{"id":690,"date":"2026-10-05T07:06:17","date_gmt":"2026-10-05T07:06:17","guid":{"rendered":"https:\/\/minervainstitute.fi\/?post_type=research-groups&p=690"},"modified":"2026-10-08T14:11:08","modified_gmt":"2026-10-08T14:11:08","slug":"hjart-och-karlforskning","status":"publish","type":"research-groups","link":"https:\/\/minervainstitute.fi\/sv\/forskningsgrupper\/hjart-och-karlforskning\/","title":{"rendered":"Hj\u00e4rt- och k\u00e4rlforskning"},"content":{"rendered":"
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Gruppledare<\/h3>
\r\nP\u00e4ivi Lakkisto, MD, docent
\r\npaivi.lakkisto@helsinki.fi
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Gruppmedlemmar<\/h3>
\r\nIlkka Tikkanen, MD, professor
\r\nMika Laine, MD
\r\nChunguang Wang, MD
\r\nJere Paavola, MD
\r\nHong Wang, PhD
\r\nSuneeta Narumanchi, PhD
\r\nMikko H\u00e4nninen, ML
\r\nKarri Kalervo, ML
\r\nTuomas M\u00e4ntyl\u00e4, ML
\r\nHeli Segersv\u00e4rd, ML
\r\nIan H\u00e4gerstr\u00f6m, medicinstudent
\r\nKatariina Immonen, NaK, forskningsassistent
\r\nSanni Perttunen, NaK, forskningsassistent<\/p>\n <\/div>\n <\/div>\n
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Utvalda publikationer<\/h3>\n

Lakkisto P, Dalgaard LT, Belmonte T, Pinto-Sietsma SJ, Devaux Y, De Gonzalo-Calvo D. Development of circulating microRNA-based biomarkers for medical-decision making: a friendly reminder of what should NOT be done. Crit Rev Clin Lab Sci 2023, 60:141-152. doi: 10.1080\/10408363.2022.2128030<\/p>\n

Wang H, Segersv\u00e4rd H, Siren J, Perttunen S, Immonen K, Kosonen R, Chen YC, Tolva J, Laivuori M, M\u00e4yr\u00e4np\u00e4\u00e4 MI, Kovanen PT, Sinisalo J, Laine M, Tikkanen I, Lakkisto P. Tankyrase Inhibition Attenuates Cardiac Dilatation and Dysfunction in Ischemic Heart Failure. Int J Mol Sci. 2022; 23:10059. doi: 10.3390\/ijms231710059<\/p>\n

Wang C, Taskinen J, Segersv\u00e4rd H, Immonen K, Kosonen R, Tolva JM, M\u00e4yr\u00e4np\u00e4\u00e4 MI, Kovanen PT, Olkkonen VM, Sinisalo J, Laine M, Tikkanen I, Lakkisto P. Alterations of cardiac protein kinases in cyclic nucleotide-dependent signaling pathways in human ischemic heart failure. Front Cardiovasc Med 2022, 9:919355. doi: 10.3389\/fcvm.2022.919355<\/p>\n

Narumanchi S, Wang H, Perttunen S, Tikkanen I, Lakkisto P, Paavola J. Zebrafish heart failure models. Front Cell Dev Biol 2021; 9:662583. doi: 10.3389\/fcell.2021.662583<\/p>\n

H\u00e4nninen M, J\u00e4ntti T, Tolppanen H, Segersv\u00e4rd H, Tarvasm\u00e4ki T, Lassus J, Vausort M, Devaux Y, Sionis A, Tikkanen I, Harjola V-P, Lakkisto P. Association of miR-21-5p, miR-122-5p and miR-320a-3p with 90-day mortality in cardiogenic shock. Int J Mol Sci 2020; 21:E7925; doi:10.3390\/ijms21217925<\/p>\n

Paavola J, Alakoski T, Ulvila J, Kilpi\u00f6 T, Siren J, Perttunen S, Narumanchi S, Wang H, Lin R, Porvari K, Junttila J, Huikuri H, Immonen K, Lakkisto P, Magga J, Tikkanen I, Kerkel\u00e4 R. Vezf1 regulates cardiac structure and contractile function. EBioMedicine 2020; 51:102608. Doi: 10.1016\/j.ebiom.2019.102608<\/p>\n

J\u00e4ntti T, Segersv\u00e4rd H, Tarvasm\u00e4ki T, Lassus J, Devaux Y, Vausort M, Pulkki K, Sionis A, Bayes-Genis A, Tikkanen I, Lakkisto P, Harjola V-P. Circulating levels of microRNA 423-5p are associated with 90-day mortality in cardiogenic shock. ESC Heart failure, 2019; 6: 98-102<\/p>\n

Kaartokallio T, Utge S, Klemetti MM, Paananen J, Pulkki K, Romppanen J, Tikkanen I, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Lakkisto P, Laivuori H. Fetal microsatellite in the heme oxygenase 1 promoter is associated with severe and early-onset preeclampsia. Hypertension 2018; 71: 95-102.<\/p>\n

Segersv\u00e4rd H, Lakkisto P, H\u00e4nninen M, Forsten H, Siren J, Immonen K, Kosonen R, Sarparanta M, Laine M, Tikkanen I. Carbon monoxide releasing molecule improves structural and functional cardiac recovery after myocardial injury. Eur J Pharmacol 2018; 818: 57-66.<\/p>\n

Dash SN, Narumanchi S, Paavola J, Perttunen S, Wang H, Lakkisto P, Tikkanen I, Lehtonen S. Sept7b is required for the subcellular organization of cardiomyocytes and cardiac function in zebrafish. Am J Physiol Heart Circ Physiol 2017; 312: H1085-H1095.<\/p>\n

Finansi\u00e4rer av forskningen<\/h3>\n

Aarne Koskelon S\u00e4\u00e4ti\u00f6
\nFinska Vetenskaps-Societeten
\nStiftelsen f\u00f6r hj\u00e4rtforskning
\nLaboratoriol\u00e4\u00e4ketieteen edist\u00e4miss\u00e4\u00e4ti\u00f6
\nSuomen Kliinisen Kemian yhdistys
\nFinska L\u00e4kares\u00e4llskapet
\nMedicinska Underst\u00f6dsf\u00f6reningen Liv och H\u00e4lsa r.f.
\nP\u00e4ivikki och Sakari Sohlbergs stiftelse
\nHUS forskningsfinansiering (statlig finansiering f\u00f6r p\u00e5 universitetsniv\u00e5)<\/p>\n

F\u00f6lj<\/h3>\n

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