Nunzio G, Hellberg S, Zhang Y, Ahmed O, Wang J, Zhang X, Björck HM, Chizh V, Schipper R, Aulin H, Francis R, Fagerberg L, Gisterå A, Metso J, Manfé V, Franco-Cereceda A, Eriksson P, Jauhiainen M, Hagberg CE, Olofsson PS, Malin SG. Nat Cardiovasc Res. 2024 Mar;3(3):356-371.

Fluid bolus increases plasma hyaluronan concentration compared to follow-up strategy without a bolus in oliguric intensive care unit patients. Serlo M, Inkinen N, Lakkisto P, Valkonen M, Pulkkinen A, Selander T, Pettilä V, Vaara ST. Sci Rep. 2024 Sep 6;14(1):20808. doi: 10.1038/s41598-024-71670-2.

Circulating microRNAs targeting coagulation and fibrinolysis in patients with severe COVID-19. Helin TA, Lemponen M, Immonen K, Lakkisto P, Joutsi-Korhonen L. Thromb J. 2024 Sep 5;22(1):80. doi: 10.1186/s12959-024-00649-w.

Guidelines for mitochondrial RNA analysis. Jusic A, Erpapazoglou Z, Dalgaard LT, Lakkisto P, de Gonzalo-Calvo D, Benczik B, Ágg B, Ferdinandy P, Fiedorowicz K, Schroen B, Lazou A, Devaux Y; EU-CardioRNA COST Action CA17129; AtheroNET COST Action CA21153. Mol Ther Nucleic Acids. 2024 Jun 26;35(3):102262. doi: 10.1016/j.omtn.2024.102262. eCollection 2024 Sep 10.

Soybean oil-based HFD induces gut dysbiosis that leads to steatosis, hepatic inflammation and insulin resistance in mice. Jacob T, Sindhu S, Hasan A, Malik MZ, Arefanian H, Al-Rashed F, Nizam R, Kochumon S, Thomas R, Bahman F, Shenouda S, Wilson A, Akther N, Al-Roub A, Abukhalaf N, Albeloushi S, Abu-Farha M, Al Madhoun A, Alzaid F, Thanaraj TA, Koistinen HA, Tuomilehto J, Al-Mulla F, Ahmad R. Front Microbiol. 2024 Aug 6;15:1407258. doi: 10.3389/fmicb.2024.1407258. eCollection 2024.

Analysis of early-pregnancy metabolome in early- and late-onset gestational diabetes reveals distinct associations with maternal overweight. Masalin S, Klåvus A, Rönö K, Koistinen HA, Koistinen V, Kärkkäinen O, Jääskeläinen TJ, Klemetti MM. Diabetologia. 2024 Jul 31. doi: 10.1007/s00125-024-06237-x. Online ahead of print.

Gut Dysbiosis Shaped by Cocoa Butter-Based Sucrose-Free HFD Leads to Steatohepatitis, and Insulin Resistance in Mice. Kochumon S, Malik MZ, Sindhu S, Arefanian H, Jacob T, Bahman F, Nizam R, Hasan A, Thomas R, Al-Rashed F, Shenouda S, Wilson A, Albeloushi S, Almansour N, Alhamar G, Al Madhoun A, Alzaid F, Thanaraj TA, Koistinen HA, Tuomilehto J, Al-Mulla F, Ahmad R. Nutrients. 2024 Jun 18;16(12):1929. doi: 10.3390/nu16121929.

Adipogenin Dictates Adipose Tissue Expansion by Facilitating the Assembly of a Dodecameric Seipin Complex. Li C, Sun XN, Funcke JB, Vanharanta L, Joffin N, Li Y, Prasanna X, Paredes M, Joung C, Gordillo R, Vörös C, Kulig W, Straub L, Chen S, Velasco J, Cobb A, Padula D, Wang MY, Onodera T, Varlamov O, Li Y, Liu C, Nawrocki AR, Zhao S, Oh DY, Wang ZV, Goodman JM, Wynn RM, Vattulainen I, Han Y, Ikonen E, Scherer PE. bioRxiv [Preprint]. 2024 Jul 26:2024.07.25.605195. doi: 10.1101/2024.07.25.605195.

Getting to Grips with the Oxysterol-Binding Protein Family – a Forty Year Perspective. Olkkonen VM, Ikonen E. Contact (Thousand Oaks). 2024 Aug 28;7:25152564241273598. doi: 10.1177/25152564241273598. eCollection 2024 Jan-Dec.

Sham-Controlled Randomized Pilot Trial on Baroreflex Activation Therapy in Resistant Hypertension. Simonsen JR, Vikatmaa L, Vikatmaa P, Laine M, Granroth-Wilding H, Groop PH, Tikkanen I, Gordin D. Hypertension. 2024 Aug;81(8):e91-e93. doi: 10.1161/HYPERTENSIONAHA.124.23088. Epub 2024 Jul 17.

Protein glycation products associate with progression of kidney disease and incident cardiovascular events in individuals with type 1 diabetes. Adeshara K, Gordin D, Antikainen AA, Harjutsalo V, Sandholm N, Lehto MJ, Groop PH; FinnDiane Study Group. Cardiovasc Diabetol. 2024 Jul 4;23(1):235. doi: 10.1186/s12933-024-02316-w.

Activation of the hypoxia-inducible factor pathway by roxadustat improves glucose metabolism in human primary myotubes from men. Mäkinen S, Sree S, Ala-Nisula T, Kultalahti H, Koivunen P, Koistinen HA. Diabetologia. 2024 May 30. doi: 10.1007/s00125-024-06185-6. Online ahead of print.

IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts. Li C, Li S, Zhang G, Li Q, Song W, Wang X, Cook JA, van der Stoel M, Wright BW, Altamirano F, Niewold EL, Han J, Kimble G, Zhang P, Luo X, Urra H, May HI, Ferdous A, Sun XN, Deng Y, Ikonen E, Hetz C, Kaufman RJ, Zhang K, Gillette TG, Scherer PE, Hill JA, Chen J, Wang ZV. Circulation. 2024 Jun 5. doi: 10.1161/CIRCULATIONAHA.123.067606. Online ahead of print.

Actin polymerization and longitudinal actin fibers in axon initial segment plasticity. Micinski D, Hotulainen P. Front Mol Neurosci. 2024 May 10;17:1376997. doi: 10.3389/fnmol.2024.1376997. eCollection 2024.

TWINGEN: protocol for an observational clinical biobank recall and biomarker cohort study to identify Finnish individuals with high risk of Alzheimer’s disease. Vuoksimaa E, Saari TT, Aaltonen A, Aaltonen S, Herukka SK, Iso-Markku P, Kokkola T, Kyttälä A, Kärkkäinen S, Liedes H, Ollikainen M, Palviainen T, Ruotsalainen I, Toivola A, Urjansson M, Vasankari T, Vähä-Ypyä H, Forsberg MM, Hiltunen M, Jalanko A, Kälviäinen R, Kuopio T, Lähteenmäki J, Nyberg P, Männikkö M, Serpi R, Siltanen S, Palotie A, Kaprio J, Runz H, Julkunen V; FinnGen. BMJ Open. 2024 Jun 12;14(6):e081947. doi: 10.1136/bmjopen-2023-081947.

Colonocyte keratins stabilize mitochondria and contribute to mitochondrial energy metabolism. Nyström JH, Heikkilä TRH, Thapa K, Pulli I, Törnquist K, Toivola DM. Am J Physiol Gastrointest Liver Physiol. 2024 Jun 11. doi: 10.1152/ajpgi.00220.2023. Online ahead of print.

Exploring machine learning strategies for predicting cardiovascular disease risk factors from multi-omic data. Drouard G, Mykkänen J, Heiskanen J, Pohjonen J, Ruohonen S, Pahkala K, Lehtimäki T, Wang X, Ollikainen M, Ripatti S, Pirinen M, Raitakari O, Kaprio J. BMC Med Inform Decis Mak. 2024 May 2;24(1):116. doi: 10.1186/s12911-024-02521-3.

Nature and Nurture in Familial Aggregation of Steatotic Liver Disease. Asteljoki J, Luukkonen PK. Clin Gastroenterol Hepatol. 2024 Apr 6:S1542-3565(24)00306-9. doi: 10.1016/j.cgh.2024.03.024. Online ahead of print.

Cumulative risk factors for injuries and poisoning requiring hospital care in youth with prenatal substance exposure: A longitudinal controlled cohort study. Koponen AM, Gissler M, Nissinen NM, Autti-Rämö I, Kahila H, Sarkola T. Nordisk Alkohol Nark. 2024 Apr;41(2):156-174. doi: 10.1177/14550725231202074.

Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complications. Christiansen C, Potier L, Martin TC, Villicaña S, Castillo-Fernandez JE, Mangino M, Menni C, Tsai PC, Campbell PJ, Mullin S, Ordoñana JR, Monteagudo O, Sachdev PS, Mather KA, Trollor JN, Pietilainen KH, Ollikainen M, Dalgård C, Kyvik K, Christensen K, van Dongen J, Willemsen G, Boomsma DI, Magnusson PKE, Pedersen NL, Wilson SG, Grundberg E, Spector TD, Bell JT. EBioMedicine. 2024 May;103:105096. doi: 10.1016/j.ebiom.2024.105096. Epub 2024 Apr 4.

Antidepressant Exposure and DNA Methylation: Insights from a Methylome-Wide Association Study. Davyson E, Shen X, Huider F, Adams M, Borges K, McCartney D, Barker L, Van Dongen J, Boomsma D, Weihs A, Grabe H, Kühn L, Teumer A, Völzke H, Zhu T, Kaprio J, Ollikainen M, David FS, Meinert S, Stein F, Forstner AJ, Dannlowski U, Kircher T, Tapuc A, Czamara D, Binder EB, Brückl T, Kwong A, Yousefi P, Wong C, Arseneault L, Fisher HL, Mill J, Cox S, Redmond P, Russ TC, van den Oord E, Aberg KA, Penninx B, Marioni RE, Wray NR, McIntosh AM. medRxiv [Preprint]. 2024 May 3:2024.05.01.24306640. doi: 10.1101/2024.05.01.24306640.

Evaluating the correlation of sclerostin levels with obesity and type 2 diabetes in a multiethnic population living in Kuwait. Alramah T, Cherian P, Al-Khairi I, Abu-Farha M, Thanaraj TA, Albatineh AN, Safadi F, Ali H, Abdul-Ghani M, Tuomilehto J, Koistinen HA, Al-Mulla F, Abubaker J. Front Endocrinol (Lausanne). 2024 Apr 22;15:1392675. doi: 10.3389/fendo.2024.1392675. eCollection 2024.

Ethnic Variations in the Levels of Bone Biomarkers (Osteoprostegerin, Receptor Activator of Nuclear Factor Kappa-Β Ligand and Glycoprotein Non-Metastatic Melanoma Protein B) in People with Type 2 Diabetes. Cherian P, Al-Khairi I, Abu-Farha M, Alramah T, Albatineh AN, Alhomaidah D, Safadi F, Ali H, Abdul-Ghani M, Tuomilehto J, Koistinen HA, Al-Mulla F, Abubaker J. Biomedicines. 2024 May 6;12(5):1019. doi: 10.3390/biomedicines12051019.

Combination therapy for kidney disease in people with diabetes mellitus. van Raalte DH, Bjornstad P, Cherney DZI, de Boer IH, Fioretto P, Gordin D, Persson F, Rosas SE, Rossing P, Schaub JA, Tuttle K, Waikar SS, Heerspink HJL. Nat Rev Nephrol. 2024 Apr 3. doi: 10.1038/s41581-024-00827-z. Online ahead of print.

A Clinical Study on Urinary Clusterin and Cystatin B in Dogs with Spontaneous Acute Kidney Injury. Gordin E, Viitanen S, Gordin D, Szlosek D, Peterson S, Spillmann T, Labato MA. Vet Sci. 2024 May 2;11(5):200. doi: 10.3390/vetsci11050200.

Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function. Wang H, Siren J, Perttunen S, Immonen K, Chen YC, Narumanchi S, Kosonen R, Paavola J, Laine M, Tikkanen I, Lakkisto P. J Cell Mol Med. 2024 Apr;28(7):e18243. doi: 10.1111/jcmm.18243.

Surveillance of the liver in type 2 diabetes: important but unfeasible? Qadri S, Yki-Järvinen H. Diabetologia. 2024 Feb 9. doi: 10.1007/s00125-024-06087-7. Online ahead of print.

IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids. Sasidharan K, Caddeo A, Jamialahmadi O, Noto FR, Tomasi M, Malvestiti F, Ciociola E, Tavaglione F, Mancina RM, Cherubini A, Bianco C, Mirarchi A, Männistö V, Pihlajamäki J, Kärjä V, Grimaudo S, Luukkonen PK, Qadri S, Yki-Järvinen H, Petta S, Manfrini S, Vespasiani-Gentilucci U, Bruni V, Valenti L, Romeo S. Cell Rep Med. 2024 Jan 16;5(1):101352. doi: 10.1016/j.xcrm.2023.101352.

Hepatic mitochondrial reductive stress in the pathogenesis and treatment of steatotic liver disease. Jokinen MJ, Luukkonen PK. Trends Pharmacol Sci. 2024 Mar 11:S0165-6147(24)00030-0. doi: 10.1016/j.tips.2024.02.003. Online ahead of print.

Metabolic syndrome and epigenetic aging: a twin study. Föhr T, Hendrix A, Kankaanpää A, Laakkonen EK, Kujala U, Pietiläinen KH, Lehtimäki T, Kähönen M, Raitakari O, Wang X, Kaprio J, Ollikainen M, Sillanpää E. Int J Obes (Lond). 2024 Jan 25. doi: 10.1038/s41366-024-01466-x. Online ahead of print.

Effects of fat loss and low energy availability on the serum cardiometabolic profile of physique athletes. Jouhki I, Sarin HV, Jauhiainen M, O’Connell TM, Isola V, Ahtiainen JP, Hulmi JJ, Perola M. Scand J Med Sci Sports. 2024 Jan;34(1):e14553. doi: 10.1111/sms.14553.

GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines. Nummela P, Zafar S, Veikkolainen E, Ukkola I, Cinella V, Ayo A, Asghar MY, Välimäki N, Törnquist K, Karhu A, Laakkonen P, Aaltonen LA, Ristimäki A. Int J Cancer. 2024 Feb 6. doi: 10.1002/ijc.34865. Online ahead of print.

Adipocyte-endothelial cell interplay in adipose tissue physiology. Chaurasiya V, Nidhina Haridas PA, Olkkonen VM. Biochem Pharmacol. 2024 Feb 24;222:116081. doi: 10.1016/j.bcp.2024.116081. Online ahead of print.

miR-619-5p and cardiogenic shock in patients with ST-segment elevation myocardial infarction. Escate R, Padró T, Suades R, Sans-Roselló J, Devaux Y, Lakkisto P, Harjola VP, Sionis A, Badimon L. Eur J Clin Invest. 2024 Feb 20:e14186. doi: 10.1111/eci.14186. Online ahead of print.

HiHo-AID2: boosting homozygous knock-in efficiency enables robust generation of human auxin-inducible degron cells. Li S, Wang Y, van der Stoel M, Zhou X, Madhusudan S, Kanerva K, Nguyen VD, Eskici N, Olkkonen VM, Zhou Y, Raivio T, Ikonen E. Genome Biol. 2024 Feb 26;25(1):58. doi: 10.1186/s13059-024-03187-w.

Sex-specific genetic risks for adverse outcomes after coronary revascularization procedures. Nurkkala JM, Aittokallio J; FinnGen; Kauko A, Niiranen T. Interdiscip Cardiovasc Thorac Surg. 2024 Jan 2;38(1):ivae006. doi: 10.1093/icvts/ivae006.

High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases. Youssef O, Loukola A, Zidi-Mouaffak YHS, Tamlander M, Ruotsalainen S, Kilpeläinen E, Mars N, Ripatti S; FinnGen; Palotie A, Donner K, Carpén O. Lab Invest. 2024 Jan 14;104(4):100325. doi: 10.1016/j.labinv.2024.100325. Online ahead of print.

Retinal artery to vein ratio is associated with cerebral microbleeds in individuals with type 1 diabetes. Tarkkonen A, Fickweiler W, Eriksson M, Sun JK, Thorn LM, Summanen P, Groop PH, Putaala J, Martola J, Gordin D; FinnDiane Study Group. J Hypertens. 2024 Feb 28. doi: 10.1097/HJH.0000000000003690. Online ahead of print.

Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women. Mars N, Kerminen S, Tamlander M, Pirinen M, Jakkula E, Aaltonen K, Meretoja T, Heinävaara S, Widén E, Ripatti S; FinnGen. J Clin Oncol. 2024 Feb 29:JCO2300295. doi: 10.1200/JCO.23.00295. Online ahead of print.

The first human normative ranges and biomarker performance of dimethylguanidino valeric acid isoforms in fatty liver disease. Qadri S, Wang X, Tran C, Fitzpatrick M, Bonnitcha P, Sullivan D, Yki-Järvinen H, O’Sullivan JF. Pathology. 2023 Nov 23:S0031-3025(23)00296-9. doi: 10.1016/j.pathol.2023.10.006. Online ahead of print.

Marked difference in liver fat measured by histology vs. magnetic resonance-proton density fat fraction: A meta-analysis. Qadri S, Vartiainen E, Lahelma M, Porthan K, Tang A, Idilman IS, Runge JH, Juuti A, Penttilä AK, Dabek J, Lehtimäki TE, Seppänen W, Arola J, Arkkila P, Stoker J, Karcaaltincaba M, Pavlides M, Loomba R, Sirlin CB, Tukiainen T, Yki-Järvinen H. JHEP Rep. 2023 Oct 11;6(1):100928. doi: 10.1016/j.jhepr.2023.100928. eCollection 2024 Jan.

Combined use of the CLivD score and FIB-4 for prediction of liver-related outcomes in the population. Åberg F, Asteljoki J, Männistö V, Luukkonen PK. Hepatology. 2023 Dec 19. doi: 10.1097/HEP.0000000000000707. Online ahead of print.

Associations Between Sedentary Time, Physical Activity, and Cardiovascular Health in 6-Year-Old Children Born to Mothers With Increased Cardiometabolic Risk. Litwin L, Sundholm JKM, Olander RFW, Meinilä J, Kulmala J, Tammelin TH, Rönö K, Koivusalo SB, Eriksson JG, Sarkola T. Pediatr Exerc Sci. 2023 Dec 28:1-9. doi: 10.1123/pes.2023-0058. Online ahead of print.

No correlation between carotid intima-media thickness and long-term glycemic control in individuals with type 1 diabetes. Inkeri J, Harjutsalo V, Martola J, Putaala J, Groop PH, Gordin D, Thorn LM; FinnDiane Study Group. Acta Diabetol. 2023 Dec 10. doi: 10.1007/s00592-023-02211-y. Online ahead of print.

Oxy- and Phytosterols as Biomarkers: Current Status and Future Perspectives. Olkkonen VM, Gylling H.Adv Exp Med Biol. 2024;1440:353-375. doi: 10.1007/978-3-031-43883-7_18.

Preeclampsia-exposed children’s heart rate variability 8-12 yr after index pregnancy: FINNCARE study. Renlund M, Tulppo MP, Kivelä A, Laivuori H, Heinonen S, Jääskeläinen T, Sarkola T.Am J Physiol Heart Circ Physiol. 2024 Jan 1;326(1):H74-H81. doi: 10.1152/ajpheart.00540.2023. Epub 2023 Nov 3.

The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans. Luukkonen PK, Porthan K, Ahlholm N, Rosqvist F, Dufour S, Zhang XM, Lehtimäki TE, Seppänen W, Orho-Melander M, Hodson L, Petersen KF, Shulman GI, Yki-Järvinen H.Cell Metab. 2023 Nov 7;35(11):1887-1896.e5. doi: 10.1016/j.cmet.2023.10.008. Epub 2023 Oct 30.

Determinants of vascular structure and function in at-risk children born to mothers managed for pre-eclampsia (FINNCARE study). Renlund M, Jääskeläinen T, Kivelä A, Heinonen S, Laivuori H, Sarkola T.Front Cardiovasc Med. 2023 Oct 4;10:1264921. doi: 10.3389/fcvm.2023.1264921. eCollection 2023.

Trans-ancestry epigenome-wide association meta-analysis of DNA methylation with lifetime cannabis use. Fang F, Quach B, Lawrence KG, van Dongen J, Marks JA, Lundgren S, Lin M, Odintsova VV, Costeira R, Xu Z, Zhou L, Mandal M, Xia Y, Vink JM, Bierut LJ, Ollikainen M, Taylor JA, Bell JT, Kaprio J, Boomsma DI, Xu K, Sandler DP, Hancock DB, Johnson EO.Mol Psychiatry. 2023 Nov 7. doi: 10.1038/s41380-023-02310-w. Online ahead of print.

DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study. Sehovic E, Zellers SM, Youssef MK, Heikkinen A, Kaprio J, Ollikainen M.Clin Epigenetics. 2023 Nov 10;15(1):181. doi: 10.1186/s13148-023-01594-7.

Human HDL subclasses modulate energy metabolism in skeletal muscle cells. Lund J, Lähteenmäki E, Eklund T, Bakke HG, Thoresen GH, Pirinen E, Jauhiainen M, Rustan AC, Lehti M.J Lipid Res. 2023 Nov 24:100481. doi: 10.1016/j.jlr.2023.100481. Online ahead of print.

SGMS2 in primary osteoporosis with facial nerve palsy. Pihlström S, Richardt S, Määttä K, Pekkinen M, Olkkonen VM, Mäkitie O, Mäkitie RE.Front Endocrinol (Lausanne). 2023 Oct 11;14:1224318. doi: 10.3389/fendo.2023.1224318. eCollection 2023.

Human visceral adipose tissue microvascular endothelial cell isolation and establishment of co-culture with white adipocytes to analyze cell-cell communication. Chaurasiya V, Pham DD, Harju J, Juuti A, Penttilä A, Emmagouni SKG, Nguyen VD, Zhang B, Perttunen S, Keskitalo S, Zhou Y, Pietiläinen KH, Haridas PAN, Olkkonen VM.Exp Cell Res. 2023 Oct 16:113819. doi: 10.1016/j.yexcr.2023.113819. Online ahead of print.

Multivariate analyses of immune markers reveal increases in plasma EN-RAGE in first-episode psychosis patients. Korhonen L, Paul ER, Wåhlén K, Haring L, Vasar E, Vaheri A, Lindholm D.Transl Psychiatry. 2023 Oct 20;13(1):326. doi: 10.1038/s41398-023-02627-8.

Adipose tissue eQTL meta-analysis reveals the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits. Brotman SM, El-Sayed Moustafa JS, Guan L, Broadaway KA, Wang D, Jackson AU, Welch R, Currin KW, Tomlinson M, Vadlamudi S, Stringham HM, Roberts AL, Lakka TA, Oravilahti A, Silva LF, Narisu N, Erdos MR, Yan T, Bonnycastle LL, Raulerson CK, Raza Y, Yan X, Parker SCJ, Kuusisto J, Pajukanta P, Tuomilehto J, Collins FS, Boehnke M, Love MI, Koistinen HA, Laakso M, Mohlke KL, Small KS, Scott LJ.bioRxiv. 2023 Oct 27:2023.10.26.563798. doi: 10.1101/2023.10.26.563798. Preprint.

NTHL1 is a recessive cancer susceptibility gene. Nurmi AK, Pelttari LM, Kiiski JI, Khan S, Nurmikolu M, Suvanto M, Aho N, Tasmuth T, Kalso E, Schleutker J, Kallioniemi A, Heikkilä P; FinnGen; Aittomäki K, Blomqvist C, Nevanlinna H.Sci Rep. 2023 Nov 30;13(1):21127. doi: 10.1038/s41598-023-47441-w.

Proliferation and migration of ML1 follicular thyroid cancer cells are inhibited by IU1 targeting USP14: role of proteasome and autophagy flux. Srinivasan V, Asghar MY, Zafar S, Törnquist K, Lindholm D. Front Cell Dev Biol. 2023 Aug 30;11:1234204. doi: 10.3389/fcell.2023.1234204. eCollection 2023.

Linkage analysis using whole exome sequencing data implicates SLC17A1, SLC17A3, TATDN2 and TMEM131L in type 1 diabetes in Kuwaiti families. Hebbar P, Nizam R, John SE, Antony D, Dashti M, Channanath A, Shaltout A, Al-Khandari H, Koistinen HA, Tuomilehto J, Alsmadi O, Thanaraj TA, Al-Mulla F. Sci Rep. 2023 Sep 11;13(1):14978. doi: 10.1038/s41598-023-42255-2.

Protective Factors and the Pathogenesis of Complications in Diabetes. Yu MG, Gordin D, Fu J, Park K, Li Q, King GL. Endocr Rev. 2023 Aug 28:bnad030. doi: 10.1210/endrev/bnad030. Online ahead of print.

A FinnGen pilot clinical recall study for Alzheimer’s disease. Julkunen V, Schwarz C, Kalapudas J, Hallikainen M, Piironen AK, Mannermaa A, Kujala H, Laitinen T, Kosma VM, Paajanen TI, Kälviäinen R, Hiltunen M, Herukka SK, Kärkkäinen S, Kokkola T, Urjansson M; FinnGen; Perola M, Palotie A, Vuoksimaa E, Runz H. Sci Rep. 2023 Aug 3;13(1):12641. doi: 10.1038/s41598-023-39835-7.