{"id":688,"date":"2026-10-05T07:12:58","date_gmt":"2026-10-05T07:12:58","guid":{"rendered":"https:\/\/minervainstitute.fi\/?post_type=research-groups&p=688"},"modified":"2026-10-08T13:44:11","modified_gmt":"2026-10-08T13:44:11","slug":"epigenomik-av-komplexa-egenskaper","status":"publish","type":"research-groups","link":"https:\/\/minervainstitute.fi\/sv\/forskningsgrupper\/epigenomik-av-komplexa-egenskaper\/","title":{"rendered":"Epigenomik av komplexa egenskaper"},"content":{"rendered":"
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Gruppledare<\/h3>
\r\nMiina Ollikainen, FD, docent
\r\nmiina.ollikainen@helsinki.fi
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Gruppmedlemmar<\/h3>
\r\nKrista Kokki, FD
\r\nTianyu Zhu, PhD
\r\nHannes Bode, MSc
\r\nAino Heikkinen, FM
\r\nMikaela Hukkanen, FM
\r\nAnna Kankanp\u00e4\u00e4, FM
\r\nTeodora Farago, BSc
\r\nPekka Heiskanen, NaK
\r\nMia Urjansson, forskningssjuksj\u00f6terska<\/p>\n <\/div>\n <\/div>\n
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Utvalda publikationer<\/h3>\n

Sehovic, E, Zellers SM, Youssef MK, Heikkinen A, Kaprio J, Ollikainen M. DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study. Clinical Epigenetics 2023, 15:181 https:\/\/doi.org\/10.1186\/s13148-023-01594-7<\/p>\n

F\u00f6hr T, Waller K, Viljanen A, Rantanen T, Kaprio J, Ollikainen M, and Sillanp\u00e4\u00e4 E. Mortality Associations With DNA Methylation-Based Biological Aging and Physical Functioning Measures Across a 20-Year Follow-up Period. Gerontol A Biol Sci Med Sci<\/em>, Advance Access publication January 22, 2023 https:\/\/doi.org\/10.1093\/gerona\/glad026<\/p>\n

Lapatto HAK, Kuusela M, Heikkinen A, Muniandy M, van der Kolk BW, Gopalakrishnan S, P\u00f6ll\u00e4nen N, Sandvik M, Schmidt MS, Heinonen S, Saari S, Kuula J, Hakkarainen A, Tampio J, Saarinen T, Taskinen M-R, Lundbom N, Groop P-H, Tiirola M, Katajisto P, Lehtonen M, Brenner C, Kaprio J, Pekkala S#, Ollikainen M#, Pietil\u00e4inen KHP* and Pirinen E*. Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation and gut microbiota in a twin study. Science Advances<\/em> 2023, 9; 2 DOI: 10.1126\/sciadv.add5163<\/p>\n

Kankaanp\u00e4\u00e4, A, Tolvanen, A, Heikkinen, A, Kaprio, J, Ollikainen, M, Sillanp\u00e4\u00e4, E The role of adolescent lifestyle habits in biological aging: A prospective twin study eLIFE 2022, Nov 8 https:\/\/doiorg\/107554\/eLife80729<\/p>\n

Marttila S, Tamminen H, Raji\u0107 S, Mishra PP, Lehtim\u00e4ki T, Raitakari O, K\u00e4h\u00f6nen M, Kananen L, Jylh\u00e4v\u00e4 J, H\u00e4gg S, Delerue T, Peters A, Waldenberger M, Kleber ME, M\u00e4rz W, Luoto R, Raitanen J, Sillanp\u00e4\u00e4 E, Laakkonen EK, Heikkinen A, Ollikainen M, Raitoharju E Methylation status of VTRNA2-1\/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues Epigenomics<\/em>, 2022, 14(18) https:\/\/doi.org\/10.2217\/epi-2022-0228<\/p>\n

Bode HF, Heikkinen A, Lundgren S, Kaprio J, Ollikainen M. Differences in DNA Methylation-Based Age Prediction Within Twin Pairs Discordant for Cancer. Twin Res Hum Genet<\/em> 2022 25;4-5 DOI: https:\/\/doi.org\/10.1017\/thg.2022.32<\/p>\n

Lundgren S, Kuitunen S, Pietil\u00e4inen K, Hurme M, K\u00e4h\u00f6nen M, Mannist\u00f6 S, Perola M, Lehtim\u00e4ki T, Raitakari O, Kaprio J, Ollikainen M. BMI is positively associated with accelerated epigenetic aging in twin pairs discordant for BMI Journal of Internal Medicine<\/em>, 2022, June 14 https:\/\/doiorg\/101111\/joim13528<\/p>\n

Drouard G, Ollikainen M, Mykk\u00e4nen J, Raitakari O, Lehtim\u00e4ki T, K\u00e4h\u00f6nen M, Mishra PP, Wang X, Kaprio J. Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values OMICS: A Journal of Integrative Biology, 26(3), 130-141 https:\/\/doiorg\/101089\/omi20210201<\/p>\n

Kankaanp\u00e4\u00e4 A, Tolvanen A, Saikkonen P, Heikkinen A, Laakkonen EK, Kaprio J, Ollikainen M, Sillanp\u00e4\u00e4 E. Do epigenetic clocks provide explanations for sex differences in lifespan? A cross-sectional twin study J Gerontol A Biol Sci Med Sci 2022 Sep 1;77(9):1898-1906 doi:101093\/gerona\/glab337<\/p>\n

van Dongen J, Gordon SD, McRae AF, Odintsova VV, Mbarek h, Breeze CE, Sugden K, Lundgren S, Castillo-Fernandez JE, Hannon E, Moffitt TE, Hagenbeek FA, van Beijsterveldt CEM, Hottenga JJ, Tsai PC, BIOS Consortium*, Genetics of DNA Methylation Consortium*, Min JL, Hemani G, Ehli EA, Paul F, Stern CD, Heijmans BT Slagboom PE, Daxinger L, van der Maarel SM, de Geus EJC, Willemsen G, Montgomery GW, Reversade B, Ollikainen M, Kaprio J, Spector TD, Bell JT, Mill J, Caspi A, Martin NG & Boomsma DI Identical twins carry a persistent epigenetic signature of early genome programming Nature Communications, 2021 12, 5618 https:\/\/doiorg\/101038\/s41467-021-25583-7<\/p>\n

Finansi\u00e4rer av forskningen<\/h3>\n

Eemil Aaltosen s\u00e4\u00e4ti\u00f6 (Mikaela Hukkanen)
\nSigrid Jus\u00e9lius Stiftelse
\nMedicinska Underst\u00f6dsf\u00f6reningen Liv och H\u00e4lsa r.f.
\nMinervastiftelsen
\nMSCA-ITN CANCERPREV (Hannes Bode)<\/p>\n

F\u00f6lj<\/h3>\n

Visit the group\u2019s website at theUniversity of Helsinki\/FIMM<\/a><\/p>\n\n <\/div>\n <\/section>\n\n <\/div>\n","protected":false},"template":"","class_list":["post-688","research-groups","type-research-groups","status-publish","hentry"],"acf":[],"yoast_head":"\nEpigenomik av komplexa egenskaper - Minervainstitutet<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/minervainstitute.fi\/sv\/forskningsgrupper\/epigenomik-av-komplexa-egenskaper\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Epigenomik av komplexa egenskaper - Minervainstitutet\" \/>\n<meta property=\"og:url\" content=\"https:\/\/minervainstitute.fi\/sv\/forskningsgrupper\/epigenomik-av-komplexa-egenskaper\/\" \/>\n<meta property=\"og:site_name\" content=\"Minervainstitutet\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-08T13:44:11+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/minervainstitute.fi\\\/sv\\\/forskningsgrupper\\\/epigenomik-av-komplexa-egenskaper\\\/\",\"url\":\"https:\\\/\\\/minervainstitute.fi\\\/sv\\\/forskningsgrupper\\\/epigenomik-av-komplexa-egenskaper\\\/\",\"name\":\"Epigenomik av komplexa egenskaper - 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