Latest publications

Long-term impact of stressful life events on breast cancer risk: A 36-year genetically informed prospective study in the Finnish Twin Cohort. Azzi E, Bode H, Palviainen T, Hukkanen M, Ollikainen M, Kaprio J. Int J Cancer. 2025 Sep 13. doi: 10.1002/ijc.70154. Online ahead of print.

Insights into the vascular aging burden in young adults with embolic stroke of undetermined source. Kakaletsis N, Gordin D, Martinez-Majander N, Joutsi-Korhonen L, Salopuro T, Adeshara K, Sibolt G, Curtze S, Pirinen J, Soinne L, Sairanen T, Suihko S, Lehto M, Sinisalo J, Tatlisumak T, Groop PH, Putaala J. J Neurol Sci. 2025 Sep 15;476:123642. doi: 10.1016/j.jns.2025.123642. Epub 2025 Jul 28.

TOM1 G307D variant impairs interaction with TOLLIP, autophagosome-lysosome fusion and regulation of innate immunity. Lång HKM, Roach TG, Hölttä M, Keskitalo S, Varjosalo M, Heiskanen K, Collins MV, Seppänen MRJ, Capelluto DGS, Ikonen E, Ryhänen SJ. Dis Model Mech. 2025 Sep 12:dmm.052140. doi: 10.1242/dmm.052140. Online ahead of print.TOM1 G307D variant impairs interaction with TOLLIP, autophagosome-lysosome fusion and regulation of innate immunity. Lång HKM, Roach TG, Hölttä M, Keskitalo S, Varjosalo M, Heiskanen K, Collins MV, Seppänen MRJ, Capelluto DGS, Ikonen E, Ryhänen SJ. Dis Model Mech. 2025 Sep 12:dmm.052140. doi: 10.1242/dmm.052140. Online ahead of print.

Kinase inhibitor boosts liver regeneration and prevents liver failure. Luukkonen PK. J Hepatol. 2025 Sep 5:S0168-8278(25)02445-6. doi: 10.1016/j.jhep.2025.08.010. Online ahead of print.

Current Status of Fetal Echocardiography Imaging and Fetal Counseling Fellow Training in 29 European Countries. Sarkola T, Seale AN, Tulzer A, Duignan SM, Grzyb A, Tuo G, Vanhie E, McMahon CJ; Fetal Cardiology Working Group of the AEPC. Pediatr Cardiol. 2025 Sep 1. doi: 10.1007/s00246-025-04006-0. Online ahead of print.

Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol. Zhou X, van der Stoel MM, Kaptan S, Li H, Li S, Hölttä M, Vihinen H, Jokitalo E, Thiele C, Pietiläinen O, Morioka S, Sasaki J, Sasaki T, Vattulainen I, Ikonen E. Nat Commun. 2025 Aug 21;16(1):7808. doi: 10.1038/s41467-025-63125-7.

Heme oxygenase-1 polymorphisms associate with ischemic cardiac complications and all-cause mortality in type 1 diabetes. Segersvärd H, Sandholm N, Harjutsalo V, Tikkanen H, Kosonen R, Laine M, Tikkanen I, Groop PH, Lakkisto P; FinnDiane Study Group. Cardiovasc Diabetol. 2025 Aug 18;24(1):339. doi: 10.1186/s12933-025-02895-2.

Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty. Mak JKL, Qin C, Krüger M, Kuukka A; FinnGen; Hägg S, Lin J, Jylhävä J. Nat Aging. 2025 Aug;5(8):1589-1600. doi: 10.1038/s43587-025-00925-y. Epub 2025 Aug 5.

Precision in Liver Diagnosis: Varied Accuracy Across Subgroups and the Need for Variable Thresholds in Diagnosis of MASLD. Vali Y, van Dijk AM, Lee J, Boursier J, Ratziu V, Yunis C, Schattenberg JM, Valenti L, Gomez MR, Schuppan D, Petta S, Allison M, Hartman ML, Porthan K, Dufour JF, Bugianesi E, Gastadelli A, Derdak Z, Fournier-Poizat C, Shumbayawonda E, Kalutkiewicz M, Yki-Jarvinen H, Ekstedt M, Geier A, Trylesinski A, Francque S, Brass C, Pavlides M, Holleboom AG, Nieuwdorp M, Anstee QM, Bossuyt PM; LITMUS investigators. Liver Int. 2025 Feb;45(2):e16240. doi: 10.1111/liv.16240.

Polygenic prediction of body mass index and obesity through the life course and across ancestries. Smit RAJ, Wade KH, Hui Q, Arias JD, Yin X, Christiansen MR, Yengo L, Preuss MH, Nakabuye M, Rocheleau G, Graham SE, Buchanan VL, Chittoor G, Graff M, Guindo-Martínez M, Lu Y, Marouli E, Sakaue S, Spracklen CN, Vedantam S, Wilson EP, Chen SH, Ferreira T, Ji Y, Karaderi T, Lüll K, Machado M, Malden DE, Medina-Gomez C, Moore A, Rüeger S, Akiyama M, Allison MA, Alvarez M, Andersen MK, Appadurai V, Arbeeva L, Bartell E, Bhaskar S, Bielak LF, Bis JC, Bollepalli S, Bork-Jensen J, Bradfield JP, Bradford Y, Brandl C, Braund PS, Brody JA, Broeckel U, Burgdorf KS, Cade BE, Cai Q, Camarda S, Campbell A, Cañadas-Garre M, Chai JF, Chesi A, Choi SH, Christofidou P, Couture C, Cuellar-Partida G, Danning R, Degenhardt F, Delgado GE, Delitala A, Demirkan A, Deng X, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Eichelmann F, Eliasen AU, Engmann JE, Erdos MR, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Frank M, Freitag-Wolf S, Fritsche LG, Fuchsberger C, Galesloot TE, Gao Y, Geller F, Giannakopoulou O, Giulianini F, Gjesing AP, Goel A, Gordon SD, Gorski M, Grove J, Guo X, Gustafsson S, Haessler J, Hansen TF, Havulinna AS, Haworth SJ, Heard-Costa N, Hemerich D, Highland HM, Hi…See abstract for full author list ➔ Nat Med. 2025 Jul 21. doi: 10.1038/s41591-025-03827-z. Online ahead of print.

No evidence from euglycaemic-hyperinsulinaemic clamp studies for greater insulin sensitivity in adults with type 1 diabetes using insulin pump versus multiple daily insulin injections-Post hoc meta-analysis. Januszewski AS, Snaith JR, Grzelka-Wozniak A, Simonsen JRA, Sachithanandan N, Ward GM, O’Neal DN, Gordin D, Thorn LM, Groop PH, Uruska AA, Zozulinska-Ziolkiewicz DA, Jenkins AJ, Greenfield JR. Diabetes Obes Metab. 2025 Jul 1. doi: 10.1111/dom.16487. Online ahead of print.

Tirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT-MMO trial. Lam CSP, Rodriguez A, Aminian A, Ferrannini E, Heerspink HJL, Jastreboff AM, Laffin LJ, Pandey A, Ray KK, Ridker PM, Sanyal AJ, Yki-Jarvinen H, Mason D, Strzelecki M, Bartee AK, Cui C, Hurt K, Linetzky B, Bunck MC, Nissen SE. Obesity (Silver Spring). 2025 Jun 22. doi: 10.1002/oby.24332. Online ahead of print.

Genetic Loci Associated With Periodontitis: The FinnGen Study Based on National Health Registers. Salminen A, Hyvärinen K, Ritari J, Caetano A, Kambur O, Mäntylä P, Yilmaz M, Sinisalo J; FinnGen; Perola M, Havulinna A, Nibali L, Gürsoy UK, Pussinen PJ. J Clin Periodontol. 2025 Jul 19. doi: 10.1111/jcpe.14193. Online ahead of print.

Sympathetic activation of adipose tissue lipolysis underlies overnutrition-induced metabolic dysfunction. Luukkonen PK. J Hepatol. 2025 Jun 18:S0168-8278(25)02252-4. doi: 10.1016/j.jhep.2025.05.021. Online ahead of print.

Impact of different hypertensive disorders of pregnancy on cardiovascular disease risk and all-cause mortality in women with type 1 diabetes. Rimpeläinen K, Jansson Sigfrids F, Gordin D, Klemetti MM, Harjutsalo V, Groop PH, Thorn LM; FinnDiane Study Group. Cardiovasc Diabetol. 2025 Jun 14;24(1):255. doi: 10.1186/s12933-025-02804-7.

A proteomic signature of healthspan. Kuo CL, Liu P, Drouard G, Vuoksimaa E, Kaprio J, Ollikainen M, Chen Z, Pilling LC, Atkins JL, Fortinsky RH, Kuchel GA, Diniz BS. Proc Natl Acad Sci U S A. 2025 Jun 10;122(23):e2414086122.

Cardiometabolic health 8-12 years after pre-eclampsia: Role of obesity and gestational diabetes (FINNCARE study). Kivelä A, Renlund-Vikström M, Heinonen S, Sarkola T, Laivuori H, Jääskeläinen T. Pregnancy Hypertens. 2025 Jun 9;41:101226. doi: 10.1016/j.preghy.2025.101226. Online ahead of print.

Genome-wide interaction study with BMI identifies CYP7A1 and GIPR as genetic modulators of MASLD. Jamialahmadi O, Mujica E, Morris L, Mancina RM, Ciociola E, Qadri SF, Maurotti S, Malvestiti F, Li-Gao R, Ronzoni L, Tavaglione F, Maude H, Allalou A, Emmanouilidou A, Vespasiani-Gentilucci U, Rosendaal FR, Yki-Järvinen H, Cebola I, Valenti L, den Hoed M, Romeo S. Clin Mol Hepatol. 2025 Jun 2. doi: 10.3350/cmh.2025.0159. Online ahead of print.

Protein Associations With Alcohol Consumption and Genetic Risk for Alcohol-Related Sociomedical Conditions. Drouard G, Palviainen T, Kuo CL, Diniz BS, Wang X, Ollikainen M, Latvala A, Kaprio J. Addict Biol. 2025 Jun;30(6):e70045. doi: 10.1111/adb.70045.

Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration. Jacques M, Landen S, Sharples AP, Garnham A, Schittenhelm R, Steele J, Heikkinen A, Sillanpää E, Ollikainen M, Broatch J, Zarekookandeh N, Hanson O, Ekström O, Asplund O, Lamon S, Alexander SE, Smith C, Bauer C, Woessner MN, Levinger I, Teschendorff AE, Gillberg L, Blom I, Helge JW, Harvey NR, Haupt LM, Griffiths LR, Deshmukh AS, Pietiläinen KH, Piirilä P, Seaborne RAE, Klevjer M, Bye A, Wisløff U, Jones-Freeman B, Eynon N. Cell Rep. 2025 Jun 24;44(6):115750. doi: 10.1016/j.celrep.2025.115750. Epub 2025 May 28.

Twin Study Provides Heritability Estimates for 2321 Plasma Proteins and Assesses Missing SNP Heritability. Drouard G, Hagenbeek FA, Ollikainen M, Zheng Z, Wang X; FinnGen; Ripatti S, Pirinen M, Kaprio J. J Proteome Res. 2025 Jun 6;24(6):2689-2697. doi: 10.1021/acs.jproteome.4c00971. Epub 2025 May 27.

Pediatric heart transplantation within the Scandiatransplant region-a multinational observational study spanning 38 years. van der Have O, Tran-Lundmark K, Wåhlander H, Kaskinen AK, Möller T, Juul K, Jahnukainen T, Weinreich ID, Sarkola T, Nilsson J, Odermarsky M. J Heart Lung Transplant. 2025 Jun 5:S1053-2498(25)02024-8. doi: 10.1016/j.healun.2025.05.020. Online ahead of print.

Tricaine, eugenol and etomidate for repetitive procedural anesthesia in adult zebrafish, Danio rerio: effect on stress and behavior. Narumanchi S, Perttunen S, Laine P, Kosonen R, Lakkisto P, Laine M, Tikkanen I, Paavola J. Front Vet Sci. 2025 May 14;12:1562425. doi: 10.3389/fvets.2025.1562425. eCollection 2025.

Genome-wide association study of anterior uveitis. Koskimäki F, Ahokas O, Kajanne R, Saviauk KR, Elnahas A, Reigo A, Reis K, Esko T, Palta P, Leinonen S, Kettunen J, Liinamaa J, Karjalainen MK, Saarela V; Estonian Biobank Research Team Consortium, FinnGen Consortium; FinnGen Consortium. Br J Ophthalmol. 2025 May 30;109(6):660-667. doi: 10.1136/bjo-2024-326037.

Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity. Heikkinen A, Esser VFC, Lee SHT, Lundgren S, Hakkarainen A, Lundbom J, Kuula J, Groop PH, Heinonen S, Villicaña S, Bell JT, Maguolo A, Nilsson E, Ling C, Vaag A, Pajukanta P, Kaprio J, Pietiläinen KH, Li S, Ollikainen M. Nat Commun. 2025 May 12;16(1):4374. doi: 10.1038/s41467-025-59576-7.

Proteomic associations with fluctuation and long-term changes in BMI: A 40-year follow-up study. Obeso A, Drouard G, Palviainen T, Wang X, Ollikainen M, Silventoinen K, Kaprio J. Diabetes Obes Metab. 2025 Aug;27(8):4192-4202. doi: 10.1111/dom.16448. Epub 2025 May 8.

Multi-Omic Associations of Epigenetic Age Acceleration Are Heterogeneously Shaped by Genetic and Environmental Influences. Drouard G, Suhonen S, Heikkinen A, Wang Z, Kaprio J, Ollikainen M. Aging Cell. 2025 May 5:e70088. doi: 10.1111/acel.70088. Online ahead of print.

Progression of Cerebral Small Vessel Disease Among Neurologically Asymptomatic Middle-Aged Individuals With Type 1 Diabetes. Tarkkonen A, Kyläheiko I, Inkeri J, Eriksson MI, Thorn LM, Summanen PA, Tatlisumak T, Groop PH, Putaala J, Gordin D, Martola J; FinnDiane Study Group. Diabetes Care. 2025 May 1;48(5):776-780. doi: 10.2337/dc24-1825.

Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease. Martiskainen H, Willman RM, Harju P, Heikkinen S, Heiskanen M, Müller SA, Sinisalo R, Takalo M, Mäkinen P, Kuulasmaa T, Pekkala V, Galván Del Rey A, Juopperi SP, Jeskanen H, Kervinen I, Saastamoinen K; FinnGen; Niiranen M, Heikkinen SV, Kurki MI, Marttila J, Mäkinen PI, Rostalski H, Hietanen T, Ngandu T, Lehtisalo J, Bellenguez C, Lambert JC, Haass C, Rinne J, Hakumäki J, Rauramaa T, Krüger J, Soininen H, Haapasalo A, Lichtenthaler SF, Leinonen V, Solje E, Hiltunen M. Mol Neurodegener. 2025 Apr 29;20(1):50. doi: 10.1186/s13024-025-00830-3.

Risk stratification beyond fibrosis in SLD: The case for lifestyle-responsive prognostic tools. Åberg F, Asteljoki JV, Luukkonen PK. J Hepatol. 2025 Aug;83(2):e91-e92. doi: 10.1016/j.jhep.2025.04.024. Epub 2025 Apr 22.

Nuclear envelope-associated lipid droplets are enriched in cholesteryl esters and increase during inflammatory signaling. Szkalisity Á, Vanharanta L, Saito H, Vörös C, Li S, Isomäki A, Tomberg T, Strachan C, Belevich I, Jokitalo E, Ikonen E. EMBO J. 2025 May;44(10):2774-2802. doi: 10.1038/s44318-025-00423-2. Epub 2025 Apr 7.

Evidence-based criteria for identifying at-risk individuals requiring liver disease screening. Åberg F, Männistö V, Asteljoki J, Salomaa V, Jula A, Lundqvist A, Männistö S, Perola M, Luukkonen PK. Hepatol Commun. 2025 Mar 21;9(4):e0679. doi: 10.1097/HC9.0000000000000679. eCollection 2025 Apr 1.

Subtypes of MASLD confer distinct clinical trajectories. Luukkonen PK. J Hepatol. 2025 Jun;82(6):1138-1139. doi: 10.1016/j.jhep.2025.02.032. Epub 2025 Mar 17.

Metabolic dysfunction-associated steatotic liver disease in adults. Huang DQ, Wong VWS, Rinella ME, Boursier J, Lazarus JV, Yki-Järvinen H, Loomba R. Nat Rev Dis Primers. 2025 Mar 6;11(1):14. doi: 10.1038/s41572-025-00599-1.

Hidden metabolic effects of acetyl-CoA carboxylase inhibition. Luukkonen PK. J Hepatol. 2025 Mar;82(3):544-545. doi: 10.1016/j.jhep.2024.11.043. Epub 2024 Dec 16.

Function of PNPLA3 I148M-Lessons From In Vivo Studies in Humans. Yki-Järvinen H, Luukkonen PK. Liver Int. 2025 Apr;45(4):e70047. doi: 10.1111/liv.70047.

Circulating levels of miR-20b-5p are associated with survival in cardiogenic shock. Mäntylä T, Wang C, Hänninen M, Immonen K, Jäntti T, Lassus J, Tikkanen I, Pulkki K, Devaux Y, Harjola VP, Lakkisto P; CardShock Study Investigators. J Mol Cell Cardiol Plus. 2025 Jan 17;11:100284. doi: 10.1016/j.jmccpl.2025.100284. eCollection 2025 Mar.

Proteomic profiling reveals alterations in metabolic and cellular pathways in severe obesity and following metabolic bariatric surgery. Dadson P, Honka MJ, Suomi T, Haridas PAN, Rokka A, Palani S, Goltseva E, Wang N, Roivainen A, Salminen P, James P, Olkkonen VM, Elo LL, Nuutila P. Am J Physiol Endocrinol Metab. 2025 Mar 1;328(3):E311-E324. doi: 10.1152/ajpendo.00220.2024. Epub 2025 Jan 17.

Insight into the function of the Golgi membrane protein GOLM1 in cholangiocytes through interactomic analysis. Nagaraj M, Emmagouni SKG, Chaurasiya V, Li L, Nguyen VD, Keskitalo S, Varjosalo M, Zhou Y, Haridas PAN, Olkkonen VM. FEBS Lett. 2025 Feb 1. doi: 10.1002/1873-3468.70001. Online ahead of print.

The role of Nir2, a lipid-transfer protein, in regulating endothelial cell functions. Polianskyte-Prause Z, Arora A, Taskinen JH, Chaurasiya V, Keskitalo S, Tuhkala A, Hilska I, Varjosalo M, Olkkonen VM. Biochim Biophys Acta Mol Cell Res. 2025 Feb 25;1872(3):119926. doi: 10.1016/j.bbamcr.2025.119926. Online ahead of print.

Age at type 1 diabetes onset does not influence attained brain volume. Claesson TB, Mutter S, Putaala J, Salli E, Gordin D, Groop PH, Martola J, Thorn LM. BMC Endocr Disord. 2025 Feb 18;25(1):43. doi: 10.1186/s12902-025-01868-6.

A proteomic signature of healthspan. Kuo CL, Liu P, Drouard G, Vuoksimaa E, Kaprio J, Ollikainen M, Chen Z, Pilling LC, Atkins JL, Fortinsky RH, Kuchel GA, Diniz BS. medRxiv [Preprint]. 2025 Jan 28:2024.06.26.24309530. doi: 10.1101/2024.06.26.24309530.

Suboptimal dietary patterns are associated with accelerated biological aging in young adulthood: A study with twins. Ravi S, Kankaanpää A, Bogl LH, Heikkinen A, Pietiläinen KH, Kaprio J, Ollikainen M, Sillanpää E. Clin Nutr. 2025 Feb;45:10-21. doi: 10.1016/j.clnu.2024.12.018. Epub 2024 Dec 19.

Glycemic control in women with GDM: insights from a randomized controlled pilot trial on plant-based Nordic healthy diet versus moderately carbohydrate restricted diet. Markussen LT, Kivelä J, Lindström J, Ollikainen M, Kytö M, Heinonen S, Koivusalo S, Meinilä J. BMC Nutr. 2025 Jan 16;11(1):12. doi: 10.1186/s40795-024-00988-x.

Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits. Brotman SM, El-Sayed Moustafa JS, Guan L, Broadaway KA, Wang D, Jackson AU, Welch R, Currin KW, Tomlinson M, Vadlamudi S, Stringham HM, Roberts AL, Lakka TA, Oravilahti A, Fernandes Silva L, Narisu N, Erdos MR, Yan T, Bonnycastle LL, Raulerson CK, Raza Y, Yan X, Parker SCJ, Kuusisto J, Pajukanta P, Tuomilehto J, Collins FS, Boehnke M, Love MI, Koistinen HA, Laakso M, Mohlke KL, Small KS, Scott LJ. Nat Genet. 2025 Jan;57(1):180-192. doi: 10.1038/s41588-024-01982-6. Epub 2025 Jan 2.

LAPTM4B counteracts ferroptosis via suppressing the ubiquitin-proteasome degradation of SLC7A11 in non-small cell lung cancer. Yan R, Liu D, Guo H, Liu M, Lv D, Björkblom B, Wu M, Yu H, Leng H, Lu B, Li Y, Gao M, Blom T, Zhou K. Cell Death Dis. 2024 Jun 20;15(6):436. doi: 10.1038/s41419-024-06836-x.

Transcriptomic and Metabolomic Analyses in Monozygotic and Dizygotic Twins. Hubers N, Drouard G, Jansen R, Pool R, Hottenga JJ, Ollikainen M, Wang X, Willemsen G, Kaprio J, Boomsma DI, van Dongen J. Am J Med Genet A. 2024 Dec 16:e63971. doi: 10.1002/ajmg.a.63971. Online ahead of print.

SMIM1 absence is associated with reduced energy expenditure and excess weight. Stefanucci L, Moslemi C, Tomé AR, Virtue S, Bidault G, Gleadall NS, Watson LPE, Kwa JE, Burden F, Farrow S; DBDS Genetic Consortium; Chen J; MAGIC; Võsa U, Burling K, Walker L, Ord J, Barker P, Warner J, Frary A, Renhstrom K, Ashford SE, Piper J, Biggs G, Erber WN, Hoffman GJ, Schoenmakers N, Erikstrup C, Rieneck K, Dziegiel MH, Ullum H, Azzu V, Vacca M, Aparicio HJ, Hui Q, Cho K, Sun YV, Wilson PW, Bayraktar OA, Vidal-Puig A, Ostrowski SR, Astle WJ, Olsson ML, Storry JR, Pedersen OB, Ouwehand WH, Chatterjee K, Vuckovic D, Frontini M. Med. 2024 Sep 13;5(9):1083-1095.e6. doi: 10.1016/j.medj.2024.05.015. Epub 2024 Jun 20.

Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease. Raverdy V, Tavaglione F, Chatelain E, Lassailly G, De Vincentis A, Vespasiani-Gentilucci U, Qadri SF, Caiazzo R, Verkindt H, Saponaro C, Kerr-Conte J, Baud G, Marciniak C, Chetboun M, Oukhouya-Daoud N, Blanck S, Vandel J, Olsson L, Chakaroun R, Gnemmi V, Leteurtre E, Lefebvre P, Haas JT, Yki-Järvinen H, Francque S, Staels B, Le Roux CW, Tremaroli V, Mathurin P, Marot G, Romeo S, Pattou F. Nat Med. 2024 Dec;30(12):3624-3633. doi: 10.1038/s41591-024-03283-1. Epub 2024 Dec 9.

Hidden metabolic effects of acetyl-CoA carboxylase inhibition. Luukkonen PK. J Hepatol. 2024 Dec 16:S0168-8278(24)02745-4. doi: 10.1016/j.jhep.2024.11.043. Online ahead of print.

The Value of Repeat 5-HIAA Measurements as a Predictor of Carcinoid Heart Disease: A Prospective 5-Year Follow-Up Study in Patients with Small Intestinal Neuroendocrine Tumors. Kostiainen I, Simonen P, Aaltonen K, Lindén R, Karppinen N, Gordin D, Rapola J, Schalin-Jäntti C, Matikainen N. Cancers (Basel). 2024 Nov 21;16(23):3896. doi: 10.3390/cancers16233896.

A metabolome-derived score predicts metabolic dysfunction-associated steatohepatitis and mortality from liver disease. Huang Q, Qadri SF, Bian H, Yi X, Lin C, Yang X, Zhu X, Lin H, Yan H, Chang X, Sun X, Ma S, Wu Q, Zeng H, Hu X, Zheng Y, Yki-Järvinen H, Gao X, Tang H, Xia M. J Hepatol. 2024 Oct 16:S0168-8278(24)02636-9. doi: 10.1016/j.jhep.2024.10.015. Online ahead of print.

Pre-diagnosis blood DNA methylation profiling of twin pairs discordant for breast cancer points to the importance of environmental risk factors. Bode HF, He L, Hjelmborg JVB, Kaprio J, Ollikainen M. Clin Epigenetics. 2024 Nov 18;16(1):160. doi: 10.1186/s13148-024-01767-y.

PCSK9 Antibodies Treatment Specifically Enhances the Macrophage-specific Reverse Cholesterol Transport Pathway in Heterozygous Familial Hypercholesterolemia. Borràs C, Canyelles M, Girona J, Ibarretxe D, Santos D, Revilla G, Llorente-Cortes V, Rotllan N, Kovanen PT, Jauhiainen M, Lee-Rueckert M, Masana L, Arrieta F, Martínez-Botas J, Gómez-Coronado D, Ribalta J, Tondo M, Blanco-Vaca F, Escolà-Gil JC. JACC Basic Transl Sci. 2024 Aug 28;9(10):1195-1210. doi: 10.1016/j.jacbts.2024.06.008. eCollection 2024 Oct.

Circulating hsa-miR-320a and its regulatory network in type 1 diabetes mellitus. Nizam R, Malik MZ, Jacob S, Alsmadi O, Koistinen HA, Tuomilehto J, Alkandari H, Al-Mulla F, Thanaraj TA. Front Immunol. 2024 Oct 11;15:1376416. doi: 10.3389/fimmu.2024.1376416. eCollection 2024.

Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations. Salo V, Määttä J, Sliz E; FinnGen; Reimann E, Mägi R; Estonian Biobank Research Team; Reis K, Elhanas AG, Reigo A, Palta P, Esko T, Karppinen J, Kettunen J. Nat Commun. 2024 Nov 7;15(1):9424. doi: 10.1038/s41467-024-53467-z.

A sham-controlled randomised pilot trial on baroreflex activation therapy in patients with resistant hypertension: What will the future hold? Gordin D, Simonsen R, Tikkanen I. Blood Press. 2024 Dec;33(1):2417887. doi: 10.1080/08037051.2024.2417887. Epub 2024 Oct 23.

The role of dietary modification in the prevention and management of metabolic dysfunction-associated fatty liver disease: An international multidisciplinary expert consensus. Zeng XF, Varady KA, Wang XD, Targher G, Byrne CD, Tayyem R, Latella G, Bergheim I, Valenzuela R, George J, Newberry C, Zheng JS, George ES, Spearman CW, Kontogianni MD, Ristic-Medic D, Peres WAF, Depboylu GY, Yang W, Chen X, Rosqvist F, Mantzoros CS, Valenti L, Yki-Järvinen H, Mosca A, Sookoian S, Misra A, Yilmaz Y, Kim W, Fouad Y, Sebastiani G, Wong VW, Åberg F, Wong YJ, Zhang P, Bermúdez-Silva FJ, Ni Y, Lupsor-Platon M, Chan WK, Méndez-Sánchez N, de Knegt RJ, Alam S, Treeprasertsuk S, Wang L, Du M, Zhang T, Yu ML, Zhang H, Qi X, Liu X, Pinyopornpanish K, Fan YC, Niu K, Jimenez-Chillaron JC, Zheng MH. Metabolism. 2024 Dec;161:156028. doi: 10.1016/j.metabol.2024.156028. Epub 2024 Sep 11.

Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles. Drouard G, Wang Z, Heikkinen A, Foraster M, Julvez J, Kanninen KM, van Kamp I, Pirinen M, Ollikainen M, Kaprio J. Sci Rep. 2024 Sep 11;14(1):21261. doi: 10.1038/s41598-024-72354-7.

A novel long non-coding RNA connects obesity to impaired adipocyte function. Lluch A, Latorre J, Oliveras-Cañellas N, Fernández-Sánchez A, Moreno-Navarrete JM, Castells-Nobau A, Comas F, Buxò M, Rodríguez-Hermosa JI, Ballester M, Espadas I, Martin-Montalvo A, Zhang B, Zhou Y, Burkhardt R, Höring M, Liebisch G, Castellanos-Rubio A, Santin I, Kar A, Laakso M, Pajukanta P, Olkkonen VM, Fernández-Real JM, Ortega FJ. Mol Metab. 2024 Oct 1:102040. doi: 10.1016/j.molmet.2024.102040. Online ahead of print.

CNPY2 protects against ER stress and is expressed by corticostriatal neurons together with CTIP2 in a mouse model of Huntington’s disease. Scordino M, Stepanova P, Srinivasan V, Pham DD, Eriksson O, Lalowski M, Mudò G, Di Liberto V, Korhonen L, Voutilainen MH, Lindholm D. Front Mol Neurosci. 2024 Sep 18;17:1473058. doi: 10.3389/fnmol.2024.1473058. eCollection 2024.

Cholesterol binding to VCAM-1 promotes vascular inflammation. Kennelly JP, Xiao X, Gao Y, Kim S, Hong SG, Villanueva M, Ferrari A, Vanharanta L, Nguyen A, Nagari RT, Burton NR, Tol MJ, Becker AP, Lee MJ, Ikonen E, Backus KM, Mack JJ, Tontonoz P. bioRxiv [Preprint]. 2024 Sep 18:2024.09.17.613543. doi: 10.1101/2024.09.17.613543.

Altered oxidant and antioxidant levels are associated with vascular stiffness and diabetic kidney disease in type 1 diabetes after exposure to acute and chronic hyperglycemia. Adeshara K, Di Marco E, Bordino M, Gordin D, Bernardi L, Cooper ME, Groop PH; FinnDiane Study Group. Cardiovasc Diabetol. 2024 Sep 28;23(1):350. doi: 10.1186/s12933-024-02427-4.

Genetic susceptibility to acute viral bronchiolitis. Pasanen A, Karjalainen MK, Korppi M, Hallman M, Rämet M; Research Project FinnGen. J Infect Dis. 2024 Sep 20:jiae467. doi: 10.1093/infdis/jiae467. Online ahead of print.

Protein Phosphatase 1 Regulatory Subunit 3 Beta rs4240624 Genotype Is Associated With Gallstones and With Significant Changes in Bile Lipidome. Männistö VT, Kaminska D, Haal S, Asteljoki J, Luukkonen PK, Käkelä P, Tavaglione F, van Weeghel M, Neuvonen M, Niemi M, Romeo S, Nieuwdorp M, Pihlajamäki J, Groen AK. Gastro Hep Adv. 2024 Mar 12;3(5):594-601. doi: 10.1016/j.gastha.2024.03.005. eCollection 2024.

Cardiac Structure and Function in 8- to 12-Year-Old Children Following In-Utero Exposure to Preeclampsia (FINNCARE Study). Renlund-Vikström M, Jääskeläinen TJ, Kivelä A, Heinonen S, Laivuori H, Sarkola T. J Am Heart Assoc. 2024 Aug 6;13(15):e034494. doi: 10.1161/JAHA.124.034494. Epub 2024 Jul 16.

A Bivariate Twin Study of Lifetime cannabis Initiation and Lifetime Regular Tobacco Smoking Across Three Different Countries. Zellers S, van Dongen J, Maes HHM, Ollikainen M, Fang F, Vrieze S, Kaprio J, Boomsma DI. Behav Genet. 2024 Sep;54(5):375-385. doi: 10.1007/s10519-024-10190-1. Epub 2024 Jul 30.

Kupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult. Di Nunzio G, Hellberg S, Zhang Y, Ahmed O, Wang J, Zhang X, Björck HM, Chizh V, Schipper R, Aulin H, Francis R, Fagerberg L, Gisterå A, Metso J, Manfé V, Franco-Cereceda A, Eriksson P, Jauhiainen M, Hagberg CE, Olofsson PS, Malin SG. Nat Cardiovasc Res. 2024 Mar;3(3):356-371.

Fluid bolus increases plasma hyaluronan concentration compared to follow-up strategy without a bolus in oliguric intensive care unit patients. Serlo M, Inkinen N, Lakkisto P, Valkonen M, Pulkkinen A, Selander T, Pettilä V, Vaara ST. Sci Rep. 2024 Sep 6;14(1):20808. doi: 10.1038/s41598-024-71670-2.

Circulating microRNAs targeting coagulation and fibrinolysis in patients with severe COVID-19. Helin TA, Lemponen M, Immonen K, Lakkisto P, Joutsi-Korhonen L. Thromb J. 2024 Sep 5;22(1):80. doi: 10.1186/s12959-024-00649-w.

Guidelines for mitochondrial RNA analysis. Jusic A, Erpapazoglou Z, Dalgaard LT, Lakkisto P, de Gonzalo-Calvo D, Benczik B, Ágg B, Ferdinandy P, Fiedorowicz K, Schroen B, Lazou A, Devaux Y; EU-CardioRNA COST Action CA17129; AtheroNET COST Action CA21153. Mol Ther Nucleic Acids. 2024 Jun 26;35(3):102262. doi: 10.1016/j.omtn.2024.102262. eCollection 2024 Sep 10.

Soybean oil-based HFD induces gut dysbiosis that leads to steatosis, hepatic inflammation and insulin resistance in mice. Jacob T, Sindhu S, Hasan A, Malik MZ, Arefanian H, Al-Rashed F, Nizam R, Kochumon S, Thomas R, Bahman F, Shenouda S, Wilson A, Akther N, Al-Roub A, Abukhalaf N, Albeloushi S, Abu-Farha M, Al Madhoun A, Alzaid F, Thanaraj TA, Koistinen HA, Tuomilehto J, Al-Mulla F, Ahmad R. Front Microbiol. 2024 Aug 6;15:1407258. doi: 10.3389/fmicb.2024.1407258. eCollection 2024.

Analysis of early-pregnancy metabolome in early- and late-onset gestational diabetes reveals distinct associations with maternal overweight. Masalin S, Klåvus A, Rönö K, Koistinen HA, Koistinen V, Kärkkäinen O, Jääskeläinen TJ, Klemetti MM. Diabetologia. 2024 Jul 31. doi: 10.1007/s00125-024-06237-x. Online ahead of print.

Gut Dysbiosis Shaped by Cocoa Butter-Based Sucrose-Free HFD Leads to Steatohepatitis, and Insulin Resistance in Mice. Kochumon S, Malik MZ, Sindhu S, Arefanian H, Jacob T, Bahman F, Nizam R, Hasan A, Thomas R, Al-Rashed F, Shenouda S, Wilson A, Albeloushi S, Almansour N, Alhamar G, Al Madhoun A, Alzaid F, Thanaraj TA, Koistinen HA, Tuomilehto J, Al-Mulla F, Ahmad R. Nutrients. 2024 Jun 18;16(12):1929. doi: 10.3390/nu16121929.