{"id":687,"date":"2026-10-05T07:16:53","date_gmt":"2026-10-05T07:16:53","guid":{"rendered":"https:\/\/minervainstitute.fi\/?post_type=research-groups&p=687"},"modified":"2026-10-08T13:41:07","modified_gmt":"2026-10-08T13:41:07","slug":"fettleversjukdom-och-diabetes","status":"publish","type":"research-groups","link":"https:\/\/minervainstitute.fi\/sv\/forskningsgrupper\/fettleversjukdom-och-diabetes\/","title":{"rendered":"Fettleversjukdom och diabetes"},"content":{"rendered":"
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Gruppledare<\/h3>
\r\nPanu Luukkonen, MD, docent
\r\npanu.luukkonen@helsinki.fi
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Gruppmedlemmar<\/h3>
\r\nHannele Yki-J\u00e4rvinen, MD, FRCP, professor
\r\nKimmo Porthan, MD
\r\nLaura Gran\u00f6, MD
\r\nSirkku J\u00e4ntti, FD
\r\nMari Lahelma, MD
\r\nP.A. Nidhina Haridas, PhD
\r\nNoora Ahlholm, ML
\r\nSami Qadri, ML
\r\nRiikka Sane, ML
\r\nMari Jokinen, FM
\r\nJuho Asteljoki, FK
\r\nNova Hongisto, FK
\r\nAnni Poikola, medicinstudent
\r\nDaniel Segercrantz, medicinstudent
\r\nAila Karioja-Kallio, torskningssjuksj\u00f6terska
\r\nP\u00e4ivi Ihamuotila, torskningssjuksj\u00f6terska<\/p>\n <\/div>\n <\/div>\n
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Utvalda publikationer<\/h3>\n

Luukkonen PK, Porthan K, Ahlholm N, Rosqvist F, Dufour S, Zhang XM, Lehtim\u00e4ki TE, Sepp\u00e4nen W, Orho-Melander M, Hodson L, Petersen KF, Shulman GI, Yki-J\u00e4rvinen H. The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans. Cell Metab. 2023:S1550-4131(23)00377-7.<\/p>\n

Luukkonen PK, Sakuma I, Gaspar RC, Mooring M, Nasiri A, Kahn M, Zhang XM, Zhang D, Sammalkorpi H, Penttil\u00e4 AK, Orho-Melander M, Arola J, Juuti A, Zhang X, Yimlamai D, Yki-J\u00e4rvinen H, Petersen KF, Shulman GI. Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis. Proc Natl Acad Sci U S A. 2023;120(4):e2217543120.<\/p>\n

Tamaki N*, Ahlholm N*, Luukkonen PK, Porthan K, Sharpton SR, Ajmera V, Kono Y, Dave S, Ahmed A, Sundaram V, Wilkinson MJ, Patton H, Gupta H, Cervantes V, Hernandez C, Lopez SJ, Loomba R, Baumgartner A, Richards L, Arkkila PE, Nemes K, Isoniemi H, Yki-J\u00e4rvinen H, Loomba R. Risk of advanced fibrosis in first-degree relatives of patients with nonalcoholic fatty liver disease. J Clin Invest. 2022;132(21):e162513.<\/p>\n

Luukkonen PK, Qadri S, Ahlholm N, Porthan K, M\u00e4nnist\u00f6 V, Sammalkorpi H, Penttil\u00e4 AK, Hakkarainen A, Lehtim\u00e4ki TE, Gaggini M, Gastaldelli A, Ala-Korpela M, Orho-Melander M, Arola J, Juuti A, Pihlajam\u00e4ki J, Hodson L, Yki-J\u00e4rvinen H. Distinct Contributions of Metabolic Dysfunction and Genetic Risk Factors in the Pathogenesis of Non-Alcoholic Fatty Liver Disease. J Hepatol. 2022;76(3):526-535.<\/p>\n

Yki-J\u00e4rvinen H, Luukkonen PK, Hodson L, Moore JB. Dietary carbohydrates and fats in NAFLD. Nat Rev Gastroenterol Hepatol. 2021;18(11):770-786.<\/p>\n

Luukkonen PK, Dufour S, Lyu K, Zhang XM, Hakkarainen A, Lehtim\u00e4ki TE, Cline GW, Petersen KF, Shulman GI*, Yki-J\u00e4rvinen H*. Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2020;117(13):7347-7354.<\/p>\n

Luukkonen PK, Tukiainen T, Juuti A, Sammalkorpi H, Nidhina Haridas PA, Niemel\u00e4 O, Arola J, Orho-Melander M, Hakkarainen A, Kovanen PT, Dwivedi O, Groop L, Hodson L, Gastaldelli A, Hy\u00f6tyl\u00e4inen T, Oresic M, Yki-J\u00e4rvinen H. Hydroxysteroid 17-\u03b2 dehydrogenase increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease. JCI Insight. 2020;5(5).<\/p>\n

Luukkonen PK*, Nick A*, H\u00f6ltt\u00e4-Vuori M, Thiele C, Isokuortti E, Lallukka-Br\u00fcck S, Zhou Y, Hakkarainen A, Lundbom N, Peltonen M, Orho-Melander M, Ore\u0161i\u010d M, Hy\u00f6tyl\u00e4inen T, Hodson L, Ikonen E, Yki-J\u00e4rvinen H. Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids. JCI Insight. 2019;4(16):e127902.<\/p>\n

Luukkonen PK, S\u00e4devirta S, Zhou Y, Kayser B, Ali A, Ahonen L, Lallukka S, Pelloux V,Gaggini M, Jian C, Hakkarainen A, Lundbom N, Gylling H, Salonen A, Ore\u0161i\u010d M, Hy\u00f6tyl\u00e4inen T, Orho-Melander M, Rissanen A, Gastaldelli A, Cl\u00e9ment K, Hodson L, Yki-J\u00e4rvinen H. Saturated Fat is More Metabolically Harmful for the Human Liver than Unsaturated Fat or Simple Sugars. Diabetes Care. 2018;41(8):1732-1739.<\/p>\n

Luukkonen PK*, Zhou Y*, S\u00e4devirta S, Leivonen M, Arola J, Ore\u0161i\u010d M, Hy\u00f6tyl\u00e4inen T, Yki-J\u00e4rvinen H. Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease. J Hepatol. 2016;64:1167-75.<\/p>\n

Finansi\u00e4rer av forskningen<\/h3>\n

Finlands Akademi
\nEmil Aaltosen S\u00e4\u00e4ti\u00f6
\nEU Horizon 2020, Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS)
\nStatens forskningsfinansiering
\nSuomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6
\nInstrumentariumin Tiedes\u00e4\u00e4ti\u00f6
\nNovo Nordisk Foundation
\nOrionin Tutkimuss\u00e4\u00e4ti\u00f6
\nSigrid Jus\u00e9lius Stiftelse
\nHelsingfors universitet<\/p>\n

F\u00f6lj<\/h3>\n

Visit the group\u2019s website at the University of Helsinki<\/a><\/p>\n\n <\/div>\n <\/section>\n\n <\/div>\n","protected":false},"template":"","class_list":["post-687","research-groups","type-research-groups","status-publish","hentry"],"acf":[],"yoast_head":"\nFettleversjukdom och diabetes - Minervainstitutet<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/minervainstitute.fi\/sv\/forskningsgrupper\/fettleversjukdom-och-diabetes\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fettleversjukdom och diabetes - Minervainstitutet\" \/>\n<meta property=\"og:url\" content=\"https:\/\/minervainstitute.fi\/sv\/forskningsgrupper\/fettleversjukdom-och-diabetes\/\" \/>\n<meta property=\"og:site_name\" content=\"Minervainstitutet\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-08T13:41:07+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/minervainstitute.fi\\\/sv\\\/forskningsgrupper\\\/fettleversjukdom-och-diabetes\\\/\",\"url\":\"https:\\\/\\\/minervainstitute.fi\\\/sv\\\/forskningsgrupper\\\/fettleversjukdom-och-diabetes\\\/\",\"name\":\"Fettleversjukdom och diabetes - 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