Dissertations from the Minerva Institute
2024
Vignesh Srinivasan: Novel roles of the protein deubiquitinase USP14 in proteostasis regulation and cell stress responses. October 11, 2024
Juuso Taskinen: The role of endoplasmic reticulum membrane contact sites in human endothelial cells. October 4, 2024.
Taru Knuutinen: The importance of calcium channels in thyroid cancer. September 27, 2024.
Michelle Renlund-Vikström: Cardiovascular health in preadolescent children following in-utero exposure to pre-eclampsia. June 7, 2024.
Suneeta Narumanchi: Septin7b and let-7c modulate cardiac function and regeneration in zebrafish. June 5, 2024.
2023
Juho Pirhonen: Mechanisms of lipid deposition: Application of novel omics techniques, tissue imaging methods, and their synergistic deployment in lipid research. September 29, 2023.
Pushpa Khanal: Molecular regulation of the dendritic spine initiation. August 11, 2023.
Selina Mäkinen: Send in the signals: Studies on the mechanism of insulin resistance in human skeletal muscle. February 4, 2023.
2022
Mari Lahelma: Lifestyle factors and lipid metabolism in non-alcoholic fatty liver disease, the metabolic syndrome, and atherosclerotic cardiovascular disease. December 16, 2022.
Maria Ahonen Mehmeti: Mechanisms of adipocyte dysfunction in metabolic disease and cancer. December 9, 2022.
2021
Kien Dang: Diagnostic and prognostic role of expressed KRAS and BRAF mutations in MAPK/ERK-driven cancers. June 21, 2021.
Annika Koponen: ORP2 – a lipid-binding protein controlling cellular cholesterol transport and signal transduction. April 1, 2021.
Kecheng Zhou: Crosstalk between sphingolipid metabolism and nutrient signaling: Studies on LAPTM4B. March 4, 2021.
2020
Hanna Ruhanen: Hepatic lipid metabolism in cardiometabolic diseases – protective and adverse effects of genetic variants. October 13, 2020.
Dan Pham Duc: Novel roles of p75 neurotrophin receptor in Low-density lipoprotein receptor regulation and lipid signaling. June 4, 2020.
Veijo Salo: Lipogenic subdomains of the ER: The role of seipin. April 17, 2020.
Amr Abouelezz: The structure and dynamics of the actin cytoskeleton in the axon initial segment. February 28, 2020.
2019
Iryna Hlushchenko: Actin regulation in dendritic spines: From synaptic plasticity to animal behavior and neurodevelopmental disorders. August 16, 2019.
2018
Panu Luukkonen: Heterogeneity of non-alcoholic fatty liver disease – Genetic and nutritional modulation of hepatic lipid metabolism. September 7, 2018.
Henriikka Kentala: ORP2 – A sterol sensor controlling hepatocellular bioenergetics and actin cytoskeletal functions. August 18, 2018
Raghavendra Mysore: Novel molecular regulators of adipose tissue metabolism. May 18, 2018.
Anna Tikka: Characterization of ANGPTL3 deficiency and molecular mechanisms of ANGPTL3 deficiency-induced hypolipodemia. January 19, 2018.
Susanna Lallukka: Non-alcoholic fatty liver disease: The role of insulin resistance, inflammation and the PNPLA3 I148M variant. January 13, 2018.
2017
Jenni Hyysalo: Prevalence and Genetics of Non-Alcoholic Fatty Liver Disease. December 16, 2017.
Elina Isokuortti: Non-alcoholic fatty liver disease – Studies on pathogenesis and diagnosis. October 28, 2017.
Boris Vassilev: Studies on proteins influencing cancer progression and regulating endocytic lipid trafficking. April 28, 2017.
2016
Johanna Mäkelä: Neuroprotective effects of PGC-1α activators in dopaminergic neurons. May 20, 2016.
2015
Veronica Kalhori: Sphingosine-1-phosphate-evoked invasion of follicular thyroid cancer cells: Evidence for the involvement of HIF-1a, MMP2 and MMP9. September 11, 2015.
Tho Huu Ho: Development of amplification-based technologies for enrichment of nucleic acids with difficult sequences or low-abundance point mutations. February 13, 2015.
2014
Alise Hyrskyluoto: Endoplasmic reticulum stress, regulation of autophagy and ubiquitin-proteosome system in cellular models of Huntington’s Disease. September 12, 2014.
Leena Juurinen: Insulin therapy in type 2 diabetes – Initiation, impact on liver fat, role of combination therapy with glitazones or glinides. May 16, 2014.
Jere Paavola: Aberrant intracellular calcium cycling in the heart – Mechanistic insights into catecholaminergic polymorphic ventricular tachycardia and heart failure. March 28, 2014.
2013
Anders Eriksson-Palojärvi: Neurohumoral responce and pathophysiologic changes during progresson of mitral reurgitation in the Cavalier King Charles spaniel. November 29, 2013.
Wei Wang: Studies on the transcriptional and enzymatic control of steroid metabolism: Regulation by lysosomal acid lipase, 24-dehydrocholesterol reductace, and amyloid precursor protein. November 28, 2013.
Raili Koivuniemi: Regulation of neural progenitor cell proliferation and fate by proteolytic pathways and inflammatory signals in the brain. September 6, 2013.
You Zhou: Oxysterol binding protein homologues: Novel functions in intracellular transport and adipogenesis. January 25, 2013.
2012
Noora Putkonen: Organelle specific mechanism of neuronal cell death. October 26, 2012.
Terhi Vihervaara: The role of oxysterol binding proteins in macrophages. October 5, 2012.
Paulina Skrobuk: Glucose and lipid metabolism in human skeletal muscle. September 7, 2012.
2011
Ksenia Sevastianova: Combination antiretroviral therapy-associated lipodystrophy: insights into pathogenesis and treatment. November 25, 2011.
2010
Päivi Lakkisto: Heme oxygenase-1 in cardiovascular diseases. December 17, 2010.
Minna Kairisalo: Oxidative stress and XIAP signalling in neuronal cells. October 15, 2010.
Sami Reijonen: Endoplasmic reticulum stress and cell death mechanisms in the cell model of Huntington’s disease. October 8, 2010.
Nina Bergelin: Interactions between sphingosine 1-phosphate and vascular endothelial growth factor signaling in thyroid carcinoma cells. September 17, 2010.
Tero Viitanen: GABAa reseptor mediated signalling in the brain: inhibition, shunting and excitation. June 23, 2010.
Janne Makkonen: Adipose tissue inflammation, liver fat and insulin resistance in humans. June 18, 2010.
2008
Anna Kotronen: Liver fat in the metabolic syndrome and type 2 diabetes.
2007
Cia Ramström: Ceramides and DAG as regulators of potassium channel function.
2006
Tomas Blom: Sphingolipid-mediated regulation of cellular calcium signaling and survival.
2005
Mirja Tiikkainen: Effects of weight loss, rosiglitazone and metformin on liver fat content, insulin resistance and gene expression in adipose tissue”
2004
Marjo Tamminen: Vascular and Platelet Function in Insulin Resistance
Esa Leppänen: Experimental basis for standardization of blood specimen collection. (started in Minerva but was completed in Jyväskylä)
2003
Elena Korsheninnikova: Molecular mechanisms of insulin resistance in human skeletal muscle and lipodystrophic adipose tissue. July 4, 2003.
Robert Bergholm: Effects of weight loss, physical training and anti-inflammatory therapy on endothelial function in vivo.
Jussi Sutinen: Pathogenesis and treatment of lipodystrophy in HIV-infected patients receiving highly active antiretroviral therapy.
2002
Nina Uhlenius: Angiotensin II and nitric oxide in chronic experimental nephritis.
2001
Jukka Westerbacka: Insulin action on large artery stiffness in normal and insulin resistant subjects.
Satu Vehkavaara: Identification and treatment of endothelial dysfunction and cardiovascular risk markers in disorders of glucose metabolism and in postmenopausal women.
2000
Benoît Dugué: Variabilité Biologique. Influence des facteurs preanalytiques in vivo (stress physique, stress psychologique, chronobiologie) sur les résultants d’analyses de marqueurs biologiques sanguins et cellulaires.
1999
Markus Sundblom: Neuropeptide FF in human blood and cerebrospinal fluid.
1998
Leena Karhapää: Effects of caffeine and thimerosal on the regulation of intracellular calsium concentration in GH4C1 rat pituitary cells.
1997
Marja-Leena Sirviö: Endothelin-1; cardiopulmonal expression, metabolism and regulation of atrial natriuretic peptide release.
1995
Antti Virkamäki: Mechanism and causes of abnormal carbohydrate metabolism during experimental and natural infections.
1994
Outi Saijonmaa: Endothelin-1: Plasma levels in cold pressor test and regulation in endothelial cells.
Karri Helin: Neutral endopeptidase inhibition in experimental heart failure.
1991
Sari Tikanoja: Free thyroid hormones in serum: performance of different assay methodologies in thyroid diseases and non-thyroidal illnesses.
1989
Per-Henrik Groop: The relationship between gastric inhibitory polypeptide (GIP) and beta-cell function in man.
Tuula Tikkanen: Atrial natriuretic peptide in experimental heart failure.
Kaj Metsärinne: Renin substrate in human plasma and amniotic fluid.
1987
Kid Törnquist: 1,25-dihydroxyvitamin D3 and the secretion of thyrotropin and prolactin from the rat pituitary gland.
Katarina Rosenlöf: Erythropoietin: receptor and comparison with renin substrate.
1986
Virpi Oksanen: Neurosarcoidosis: A clinical, laboratory and neuroradiological study.
Jean-Louis Guéant:
1984
Markku M. Nieminen: Renin-Aldosterone axis in man following ingestion of ethanol.
Christel Lamberg-Allardt: Serum 25-hydroxy-vitamin D concentration and vitamin D intake.
Terje Forslund: Induction of rat angiotensin converting enzyme by captopril and enalapril.
1983
Ilkka Immonen: Factors affecting human plasma renin substrate concentration with emphasis on estrogens and pregnancy.
1982
Jaakko Linkola: Strain differences in water and electrolyte metabolism between alcohol preferring (AA) and alcohol avoiding (ANA) rats.
Tom Petterson: Pleural effusions in infectious, neoplastic and connective tissue diseases. A study of cellular and immunological reactions with emphasis on the role of T and B lymphoytes.
1981
Ilkka Kouvonen: Structure of the porcine intestinal intrinsic factor (IF) receptor.
Ilkka Tikkanen: Hypertensive effect of autoimmune nephritis in DOCA-NaCl-treated and in spontaneously hypertensive rats.
Georg Borgström: Clinical implications of chromosome aberrations in hematologic neoplasia.
1980
Carola Grönhagen-Riska: Angiotensin converting enzyme and sarcoidosis.
Fredrika Pekonen: The interaction of thyrotropin with its receptors.
1978
Thomas Tötterman: Thyroid-infiltrating immunocompetent cells in human autoimmune thyroid disease.
George Marcoullis: Soluble and membrane-bound proteins involved in vitamin B12 transport.
Pertti Soveri: Renin in human pregnancy and during oral contraception.
1975
Gustav Wägar: Effect of TSH and cyclic adenosine 3´, 5´-monophosphate on thyroidal protein synthesis.
Jim Schröder: Passage of blood cells between foetus and mother.
1974
Ariel Gordin: Thyrotrophin in human serum; A methodological and clinical study in diseases of the thyroid gland.
Ulf-Håkan Stenman: Studies on cobalophilin. Vitamin B12-binding proteins of R-type.
Ritva-Kajsa Selander: Kromosomala makromolekylers effekt på vissa akridinderivats absorption och fluorescens.
1973
Aldur Eriksson: Human twinning in and around the Åland Islands.
1972
Jorma Mäenpää: Hypothyroidism and autoimmune thyroiditis in childhood.
Risto Kala: Venous plasma angiotensin II in man. Diurnal variation and response to various postural stimuli and exercise.
1971
Johan Wennström: Effect of ionizing radiation on the chromosomes in meiotic and mitotic cells.
Frej Fyhrquist: Radioimmunoassay of plasma angiotensin II in patients with hypertension, in renal transplant recipients, and in anephric patients.
1970
Johan Edgren: Effect of cysteine on chromosome aberrations induced by radiation of human lymphocytes in vitro.
1969
Teddy Weber: Isolation and characterization of a lymphocyte-stimulating leucoagglutinin from red kidney beans. (Phaseolus vulgaris).
1968
Rolf Nordman: Endemic goitre in Finland in the light of thyroids of newborn in 1962-1965.
Kristian Liewendahl: Iodochloroxyquinoline and the thyroid gland. Metabolism of iodochloroxyquinoline iodine and its effect on the thyroid iodine metabolism in rats.
1964
Kaj Simons: Vitamin B12 binders in human body fluids and blood cells.
1962
Albert de la Chapelle: Cytogenetical and clinical observations in female gonadal dysgenesis.