Latest publications

Metabolic dysfunction-associated steatotic liver disease in adults. Huang DQ, Wong VWS, Rinella ME, Boursier J, Lazarus JV, Yki-Järvinen H, Loomba R. Nat Rev Dis Primers. 2025 Mar 6;11(1):14. doi: 10.1038/s41572-025-00599-1.

Hidden metabolic effects of acetyl-CoA carboxylase inhibition. Luukkonen PK. J Hepatol. 2025 Mar;82(3):544-545. doi: 10.1016/j.jhep.2024.11.043. Epub 2024 Dec 16.

Function of PNPLA3 I148M-Lessons From In Vivo Studies in Humans. Yki-Järvinen H, Luukkonen PK. Liver Int. 2025 Apr;45(4):e70047. doi: 10.1111/liv.70047.

Circulating levels of miR-20b-5p are associated with survival in cardiogenic shock. Mäntylä T, Wang C, Hänninen M, Immonen K, Jäntti T, Lassus J, Tikkanen I, Pulkki K, Devaux Y, Harjola VP, Lakkisto P; CardShock Study Investigators. J Mol Cell Cardiol Plus. 2025 Jan 17;11:100284. doi: 10.1016/j.jmccpl.2025.100284. eCollection 2025 Mar.

Proteomic profiling reveals alterations in metabolic and cellular pathways in severe obesity and following metabolic bariatric surgery. Dadson P, Honka MJ, Suomi T, Haridas PAN, Rokka A, Palani S, Goltseva E, Wang N, Roivainen A, Salminen P, James P, Olkkonen VM, Elo LL, Nuutila P. Am J Physiol Endocrinol Metab. 2025 Mar 1;328(3):E311-E324. doi: 10.1152/ajpendo.00220.2024. Epub 2025 Jan 17.

Insight into the function of the Golgi membrane protein GOLM1 in cholangiocytes through interactomic analysis. Nagaraj M, Emmagouni SKG, Chaurasiya V, Li L, Nguyen VD, Keskitalo S, Varjosalo M, Zhou Y, Haridas PAN, Olkkonen VM. FEBS Lett. 2025 Feb 1. doi: 10.1002/1873-3468.70001. Online ahead of print.

The role of Nir2, a lipid-transfer protein, in regulating endothelial cell functions. Polianskyte-Prause Z, Arora A, Taskinen JH, Chaurasiya V, Keskitalo S, Tuhkala A, Hilska I, Varjosalo M, Olkkonen VM. Biochim Biophys Acta Mol Cell Res. 2025 Feb 25;1872(3):119926. doi: 10.1016/j.bbamcr.2025.119926. Online ahead of print.

Age at type 1 diabetes onset does not influence attained brain volume. Claesson TB, Mutter S, Putaala J, Salli E, Gordin D, Groop PH, Martola J, Thorn LM. BMC Endocr Disord. 2025 Feb 18;25(1):43. doi: 10.1186/s12902-025-01868-6.

A proteomic signature of healthspan. Kuo CL, Liu P, Drouard G, Vuoksimaa E, Kaprio J, Ollikainen M, Chen Z, Pilling LC, Atkins JL, Fortinsky RH, Kuchel GA, Diniz BS. medRxiv [Preprint]. 2025 Jan 28:2024.06.26.24309530. doi: 10.1101/2024.06.26.24309530.

Suboptimal dietary patterns are associated with accelerated biological aging in young adulthood: A study with twins. Ravi S, Kankaanpää A, Bogl LH, Heikkinen A, Pietiläinen KH, Kaprio J, Ollikainen M, Sillanpää E. Clin Nutr. 2025 Feb;45:10-21. doi: 10.1016/j.clnu.2024.12.018. Epub 2024 Dec 19.

Glycemic control in women with GDM: insights from a randomized controlled pilot trial on plant-based Nordic healthy diet versus moderately carbohydrate restricted diet. Markussen LT, Kivelä J, Lindström J, Ollikainen M, Kytö M, Heinonen S, Koivusalo S, Meinilä J. BMC Nutr. 2025 Jan 16;11(1):12. doi: 10.1186/s40795-024-00988-x.

Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits. Brotman SM, El-Sayed Moustafa JS, Guan L, Broadaway KA, Wang D, Jackson AU, Welch R, Currin KW, Tomlinson M, Vadlamudi S, Stringham HM, Roberts AL, Lakka TA, Oravilahti A, Fernandes Silva L, Narisu N, Erdos MR, Yan T, Bonnycastle LL, Raulerson CK, Raza Y, Yan X, Parker SCJ, Kuusisto J, Pajukanta P, Tuomilehto J, Collins FS, Boehnke M, Love MI, Koistinen HA, Laakso M, Mohlke KL, Small KS, Scott LJ. Nat Genet. 2025 Jan;57(1):180-192. doi: 10.1038/s41588-024-01982-6. Epub 2025 Jan 2.

LAPTM4B counteracts ferroptosis via suppressing the ubiquitin-proteasome degradation of SLC7A11 in non-small cell lung cancer. Yan R, Liu D, Guo H, Liu M, Lv D, Björkblom B, Wu M, Yu H, Leng H, Lu B, Li Y, Gao M, Blom T, Zhou K. Cell Death Dis. 2024 Jun 20;15(6):436. doi: 10.1038/s41419-024-06836-x.

Transcriptomic and Metabolomic Analyses in Monozygotic and Dizygotic Twins. Hubers N, Drouard G, Jansen R, Pool R, Hottenga JJ, Ollikainen M, Wang X, Willemsen G, Kaprio J, Boomsma DI, van Dongen J. Am J Med Genet A. 2024 Dec 16:e63971. doi: 10.1002/ajmg.a.63971. Online ahead of print.

SMIM1 absence is associated with reduced energy expenditure and excess weight. Stefanucci L, Moslemi C, Tomé AR, Virtue S, Bidault G, Gleadall NS, Watson LPE, Kwa JE, Burden F, Farrow S; DBDS Genetic Consortium; Chen J; MAGIC; Võsa U, Burling K, Walker L, Ord J, Barker P, Warner J, Frary A, Renhstrom K, Ashford SE, Piper J, Biggs G, Erber WN, Hoffman GJ, Schoenmakers N, Erikstrup C, Rieneck K, Dziegiel MH, Ullum H, Azzu V, Vacca M, Aparicio HJ, Hui Q, Cho K, Sun YV, Wilson PW, Bayraktar OA, Vidal-Puig A, Ostrowski SR, Astle WJ, Olsson ML, Storry JR, Pedersen OB, Ouwehand WH, Chatterjee K, Vuckovic D, Frontini M. Med. 2024 Sep 13;5(9):1083-1095.e6. doi: 10.1016/j.medj.2024.05.015. Epub 2024 Jun 20.

Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease. Raverdy V, Tavaglione F, Chatelain E, Lassailly G, De Vincentis A, Vespasiani-Gentilucci U, Qadri SF, Caiazzo R, Verkindt H, Saponaro C, Kerr-Conte J, Baud G, Marciniak C, Chetboun M, Oukhouya-Daoud N, Blanck S, Vandel J, Olsson L, Chakaroun R, Gnemmi V, Leteurtre E, Lefebvre P, Haas JT, Yki-Järvinen H, Francque S, Staels B, Le Roux CW, Tremaroli V, Mathurin P, Marot G, Romeo S, Pattou F. Nat Med. 2024 Dec;30(12):3624-3633. doi: 10.1038/s41591-024-03283-1. Epub 2024 Dec 9.

Hidden metabolic effects of acetyl-CoA carboxylase inhibition. Luukkonen PK. J Hepatol. 2024 Dec 16:S0168-8278(24)02745-4. doi: 10.1016/j.jhep.2024.11.043. Online ahead of print.

The Value of Repeat 5-HIAA Measurements as a Predictor of Carcinoid Heart Disease: A Prospective 5-Year Follow-Up Study in Patients with Small Intestinal Neuroendocrine Tumors. Kostiainen I, Simonen P, Aaltonen K, Lindén R, Karppinen N, Gordin D, Rapola J, Schalin-Jäntti C, Matikainen N. Cancers (Basel). 2024 Nov 21;16(23):3896. doi: 10.3390/cancers16233896.

A metabolome-derived score predicts metabolic dysfunction-associated steatohepatitis and mortality from liver disease. Huang Q, Qadri SF, Bian H, Yi X, Lin C, Yang X, Zhu X, Lin H, Yan H, Chang X, Sun X, Ma S, Wu Q, Zeng H, Hu X, Zheng Y, Yki-Järvinen H, Gao X, Tang H, Xia M. J Hepatol. 2024 Oct 16:S0168-8278(24)02636-9. doi: 10.1016/j.jhep.2024.10.015. Online ahead of print.

Pre-diagnosis blood DNA methylation profiling of twin pairs discordant for breast cancer points to the importance of environmental risk factors. Bode HF, He L, Hjelmborg JVB, Kaprio J, Ollikainen M. Clin Epigenetics. 2024 Nov 18;16(1):160. doi: 10.1186/s13148-024-01767-y.

PCSK9 Antibodies Treatment Specifically Enhances the Macrophage-specific Reverse Cholesterol Transport Pathway in Heterozygous Familial Hypercholesterolemia. Borràs C, Canyelles M, Girona J, Ibarretxe D, Santos D, Revilla G, Llorente-Cortes V, Rotllan N, Kovanen PT, Jauhiainen M, Lee-Rueckert M, Masana L, Arrieta F, Martínez-Botas J, Gómez-Coronado D, Ribalta J, Tondo M, Blanco-Vaca F, Escolà-Gil JC. JACC Basic Transl Sci. 2024 Aug 28;9(10):1195-1210. doi: 10.1016/j.jacbts.2024.06.008. eCollection 2024 Oct.

Circulating hsa-miR-320a and its regulatory network in type 1 diabetes mellitus. Nizam R, Malik MZ, Jacob S, Alsmadi O, Koistinen HA, Tuomilehto J, Alkandari H, Al-Mulla F, Thanaraj TA. Front Immunol. 2024 Oct 11;15:1376416. doi: 10.3389/fimmu.2024.1376416. eCollection 2024.

Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations. Salo V, Määttä J, Sliz E; FinnGen; Reimann E, Mägi R; Estonian Biobank Research Team; Reis K, Elhanas AG, Reigo A, Palta P, Esko T, Karppinen J, Kettunen J. Nat Commun. 2024 Nov 7;15(1):9424. doi: 10.1038/s41467-024-53467-z.

A sham-controlled randomised pilot trial on baroreflex activation therapy in patients with resistant hypertension: What will the future hold? Gordin D, Simonsen R, Tikkanen I. Blood Press. 2024 Dec;33(1):2417887. doi: 10.1080/08037051.2024.2417887. Epub 2024 Oct 23.

The role of dietary modification in the prevention and management of metabolic dysfunction-associated fatty liver disease: An international multidisciplinary expert consensus. Zeng XF, Varady KA, Wang XD, Targher G, Byrne CD, Tayyem R, Latella G, Bergheim I, Valenzuela R, George J, Newberry C, Zheng JS, George ES, Spearman CW, Kontogianni MD, Ristic-Medic D, Peres WAF, Depboylu GY, Yang W, Chen X, Rosqvist F, Mantzoros CS, Valenti L, Yki-Järvinen H, Mosca A, Sookoian S, Misra A, Yilmaz Y, Kim W, Fouad Y, Sebastiani G, Wong VW, Åberg F, Wong YJ, Zhang P, Bermúdez-Silva FJ, Ni Y, Lupsor-Platon M, Chan WK, Méndez-Sánchez N, de Knegt RJ, Alam S, Treeprasertsuk S, Wang L, Du M, Zhang T, Yu ML, Zhang H, Qi X, Liu X, Pinyopornpanish K, Fan YC, Niu K, Jimenez-Chillaron JC, Zheng MH. Metabolism. 2024 Dec;161:156028. doi: 10.1016/j.metabol.2024.156028. Epub 2024 Sep 11.

Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles. Drouard G, Wang Z, Heikkinen A, Foraster M, Julvez J, Kanninen KM, van Kamp I, Pirinen M, Ollikainen M, Kaprio J. Sci Rep. 2024 Sep 11;14(1):21261. doi: 10.1038/s41598-024-72354-7.

A novel long non-coding RNA connects obesity to impaired adipocyte function. Lluch A, Latorre J, Oliveras-Cañellas N, Fernández-Sánchez A, Moreno-Navarrete JM, Castells-Nobau A, Comas F, Buxò M, Rodríguez-Hermosa JI, Ballester M, Espadas I, Martin-Montalvo A, Zhang B, Zhou Y, Burkhardt R, Höring M, Liebisch G, Castellanos-Rubio A, Santin I, Kar A, Laakso M, Pajukanta P, Olkkonen VM, Fernández-Real JM, Ortega FJ. Mol Metab. 2024 Oct 1:102040. doi: 10.1016/j.molmet.2024.102040. Online ahead of print.

CNPY2 protects against ER stress and is expressed by corticostriatal neurons together with CTIP2 in a mouse model of Huntington’s disease. Scordino M, Stepanova P, Srinivasan V, Pham DD, Eriksson O, Lalowski M, Mudò G, Di Liberto V, Korhonen L, Voutilainen MH, Lindholm D. Front Mol Neurosci. 2024 Sep 18;17:1473058. doi: 10.3389/fnmol.2024.1473058. eCollection 2024.

Cholesterol binding to VCAM-1 promotes vascular inflammation. Kennelly JP, Xiao X, Gao Y, Kim S, Hong SG, Villanueva M, Ferrari A, Vanharanta L, Nguyen A, Nagari RT, Burton NR, Tol MJ, Becker AP, Lee MJ, Ikonen E, Backus KM, Mack JJ, Tontonoz P. bioRxiv [Preprint]. 2024 Sep 18:2024.09.17.613543. doi: 10.1101/2024.09.17.613543.

Altered oxidant and antioxidant levels are associated with vascular stiffness and diabetic kidney disease in type 1 diabetes after exposure to acute and chronic hyperglycemia. Adeshara K, Di Marco E, Bordino M, Gordin D, Bernardi L, Cooper ME, Groop PH; FinnDiane Study Group. Cardiovasc Diabetol. 2024 Sep 28;23(1):350. doi: 10.1186/s12933-024-02427-4.

Genetic susceptibility to acute viral bronchiolitis. Pasanen A, Karjalainen MK, Korppi M, Hallman M, Rämet M; Research Project FinnGen. J Infect Dis. 2024 Sep 20:jiae467. doi: 10.1093/infdis/jiae467. Online ahead of print.

Protein Phosphatase 1 Regulatory Subunit 3 Beta rs4240624 Genotype Is Associated With Gallstones and With Significant Changes in Bile Lipidome. Männistö VT, Kaminska D, Haal S, Asteljoki J, Luukkonen PK, Käkelä P, Tavaglione F, van Weeghel M, Neuvonen M, Niemi M, Romeo S, Nieuwdorp M, Pihlajamäki J, Groen AK. Gastro Hep Adv. 2024 Mar 12;3(5):594-601. doi: 10.1016/j.gastha.2024.03.005. eCollection 2024.

Cardiac Structure and Function in 8- to 12-Year-Old Children Following In-Utero Exposure to Preeclampsia (FINNCARE Study). Renlund-Vikström M, Jääskeläinen TJ, Kivelä A, Heinonen S, Laivuori H, Sarkola T. J Am Heart Assoc. 2024 Aug 6;13(15):e034494. doi: 10.1161/JAHA.124.034494. Epub 2024 Jul 16.

A Bivariate Twin Study of Lifetime cannabis Initiation and Lifetime Regular Tobacco Smoking Across Three Different Countries. Zellers S, van Dongen J, Maes HHM, Ollikainen M, Fang F, Vrieze S, Kaprio J, Boomsma DI. Behav Genet. 2024 Sep;54(5):375-385. doi: 10.1007/s10519-024-10190-1. Epub 2024 Jul 30.

Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult. Di Nunzio G, Hellberg S, Zhang Y, Ahmed O, Wang J, Zhang X, Björck HM, Chizh V, Schipper R, Aulin H, Francis R, Fagerberg L, Gisterå A, Metso J, Manfé V, Franco-Cereceda A, Eriksson P, Jauhiainen M, Hagberg CE, Olofsson PS, Malin SG. Nat Cardiovasc Res. 2024 Mar;3(3):356-371.

Fluid bolus increases plasma hyaluronan concentration compared to follow-up strategy without a bolus in oliguric intensive care unit patients. Serlo M, Inkinen N, Lakkisto P, Valkonen M, Pulkkinen A, Selander T, Pettilä V, Vaara ST. Sci Rep. 2024 Sep 6;14(1):20808. doi: 10.1038/s41598-024-71670-2.

Circulating microRNAs targeting coagulation and fibrinolysis in patients with severe COVID-19. Helin TA, Lemponen M, Immonen K, Lakkisto P, Joutsi-Korhonen L. Thromb J. 2024 Sep 5;22(1):80. doi: 10.1186/s12959-024-00649-w.

Guidelines for mitochondrial RNA analysis. Jusic A, Erpapazoglou Z, Dalgaard LT, Lakkisto P, de Gonzalo-Calvo D, Benczik B, Ágg B, Ferdinandy P, Fiedorowicz K, Schroen B, Lazou A, Devaux Y; EU-CardioRNA COST Action CA17129; AtheroNET COST Action CA21153. Mol Ther Nucleic Acids. 2024 Jun 26;35(3):102262. doi: 10.1016/j.omtn.2024.102262. eCollection 2024 Sep 10.

Soybean oil-based HFD induces gut dysbiosis that leads to steatosis, hepatic inflammation and insulin resistance in mice. Jacob T, Sindhu S, Hasan A, Malik MZ, Arefanian H, Al-Rashed F, Nizam R, Kochumon S, Thomas R, Bahman F, Shenouda S, Wilson A, Akther N, Al-Roub A, Abukhalaf N, Albeloushi S, Abu-Farha M, Al Madhoun A, Alzaid F, Thanaraj TA, Koistinen HA, Tuomilehto J, Al-Mulla F, Ahmad R. Front Microbiol. 2024 Aug 6;15:1407258. doi: 10.3389/fmicb.2024.1407258. eCollection 2024.

Analysis of early-pregnancy metabolome in early- and late-onset gestational diabetes reveals distinct associations with maternal overweight. Masalin S, Klåvus A, Rönö K, Koistinen HA, Koistinen V, Kärkkäinen O, Jääskeläinen TJ, Klemetti MM. Diabetologia. 2024 Jul 31. doi: 10.1007/s00125-024-06237-x. Online ahead of print.

Gut Dysbiosis Shaped by Cocoa Butter-Based Sucrose-Free HFD Leads to Steatohepatitis, and Insulin Resistance in Mice. Kochumon S, Malik MZ, Sindhu S, Arefanian H, Jacob T, Bahman F, Nizam R, Hasan A, Thomas R, Al-Rashed F, Shenouda S, Wilson A, Albeloushi S, Almansour N, Alhamar G, Al Madhoun A, Alzaid F, Thanaraj TA, Koistinen HA, Tuomilehto J, Al-Mulla F, Ahmad R. Nutrients. 2024 Jun 18;16(12):1929. doi: 10.3390/nu16121929.

Adipogenin Dictates Adipose Tissue Expansion by Facilitating the Assembly of a Dodecameric Seipin Complex. Li C, Sun XN, Funcke JB, Vanharanta L, Joffin N, Li Y, Prasanna X, Paredes M, Joung C, Gordillo R, Vörös C, Kulig W, Straub L, Chen S, Velasco J, Cobb A, Padula D, Wang MY, Onodera T, Varlamov O, Li Y, Liu C, Nawrocki AR, Zhao S, Oh DY, Wang ZV, Goodman JM, Wynn RM, Vattulainen I, Han Y, Ikonen E, Scherer PE. bioRxiv [Preprint]. 2024 Jul 26:2024.07.25.605195. doi: 10.1101/2024.07.25.605195.

Getting to Grips with the Oxysterol-Binding Protein Family – a Forty Year Perspective. Olkkonen VM, Ikonen E. Contact (Thousand Oaks). 2024 Aug 28;7:25152564241273598. doi: 10.1177/25152564241273598. eCollection 2024 Jan-Dec.

Sham-Controlled Randomized Pilot Trial on Baroreflex Activation Therapy in Resistant Hypertension. Simonsen JR, Vikatmaa L, Vikatmaa P, Laine M, Granroth-Wilding H, Groop PH, Tikkanen I, Gordin D. Hypertension. 2024 Aug;81(8):e91-e93. doi: 10.1161/HYPERTENSIONAHA.124.23088. Epub 2024 Jul 17.

Protein glycation products associate with progression of kidney disease and incident cardiovascular events in individuals with type 1 diabetes. Adeshara K, Gordin D, Antikainen AA, Harjutsalo V, Sandholm N, Lehto MJ, Groop PH; FinnDiane Study Group. Cardiovasc Diabetol. 2024 Jul 4;23(1):235. doi: 10.1186/s12933-024-02316-w.

Activation of the hypoxia-inducible factor pathway by roxadustat improves glucose metabolism in human primary myotubes from men. Mäkinen S, Sree S, Ala-Nisula T, Kultalahti H, Koivunen P, Koistinen HA. Diabetologia. 2024 May 30. doi: 10.1007/s00125-024-06185-6. Online ahead of print.

IRE1α Mediates the Hypertrophic Growth of Cardiomyocytes Through Facilitating the Formation of Initiation Complex to Promote the Translation of TOP-Motif Transcripts. Li C, Li S, Zhang G, Li Q, Song W, Wang X, Cook JA, van der Stoel M, Wright BW, Altamirano F, Niewold EL, Han J, Kimble G, Zhang P, Luo X, Urra H, May HI, Ferdous A, Sun XN, Deng Y, Ikonen E, Hetz C, Kaufman RJ, Zhang K, Gillette TG, Scherer PE, Hill JA, Chen J, Wang ZV. Circulation. 2024 Jun 5. doi: 10.1161/CIRCULATIONAHA.123.067606. Online ahead of print.

Actin polymerization and longitudinal actin fibers in axon initial segment plasticity. Micinski D, Hotulainen P. Front Mol Neurosci. 2024 May 10;17:1376997. doi: 10.3389/fnmol.2024.1376997. eCollection 2024.

TWINGEN: protocol for an observational clinical biobank recall and biomarker cohort study to identify Finnish individuals with high risk of Alzheimer’s disease. Vuoksimaa E, Saari TT, Aaltonen A, Aaltonen S, Herukka SK, Iso-Markku P, Kokkola T, Kyttälä A, Kärkkäinen S, Liedes H, Ollikainen M, Palviainen T, Ruotsalainen I, Toivola A, Urjansson M, Vasankari T, Vähä-Ypyä H, Forsberg MM, Hiltunen M, Jalanko A, Kälviäinen R, Kuopio T, Lähteenmäki J, Nyberg P, Männikkö M, Serpi R, Siltanen S, Palotie A, Kaprio J, Runz H, Julkunen V; FinnGen. BMJ Open. 2024 Jun 12;14(6):e081947. doi: 10.1136/bmjopen-2023-081947.

Colonocyte keratins stabilize mitochondria and contribute to mitochondrial energy metabolism. Nyström JH, Heikkilä TRH, Thapa K, Pulli I, Törnquist K, Toivola DM. Am J Physiol Gastrointest Liver Physiol. 2024 Jun 11. doi: 10.1152/ajpgi.00220.2023. Online ahead of print.

Exploring machine learning strategies for predicting cardiovascular disease risk factors from multi-omic data. Drouard G, Mykkänen J, Heiskanen J, Pohjonen J, Ruohonen S, Pahkala K, Lehtimäki T, Wang X, Ollikainen M, Ripatti S, Pirinen M, Raitakari O, Kaprio J. BMC Med Inform Decis Mak. 2024 May 2;24(1):116. doi: 10.1186/s12911-024-02521-3.

Nature and Nurture in Familial Aggregation of Steatotic Liver Disease. Asteljoki J, Luukkonen PK. Clin Gastroenterol Hepatol. 2024 Apr 6:S1542-3565(24)00306-9. doi: 10.1016/j.cgh.2024.03.024. Online ahead of print.

Cumulative risk factors for injuries and poisoning requiring hospital care in youth with prenatal substance exposure: A longitudinal controlled cohort study. Koponen AM, Gissler M, Nissinen NM, Autti-Rämö I, Kahila H, Sarkola T. Nordisk Alkohol Nark. 2024 Apr;41(2):156-174. doi: 10.1177/14550725231202074.

Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complications. Christiansen C, Potier L, Martin TC, Villicaña S, Castillo-Fernandez JE, Mangino M, Menni C, Tsai PC, Campbell PJ, Mullin S, Ordoñana JR, Monteagudo O, Sachdev PS, Mather KA, Trollor JN, Pietilainen KH, Ollikainen M, Dalgård C, Kyvik K, Christensen K, van Dongen J, Willemsen G, Boomsma DI, Magnusson PKE, Pedersen NL, Wilson SG, Grundberg E, Spector TD, Bell JT. EBioMedicine. 2024 May;103:105096. doi: 10.1016/j.ebiom.2024.105096. Epub 2024 Apr 4.

Antidepressant Exposure and DNA Methylation: Insights from a Methylome-Wide Association Study. Davyson E, Shen X, Huider F, Adams M, Borges K, McCartney D, Barker L, Van Dongen J, Boomsma D, Weihs A, Grabe H, Kühn L, Teumer A, Völzke H, Zhu T, Kaprio J, Ollikainen M, David FS, Meinert S, Stein F, Forstner AJ, Dannlowski U, Kircher T, Tapuc A, Czamara D, Binder EB, Brückl T, Kwong A, Yousefi P, Wong C, Arseneault L, Fisher HL, Mill J, Cox S, Redmond P, Russ TC, van den Oord E, Aberg KA, Penninx B, Marioni RE, Wray NR, McIntosh AM. medRxiv [Preprint]. 2024 May 3:2024.05.01.24306640. doi: 10.1101/2024.05.01.24306640.

Evaluating the correlation of sclerostin levels with obesity and type 2 diabetes in a multiethnic population living in Kuwait. Alramah T, Cherian P, Al-Khairi I, Abu-Farha M, Thanaraj TA, Albatineh AN, Safadi F, Ali H, Abdul-Ghani M, Tuomilehto J, Koistinen HA, Al-Mulla F, Abubaker J. Front Endocrinol (Lausanne). 2024 Apr 22;15:1392675. doi: 10.3389/fendo.2024.1392675. eCollection 2024.

Ethnic Variations in the Levels of Bone Biomarkers (Osteoprostegerin, Receptor Activator of Nuclear Factor Kappa-Β Ligand and Glycoprotein Non-Metastatic Melanoma Protein B) in People with Type 2 Diabetes. Cherian P, Al-Khairi I, Abu-Farha M, Alramah T, Albatineh AN, Alhomaidah D, Safadi F, Ali H, Abdul-Ghani M, Tuomilehto J, Koistinen HA, Al-Mulla F, Abubaker J. Biomedicines. 2024 May 6;12(5):1019. doi: 10.3390/biomedicines12051019.

Combination therapy for kidney disease in people with diabetes mellitus. van Raalte DH, Bjornstad P, Cherney DZI, de Boer IH, Fioretto P, Gordin D, Persson F, Rosas SE, Rossing P, Schaub JA, Tuttle K, Waikar SS, Heerspink HJL. Nat Rev Nephrol. 2024 Apr 3. doi: 10.1038/s41581-024-00827-z. Online ahead of print.

A Clinical Study on Urinary Clusterin and Cystatin B in Dogs with Spontaneous Acute Kidney Injury. Gordin E, Viitanen S, Gordin D, Szlosek D, Peterson S, Spillmann T, Labato MA. Vet Sci. 2024 May 2;11(5):200. doi: 10.3390/vetsci11050200.

Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function. Wang H, Siren J, Perttunen S, Immonen K, Chen YC, Narumanchi S, Kosonen R, Paavola J, Laine M, Tikkanen I, Lakkisto P. J Cell Mol Med. 2024 Apr;28(7):e18243. doi: 10.1111/jcmm.18243.

Surveillance of the liver in type 2 diabetes: important but unfeasible? Qadri S, Yki-Järvinen H. Diabetologia. 2024 Feb 9. doi: 10.1007/s00125-024-06087-7. Online ahead of print.

IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids. Sasidharan K, Caddeo A, Jamialahmadi O, Noto FR, Tomasi M, Malvestiti F, Ciociola E, Tavaglione F, Mancina RM, Cherubini A, Bianco C, Mirarchi A, Männistö V, Pihlajamäki J, Kärjä V, Grimaudo S, Luukkonen PK, Qadri S, Yki-Järvinen H, Petta S, Manfrini S, Vespasiani-Gentilucci U, Bruni V, Valenti L, Romeo S. Cell Rep Med. 2024 Jan 16;5(1):101352. doi: 10.1016/j.xcrm.2023.101352.

Hepatic mitochondrial reductive stress in the pathogenesis and treatment of steatotic liver disease. Jokinen MJ, Luukkonen PK. Trends Pharmacol Sci. 2024 Mar 11:S0165-6147(24)00030-0. doi: 10.1016/j.tips.2024.02.003. Online ahead of print.

Metabolic syndrome and epigenetic aging: a twin study. Föhr T, Hendrix A, Kankaanpää A, Laakkonen EK, Kujala U, Pietiläinen KH, Lehtimäki T, Kähönen M, Raitakari O, Wang X, Kaprio J, Ollikainen M, Sillanpää E. Int J Obes (Lond). 2024 Jan 25. doi: 10.1038/s41366-024-01466-x. Online ahead of print.

Effects of fat loss and low energy availability on the serum cardiometabolic profile of physique athletes. Jouhki I, Sarin HV, Jauhiainen M, O’Connell TM, Isola V, Ahtiainen JP, Hulmi JJ, Perola M. Scand J Med Sci Sports. 2024 Jan;34(1):e14553. doi: 10.1111/sms.14553.

GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines. Nummela P, Zafar S, Veikkolainen E, Ukkola I, Cinella V, Ayo A, Asghar MY, Välimäki N, Törnquist K, Karhu A, Laakkonen P, Aaltonen LA, Ristimäki A. Int J Cancer. 2024 Feb 6. doi: 10.1002/ijc.34865. Online ahead of print.

Adipocyte-endothelial cell interplay in adipose tissue physiology. Chaurasiya V, Nidhina Haridas PA, Olkkonen VM. Biochem Pharmacol. 2024 Feb 24;222:116081. doi: 10.1016/j.bcp.2024.116081. Online ahead of print.

miR-619-5p and cardiogenic shock in patients with ST-segment elevation myocardial infarction. Escate R, Padró T, Suades R, Sans-Roselló J, Devaux Y, Lakkisto P, Harjola VP, Sionis A, Badimon L. Eur J Clin Invest. 2024 Feb 20:e14186. doi: 10.1111/eci.14186. Online ahead of print.

HiHo-AID2: boosting homozygous knock-in efficiency enables robust generation of human auxin-inducible degron cells. Li S, Wang Y, van der Stoel M, Zhou X, Madhusudan S, Kanerva K, Nguyen VD, Eskici N, Olkkonen VM, Zhou Y, Raivio T, Ikonen E. Genome Biol. 2024 Feb 26;25(1):58. doi: 10.1186/s13059-024-03187-w.

Sex-specific genetic risks for adverse outcomes after coronary revascularization procedures. Nurkkala JM, Aittokallio J; FinnGen; Kauko A, Niiranen T. Interdiscip Cardiovasc Thorac Surg. 2024 Jan 2;38(1):ivae006. doi: 10.1093/icvts/ivae006.

High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases. Youssef O, Loukola A, Zidi-Mouaffak YHS, Tamlander M, Ruotsalainen S, Kilpeläinen E, Mars N, Ripatti S; FinnGen; Palotie A, Donner K, Carpén O. Lab Invest. 2024 Jan 14;104(4):100325. doi: 10.1016/j.labinv.2024.100325. Online ahead of print.

Retinal artery to vein ratio is associated with cerebral microbleeds in individuals with type 1 diabetes. Tarkkonen A, Fickweiler W, Eriksson M, Sun JK, Thorn LM, Summanen P, Groop PH, Putaala J, Martola J, Gordin D; FinnDiane Study Group. J Hypertens. 2024 Feb 28. doi: 10.1097/HJH.0000000000003690. Online ahead of print.

Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women. Mars N, Kerminen S, Tamlander M, Pirinen M, Jakkula E, Aaltonen K, Meretoja T, Heinävaara S, Widén E, Ripatti S; FinnGen. J Clin Oncol. 2024 Feb 29:JCO2300295. doi: 10.1200/JCO.23.00295. Online ahead of print.

Oxy- and Phytosterols as Biomarkers: Current Status and Future Perspectives. Olkkonen VM, Gylling H. Adv Exp Med Biol. 2024;1440:353-375. doi: 10.1007/978-3-031-43883-7_18.

Preeclampsia-exposed children’s heart rate variability 8-12 yr after index pregnancy: FINNCARE study. Renlund M, Tulppo MP, Kivelä A, Laivuori H, Heinonen S, Jääskeläinen T, Sarkola T. Am J Physiol Heart Circ Physiol. 2024 Jan 1;326(1):H74-H81. doi: 10.1152/ajpheart.00540.2023. Epub 2023 Nov 3.