Latest publications

Activation of the hypoxia-inducible factor pathway by roxadustat improves glucose metabolism in human primary myotubes from men. Mäkinen S, Sree S, Ala-Nisula T, Kultalahti H, Koivunen P, Koistinen HA. Diabetologia. 2024 May 30. doi: 10.1007/s00125-024-06185-6. Online ahead of print.

IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts. Li C, Li S, Zhang G, Li Q, Song W, Wang X, Cook JA, van der Stoel M, Wright BW, Altamirano F, Niewold EL, Han J, Kimble G, Zhang P, Luo X, Urra H, May HI, Ferdous A, Sun XN, Deng Y, Ikonen E, Hetz C, Kaufman RJ, Zhang K, Gillette TG, Scherer PE, Hill JA, Chen J, Wang ZV. Circulation. 2024 Jun 5. doi: 10.1161/CIRCULATIONAHA.123.067606. Online ahead of print.

Actin polymerization and longitudinal actin fibers in axon initial segment plasticity. Micinski D, Hotulainen P. Front Mol Neurosci. 2024 May 10;17:1376997. doi: 10.3389/fnmol.2024.1376997. eCollection 2024.

TWINGEN: protocol for an observational clinical biobank recall and biomarker cohort study to identify Finnish individuals with high risk of Alzheimer’s disease. Vuoksimaa E, Saari TT, Aaltonen A, Aaltonen S, Herukka SK, Iso-Markku P, Kokkola T, Kyttälä A, Kärkkäinen S, Liedes H, Ollikainen M, Palviainen T, Ruotsalainen I, Toivola A, Urjansson M, Vasankari T, Vähä-Ypyä H, Forsberg MM, Hiltunen M, Jalanko A, Kälviäinen R, Kuopio T, Lähteenmäki J, Nyberg P, Männikkö M, Serpi R, Siltanen S, Palotie A, Kaprio J, Runz H, Julkunen V; FinnGen. BMJ Open. 2024 Jun 12;14(6):e081947. doi: 10.1136/bmjopen-2023-081947.

Colonocyte keratins stabilize mitochondria and contribute to mitochondrial energy metabolism. Nyström JH, Heikkilä TRH, Thapa K, Pulli I, Törnquist K, Toivola DM. Am J Physiol Gastrointest Liver Physiol. 2024 Jun 11. doi: 10.1152/ajpgi.00220.2023. Online ahead of print.

Exploring machine learning strategies for predicting cardiovascular disease risk factors from multi-omic data. Drouard G, Mykkänen J, Heiskanen J, Pohjonen J, Ruohonen S, Pahkala K, Lehtimäki T, Wang X, Ollikainen M, Ripatti S, Pirinen M, Raitakari O, Kaprio J. BMC Med Inform Decis Mak. 2024 May 2;24(1):116. doi: 10.1186/s12911-024-02521-3.

Nature and Nurture in Familial Aggregation of Steatotic Liver Disease. Asteljoki J, Luukkonen PK. Clin Gastroenterol Hepatol. 2024 Apr 6:S1542-3565(24)00306-9. doi: 10.1016/j.cgh.2024.03.024. Online ahead of print.

Cumulative risk factors for injuries and poisoning requiring hospital care in youth with prenatal substance exposure: A longitudinal controlled cohort study. Koponen AM, Gissler M, Nissinen NM, Autti-Rämö I, Kahila H, Sarkola T. Nordisk Alkohol Nark. 2024 Apr;41(2):156-174. doi: 10.1177/14550725231202074.

Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complications. Christiansen C, Potier L, Martin TC, Villicaña S, Castillo-Fernandez JE, Mangino M, Menni C, Tsai PC, Campbell PJ, Mullin S, Ordoñana JR, Monteagudo O, Sachdev PS, Mather KA, Trollor JN, Pietilainen KH, Ollikainen M, Dalgård C, Kyvik K, Christensen K, van Dongen J, Willemsen G, Boomsma DI, Magnusson PKE, Pedersen NL, Wilson SG, Grundberg E, Spector TD, Bell JT. EBioMedicine. 2024 May;103:105096. doi: 10.1016/j.ebiom.2024.105096. Epub 2024 Apr 4.

Antidepressant Exposure and DNA Methylation: Insights from a Methylome-Wide Association Study. Davyson E, Shen X, Huider F, Adams M, Borges K, McCartney D, Barker L, Van Dongen J, Boomsma D, Weihs A, Grabe H, Kühn L, Teumer A, Völzke H, Zhu T, Kaprio J, Ollikainen M, David FS, Meinert S, Stein F, Forstner AJ, Dannlowski U, Kircher T, Tapuc A, Czamara D, Binder EB, Brückl T, Kwong A, Yousefi P, Wong C, Arseneault L, Fisher HL, Mill J, Cox S, Redmond P, Russ TC, van den Oord E, Aberg KA, Penninx B, Marioni RE, Wray NR, McIntosh AM. medRxiv [Preprint]. 2024 May 3:2024.05.01.24306640. doi: 10.1101/2024.05.01.24306640.

Evaluating the correlation of sclerostin levels with obesity and type 2 diabetes in a multiethnic population living in Kuwait. Alramah T, Cherian P, Al-Khairi I, Abu-Farha M, Thanaraj TA, Albatineh AN, Safadi F, Ali H, Abdul-Ghani M, Tuomilehto J, Koistinen HA, Al-Mulla F, Abubaker J. Front Endocrinol (Lausanne). 2024 Apr 22;15:1392675. doi: 10.3389/fendo.2024.1392675. eCollection 2024.

Ethnic Variations in the Levels of Bone Biomarkers (Osteoprostegerin, Receptor Activator of Nuclear Factor Kappa-Β Ligand and Glycoprotein Non-Metastatic Melanoma Protein B) in People with Type 2 Diabetes. Cherian P, Al-Khairi I, Abu-Farha M, Alramah T, Albatineh AN, Alhomaidah D, Safadi F, Ali H, Abdul-Ghani M, Tuomilehto J, Koistinen HA, Al-Mulla F, Abubaker J. Biomedicines. 2024 May 6;12(5):1019. doi: 10.3390/biomedicines12051019.

Combination therapy for kidney disease in people with diabetes mellitus. van Raalte DH, Bjornstad P, Cherney DZI, de Boer IH, Fioretto P, Gordin D, Persson F, Rosas SE, Rossing P, Schaub JA, Tuttle K, Waikar SS, Heerspink HJL. Nat Rev Nephrol. 2024 Apr 3. doi: 10.1038/s41581-024-00827-z. Online ahead of print.

A Clinical Study on Urinary Clusterin and Cystatin B in Dogs with Spontaneous Acute Kidney Injury. Gordin E, Viitanen S, Gordin D, Szlosek D, Peterson S, Spillmann T, Labato MA. Vet Sci. 2024 May 2;11(5):200. doi: 10.3390/vetsci11050200.

Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function. Wang H, Siren J, Perttunen S, Immonen K, Chen YC, Narumanchi S, Kosonen R, Paavola J, Laine M, Tikkanen I, Lakkisto P. J Cell Mol Med. 2024 Apr;28(7):e18243. doi: 10.1111/jcmm.18243.

Surveillance of the liver in type 2 diabetes: important but unfeasible? Qadri S, Yki-Järvinen H. Diabetologia. 2024 Feb 9. doi: 10.1007/s00125-024-06087-7. Online ahead of print.

IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids. Sasidharan K, Caddeo A, Jamialahmadi O, Noto FR, Tomasi M, Malvestiti F, Ciociola E, Tavaglione F, Mancina RM, Cherubini A, Bianco C, Mirarchi A, Männistö V, Pihlajamäki J, Kärjä V, Grimaudo S, Luukkonen PK, Qadri S, Yki-Järvinen H, Petta S, Manfrini S, Vespasiani-Gentilucci U, Bruni V, Valenti L, Romeo S. Cell Rep Med. 2024 Jan 16;5(1):101352. doi: 10.1016/j.xcrm.2023.101352.

Hepatic mitochondrial reductive stress in the pathogenesis and treatment of steatotic liver disease. Jokinen MJ, Luukkonen PK. Trends Pharmacol Sci. 2024 Mar 11:S0165-6147(24)00030-0. doi: 10.1016/j.tips.2024.02.003. Online ahead of print.

Metabolic syndrome and epigenetic aging: a twin study. Föhr T, Hendrix A, Kankaanpää A, Laakkonen EK, Kujala U, Pietiläinen KH, Lehtimäki T, Kähönen M, Raitakari O, Wang X, Kaprio J, Ollikainen M, Sillanpää E. Int J Obes (Lond). 2024 Jan 25. doi: 10.1038/s41366-024-01466-x. Online ahead of print.

Effects of fat loss and low energy availability on the serum cardiometabolic profile of physique athletes. Jouhki I, Sarin HV, Jauhiainen M, O’Connell TM, Isola V, Ahtiainen JP, Hulmi JJ, Perola M. Scand J Med Sci Sports. 2024 Jan;34(1):e14553. doi: 10.1111/sms.14553.

GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines. Nummela P, Zafar S, Veikkolainen E, Ukkola I, Cinella V, Ayo A, Asghar MY, Välimäki N, Törnquist K, Karhu A, Laakkonen P, Aaltonen LA, Ristimäki A. Int J Cancer. 2024 Feb 6. doi: 10.1002/ijc.34865. Online ahead of print.

Adipocyte-endothelial cell interplay in adipose tissue physiology. Chaurasiya V, Nidhina Haridas PA, Olkkonen VM. Biochem Pharmacol. 2024 Feb 24;222:116081. doi: 10.1016/j.bcp.2024.116081. Online ahead of print.

miR-619-5p and cardiogenic shock in patients with ST-segment elevation myocardial infarction. Escate R, Padró T, Suades R, Sans-Roselló J, Devaux Y, Lakkisto P, Harjola VP, Sionis A, Badimon L. Eur J Clin Invest. 2024 Feb 20:e14186. doi: 10.1111/eci.14186. Online ahead of print.

HiHo-AID2: boosting homozygous knock-in efficiency enables robust generation of human auxin-inducible degron cells. Li S, Wang Y, van der Stoel M, Zhou X, Madhusudan S, Kanerva K, Nguyen VD, Eskici N, Olkkonen VM, Zhou Y, Raivio T, Ikonen E. Genome Biol. 2024 Feb 26;25(1):58. doi: 10.1186/s13059-024-03187-w.

Sex-specific genetic risks for adverse outcomes after coronary revascularization procedures. Nurkkala JM, Aittokallio J; FinnGen; Kauko A, Niiranen T. Interdiscip Cardiovasc Thorac Surg. 2024 Jan 2;38(1):ivae006. doi: 10.1093/icvts/ivae006.

High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases. Youssef O, Loukola A, Zidi-Mouaffak YHS, Tamlander M, Ruotsalainen S, Kilpeläinen E, Mars N, Ripatti S; FinnGen; Palotie A, Donner K, Carpén O. Lab Invest. 2024 Jan 14;104(4):100325. doi: 10.1016/j.labinv.2024.100325. Online ahead of print.

Retinal artery to vein ratio is associated with cerebral microbleeds in individuals with type 1 diabetes. Tarkkonen A, Fickweiler W, Eriksson M, Sun JK, Thorn LM, Summanen P, Groop PH, Putaala J, Martola J, Gordin D; FinnDiane Study Group. J Hypertens. 2024 Feb 28. doi: 10.1097/HJH.0000000000003690. Online ahead of print.

Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women. Mars N, Kerminen S, Tamlander M, Pirinen M, Jakkula E, Aaltonen K, Meretoja T, Heinävaara S, Widén E, Ripatti S; FinnGen. J Clin Oncol. 2024 Feb 29:JCO2300295. doi: 10.1200/JCO.23.00295. Online ahead of print.

The first human normative ranges and biomarker performance of dimethylguanidino valeric acid isoforms in fatty liver disease. Qadri S, Wang X, Tran C, Fitzpatrick M, Bonnitcha P, Sullivan D, Yki-Järvinen H, O’Sullivan JF. Pathology. 2023 Nov 23:S0031-3025(23)00296-9. doi: 10.1016/j.pathol.2023.10.006. Online ahead of print.

Marked difference in liver fat measured by histology vs. magnetic resonance-proton density fat fraction: A meta-analysis. Qadri S, Vartiainen E, Lahelma M, Porthan K, Tang A, Idilman IS, Runge JH, Juuti A, Penttilä AK, Dabek J, Lehtimäki TE, Seppänen W, Arola J, Arkkila P, Stoker J, Karcaaltincaba M, Pavlides M, Loomba R, Sirlin CB, Tukiainen T, Yki-Järvinen H. JHEP Rep. 2023 Oct 11;6(1):100928. doi: 10.1016/j.jhepr.2023.100928. eCollection 2024 Jan.

Combined use of the CLivD score and FIB-4 for prediction of liver-related outcomes in the population. Åberg F, Asteljoki J, Männistö V, Luukkonen PK. Hepatology. 2023 Dec 19. doi: 10.1097/HEP.0000000000000707. Online ahead of print.

Associations Between Sedentary Time, Physical Activity, and Cardiovascular Health in 6-Year-Old Children Born to Mothers With Increased Cardiometabolic Risk. Litwin L, Sundholm JKM, Olander RFW, Meinilä J, Kulmala J, Tammelin TH, Rönö K, Koivusalo SB, Eriksson JG, Sarkola T. Pediatr Exerc Sci. 2023 Dec 28:1-9. doi: 10.1123/pes.2023-0058. Online ahead of print.

No correlation between carotid intima-media thickness and long-term glycemic control in individuals with type 1 diabetes. Inkeri J, Harjutsalo V, Martola J, Putaala J, Groop PH, Gordin D, Thorn LM; FinnDiane Study Group. Acta Diabetol. 2023 Dec 10. doi: 10.1007/s00592-023-02211-y. Online ahead of print.

Oxy- and Phytosterols as Biomarkers: Current Status and Future Perspectives. Olkkonen VM, Gylling H.Adv Exp Med Biol. 2024;1440:353-375. doi: 10.1007/978-3-031-43883-7_18.

Preeclampsia-exposed children’s heart rate variability 8-12 yr after index pregnancy: FINNCARE study. Renlund M, Tulppo MP, Kivelä A, Laivuori H, Heinonen S, Jääskeläinen T, Sarkola T.Am J Physiol Heart Circ Physiol. 2024 Jan 1;326(1):H74-H81. doi: 10.1152/ajpheart.00540.2023. Epub 2023 Nov 3.

The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans. Luukkonen PK, Porthan K, Ahlholm N, Rosqvist F, Dufour S, Zhang XM, Lehtimäki TE, Seppänen W, Orho-Melander M, Hodson L, Petersen KF, Shulman GI, Yki-Järvinen H.Cell Metab. 2023 Nov 7;35(11):1887-1896.e5. doi: 10.1016/j.cmet.2023.10.008. Epub 2023 Oct 30.

Determinants of vascular structure and function in at-risk children born to mothers managed for pre-eclampsia (FINNCARE study). Renlund M, Jääskeläinen T, Kivelä A, Heinonen S, Laivuori H, Sarkola T.Front Cardiovasc Med. 2023 Oct 4;10:1264921. doi: 10.3389/fcvm.2023.1264921. eCollection 2023.

Trans-ancestry epigenome-wide association meta-analysis of DNA methylation with lifetime cannabis use. Fang F, Quach B, Lawrence KG, van Dongen J, Marks JA, Lundgren S, Lin M, Odintsova VV, Costeira R, Xu Z, Zhou L, Mandal M, Xia Y, Vink JM, Bierut LJ, Ollikainen M, Taylor JA, Bell JT, Kaprio J, Boomsma DI, Xu K, Sandler DP, Hancock DB, Johnson EO.Mol Psychiatry. 2023 Nov 7. doi: 10.1038/s41380-023-02310-w. Online ahead of print.

DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study. Sehovic E, Zellers SM, Youssef MK, Heikkinen A, Kaprio J, Ollikainen M.Clin Epigenetics. 2023 Nov 10;15(1):181. doi: 10.1186/s13148-023-01594-7.

Human HDL subclasses modulate energy metabolism in skeletal muscle cells. Lund J, Lähteenmäki E, Eklund T, Bakke HG, Thoresen GH, Pirinen E, Jauhiainen M, Rustan AC, Lehti M.J Lipid Res. 2023 Nov 24:100481. doi: 10.1016/j.jlr.2023.100481. Online ahead of print.

SGMS2 in primary osteoporosis with facial nerve palsy. Pihlström S, Richardt S, Määttä K, Pekkinen M, Olkkonen VM, Mäkitie O, Mäkitie RE.Front Endocrinol (Lausanne). 2023 Oct 11;14:1224318. doi: 10.3389/fendo.2023.1224318. eCollection 2023.

Human visceral adipose tissue microvascular endothelial cell isolation and establishment of co-culture with white adipocytes to analyze cell-cell communication. Chaurasiya V, Pham DD, Harju J, Juuti A, Penttilä A, Emmagouni SKG, Nguyen VD, Zhang B, Perttunen S, Keskitalo S, Zhou Y, Pietiläinen KH, Haridas PAN, Olkkonen VM.Exp Cell Res. 2023 Oct 16:113819. doi: 10.1016/j.yexcr.2023.113819. Online ahead of print.

Multivariate analyses of immune markers reveal increases in plasma EN-RAGE in first-episode psychosis patients. Korhonen L, Paul ER, Wåhlén K, Haring L, Vasar E, Vaheri A, Lindholm D.Transl Psychiatry. 2023 Oct 20;13(1):326. doi: 10.1038/s41398-023-02627-8.

Adipose tissue eQTL meta-analysis reveals the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits. Brotman SM, El-Sayed Moustafa JS, Guan L, Broadaway KA, Wang D, Jackson AU, Welch R, Currin KW, Tomlinson M, Vadlamudi S, Stringham HM, Roberts AL, Lakka TA, Oravilahti A, Silva LF, Narisu N, Erdos MR, Yan T, Bonnycastle LL, Raulerson CK, Raza Y, Yan X, Parker SCJ, Kuusisto J, Pajukanta P, Tuomilehto J, Collins FS, Boehnke M, Love MI, Koistinen HA, Laakso M, Mohlke KL, Small KS, Scott LJ.bioRxiv. 2023 Oct 27:2023.10.26.563798. doi: 10.1101/2023.10.26.563798. Preprint.

NTHL1 is a recessive cancer susceptibility gene. Nurmi AK, Pelttari LM, Kiiski JI, Khan S, Nurmikolu M, Suvanto M, Aho N, Tasmuth T, Kalso E, Schleutker J, Kallioniemi A, Heikkilä P; FinnGen; Aittomäki K, Blomqvist C, Nevanlinna H.Sci Rep. 2023 Nov 30;13(1):21127. doi: 10.1038/s41598-023-47441-w.

The associations of long-term physical activity in adulthood with later biological ageing and all-cause mortality – a prospective twin study. Kankaanpää A, Tolvanen A, Joensuu L, Waller K, Heikkinen A, Kaprio J, Ollikainen M, Sillanpää E. medRxiv. 2023 Jun 5:2023.06.02.23290916. doi: 10.1101/2023.06.02.23290916. Preprint.

Development and Validation of the Nonalcoholic Fatty Liver Disease Familial Risk Score to Detect Advanced Fibrosis: A Prospective, Multicenter Study. Huang DQ, Ahlholm N, Luukkonen PK, Porthan K, Amangurbanova M, Madamba E, Bettencourt R, Siddiqi H, Cervantes V, Hernandez C, Lopez SJ, Richards L, Nemes K, Isoniemi H, Yki-Järvinen H, Loomba R. Clin Gastroenterol Hepatol. 2023 Jul 3:S1542-3565(23)00505-0. doi: 10.1016/j.cgh.2023.06.020. Online ahead of print.

Early counselling to improve oral health behavior in children with major congenital heart defects – a randomized controlled trial. Karikoski E, Sarkola T, Blomqvist M. Caries Res. 2023 Jul 13. doi: 10.1159/000531817. Online ahead of print.

Proliferation and migration of ML1 follicular thyroid cancer cells are inhibited by IU1 targeting USP14: role of proteasome and autophagy flux. Srinivasan V, Asghar MY, Zafar S, Törnquist K, Lindholm D. Front Cell Dev Biol. 2023 Aug 30;11:1234204. doi: 10.3389/fcell.2023.1234204. eCollection 2023.

Linkage analysis using whole exome sequencing data implicates SLC17A1, SLC17A3, TATDN2 and TMEM131L in type 1 diabetes in Kuwaiti families. Hebbar P, Nizam R, John SE, Antony D, Dashti M, Channanath A, Shaltout A, Al-Khandari H, Koistinen HA, Tuomilehto J, Alsmadi O, Thanaraj TA, Al-Mulla F. Sci Rep. 2023 Sep 11;13(1):14978. doi: 10.1038/s41598-023-42255-2.

ATPase activity of DFCP1 controls selective autophagy. Nähse V, Raiborg C, Tan KW, Mørk S, Torgersen ML, Wenzel EM, Nager M, Salo VT, Johansen T, Ikonen E, Schink KO, Stenmark H. Nat Commun. 2023 Jul 8;14(1):4051. doi: 10.1038/s41467-023-39641-9.

Protective Factors and the Pathogenesis of Complications in Diabetes. Yu MG, Gordin D, Fu J, Park K, Li Q, King GL. Endocr Rev. 2023 Aug 28:bnad030. doi: 10.1210/endrev/bnad030. Online ahead of print.

A FinnGen pilot clinical recall study for Alzheimer’s disease. Julkunen V, Schwarz C, Kalapudas J, Hallikainen M, Piironen AK, Mannermaa A, Kujala H, Laitinen T, Kosma VM, Paajanen TI, Kälviäinen R, Hiltunen M, Herukka SK, Kärkkäinen S, Kokkola T, Urjansson M; FinnGen; Perola M, Palotie A, Vuoksimaa E, Runz H. Sci Rep. 2023 Aug 3;13(1):12641. doi: 10.1038/s41598-023-39835-7.

Genetic Risk Factors Associated with Preeclampsia and Hypertensive Disorders of Pregnancy. Tyrmi JS, Kaartokallio T, Lokki AI, Jääskeläinen T, Kortelainen E, Ruotsalainen S, Karjalainen J, Ripatti S, Kivioja A, Laisk T, Kettunen J, Pouta A, Kivinen K, Kajantie E, Heinonen S, Kere J, Laivuori H; FINNPEC Study Group, FinnGen Project, and the Estonian Biobank Research Team. JAMA Cardiol. 2023 Jun 7:e231312. doi: 10.1001/jamacardio.2023.1312. Online ahead of print.

The public health impact of poor sleep on severe COVID-19, influenza and upper respiratory infections. Jones SE, Maisha FI, Strausz SJ, Lammi V, Cade BE, Tervi A, Helaakoski V, Broberg ME; FinnGen; Lane JM, Redline S, Saxena R, Ollila HM. EBioMedicine. 2023 Jun 5:104630. doi: 10.1016/j.ebiom.2023.104630. Online ahead of print.

Major Genetic Risk Factors for Dupuytren’s Disease Are Inherited From Neandertals. Ågren R, Patil S, Zhou X; FinnGen.; Sahlholm K, Pääbo S, Zeberg H. Mol Biol Evol. 2023 Jun 1;40(6):msad130. doi: 10.1093/molbev/msad130.

Data Resource Profile: Nationwide registry data for high-throughput epidemiology and machine learning (FinRegistry). Viippola E, Kuitunen S, Rodosthenous RS, Vabalas A, Hartonen T, Vartiainen P, Demmler J, Vuorinen AL, Liu A, Havulinna AS, Llorens V, Detrois KE, Wang F, Ferro M, Karvanen A, German J, Jukarainen S, Gracia-Tabuenca J, Hiekkalinna T, Koskelainen S, Kiiskinen T, Lahtela E, Lemmelä S, Paajanen T, Siirtola H, Reeve MP, Kristiansson K, Brunfeldt M, Aavikko M, Gen F, Perola M, Ganna A; FinnGen. Int J Epidemiol. 2023 Jun 26:dyad091. doi: 10.1093/ije/dyad091. Online ahead of print.

Atrophy of the optic chiasm is associated with microvascular diabetic complications in type 1 diabetes. Tarkkonen A, Claesson TB, Eriksson MI, Forsblom C, Thorn LM, Summanen P, Groop PH, Putaala J, Gordin D, Martola J. Front Endocrinol (Lausanne). 2023 May 30;14:1134530. doi: 10.3389/fendo.2023.1134530. eCollection 2023.

Blood pressure, arterial stiffness, and cardiovascular risk profiles in 8-12-year-old children following preeclampsia (FINNCARE-study). Renlund MA, Jääskeläinen TJ, Kivelä ASE, Heinonen ST, Laivuori HM, Sarkola TA. J Hypertens. 2023 Jun 20. doi: 10.1097/HJH.0000000000003485. Online ahead of print.

Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle. Voisin S, Seale K, Jacques M, Landen S, Harvey NR, Haupt LM, Griffiths LR, Ashton KJ, Coffey VG, Thompson JM, Doering TM, Lindholm ME, Walsh C, Davison G, Irwin R, McBride C, Hansson O, Asplund O, Heikkinen AE, Piirilä P, Pietiläinen KH, Ollikainen M, Blocquiaux S, Thomis M, Dawn CK, Sharples AP, Eynon N. Aging Cell. 2023 May 2:e13859. doi: 10.1111/acel.13859. Online ahead of print.

Systemwide effects of ER-intracellular membrane contact site disturbance in primary endothelial cells. Taskinen JH, Ruhanen H, Matysik S, Käkelä R, Olkkonen VM. J Steroid Biochem Mol Biol. 2023 Jun 13;232:106349. doi: 10.1016/j.jsbmb.2023.106349. Online ahead of print.

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake. Williamson A, Norris DM, Yin X, Broadaway KA, Moxley AH, Vadlamudi S, Wilson EP, Jackson AU, Ahuja V, Andersen MK, Arzumanyan Z, Bonnycastle LL, Bornstein SR, Bretschneider MP, Buchanan TA, Chang YC, Chuang LM, Chung RH, Clausen TD, Damm P, Delgado GE, de Mello VD, Dupuis J, Dwivedi OP, Erdos MR, Silva LF, Frayling TM, Gieger C, Goodarzi MO, Guo X, Gustafsson S, Hakaste L, Hammar U, Hatem G, Herrmann S, Højlund K, Horn K, Hsueh WA, Hung YJ, Hwu CM, Jonsson A, Kårhus LL, Kleber ME, Kovacs P, Lakka TA, Lauzon M, Lee IT, Lindgren CM, Lindström J, Linneberg A, Liu CT, Luan J, Aly DM, Mathiesen E, Moissl AP, Morris AP, Narisu N, Perakakis N, Peters A, Prasad RB, Rodionov RN, Roll K, Rundsten CF, Sarnowski C, Savonen K, Scholz M, Sharma S, Stinson SE, Suleman S, Tan J, Taylor KD, Uusitupa M, Vistisen D, Witte DR, Walther R, Wu P, Xiang AH, Zethelius B; Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC); Ahlqvist E, Bergman RN, Chen YI, Collins FS, Fall T, Florez JC, Fritsche A, Grallert H, Groop L, Hansen T, Koistinen HA, Komulainen P, Laakso M, Lind L, Loeffler M, März W, Meigs JB, Raffel LJ, Rauramaa R, Rotter JI, Schwarz PEH, Stumvoll M, Sundström J, Tönjes… Nat Genet. 2023 Jun;55(6):973-983. doi: 10.1038/s41588-023-01408-9. Epub 2023 Jun 8.

Intracellular Cholesterol Trafficking. Ikonen E, Olkkonen VM. Cold Spring Harb Perspect Biol. 2023 Jun 5:a041404. doi: 10.1101/cshperspect.a041404. Online ahead of print.