{"id":686,"date":"2026-10-05T07:19:19","date_gmt":"2026-10-05T07:19:19","guid":{"rendered":"https:\/\/minervainstitute.fi\/?post_type=research-groups&p=686"},"modified":"2026-10-08T13:39:05","modified_gmt":"2026-10-08T13:39:05","slug":"lipidsignalering-och-homeostas","status":"publish","type":"research-groups","link":"https:\/\/minervainstitute.fi\/sv\/forskningsgrupper\/lipidsignalering-och-homeostas\/","title":{"rendered":"Lipidsignalering och homeostas"},"content":{"rendered":"
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Gruppledare<\/h3>
\r\nVesa Olkkonen, FD, professor
\r\nvesa.olkkonen@helsinki.fi
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Gruppmedlemmar<\/h3>
\r\nKid T\u00f6rnquist, FD, professor
\r\nP.A. Nidhina Haridas, PhD
\r\nVaishali Chaurasiya, MSc
\r\nMeghana Nagaraj, MSc
\r\nRiikka Kosonen, FM, forskningsassistent<\/p>\n <\/div>\n <\/div>\n
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Utvalda publikationer<\/h3>\n

Chaurasiya V, Pham DD, Harju J, Juuti A, Penttil\u00e4 A, Goud ESK, Nguyen VD, Zhang B Perttunen S, Keskitalo S, Zhou Y, Pietil\u00e4inen KH, Nidhina Haridas1 PA, Olkkonen VM. Human visceral adipose tissue microvascular endothelial cell isolation and establishment of co-culture with white adipocytes to analyze cell-cell communication. Exp Cell Res. 2023 Oct 16:113819. doi: 10.1016\/j.yexcr.2023.113819. Online ahead of print.<\/p>\n

Monteiro-Cardoso VF, Rochin L, Arora A, Houcine A, J\u00e4\u00e4skel\u00e4inen E, Kivel\u00e4 AM, Sauvanet C, Le Bars R, Marien E, Dehairs J, Neveu J, El Khallouki N, Santonico E, Swinnen JV, Tareste D, Olkkonen VM, Giordano F. 2022. ORP5\/8 and MIB\/MICOS link ER-mitochondria and intramitochondrial contacts for non-vesicular transport of phosphatidylserine. Cell Rep. 40:111364.<\/p>\n

Weber-Boyvat M, Kroll J, Trimbuch T, Olkkonen VM, Rosenmund C. 2022. The lipid transporter ORP2 regulates synaptic neurotransmitter release via two distinct mechanisms. Cell Rep 41:111882.<\/p>\n

Ahonen MA, H\u00f6ring M, Nguyen VD, Qadri S, Taskinen JH, Nagaraj M, Wabitsch M, Fischer-Posovszky P, Zhou Y, Liebisch G, Haridas PAN, Yki-J\u00e4rvinen H, Olkkonen VM. 2022. Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes. Mol. Med. 28:68.<\/p>\n

Arora A, Kivel\u00e4 AM, Wang L, Minkeviciene R, Taskinen JH, Zhang B, Koponen A, Sun J, Shirane M, Hotulainen P, Raiborg C, Olkkonen VM. 2022. Protrudin regulates FAK activation, endothelial cell migration and angiogenesis. Cell Mol Life Sci 79:220.<\/p>\n

Takahashi K, Kanerva K, Vanharanta L, Almeida-Souza L, Lietha D, Olkkonen VM, Ikonen E. 2021. ORP2 couples LDL-cholesterol transport to FAK activation by endosomal cholesterol\/PI(4,5)P2 exchange . EMBO J. 40:e106871.<\/p>\n

Tikkanen E, Minicocci I, H\u00e4llfors J, Di Costanzo A, D\u2019Erasmo L, Poggiogalle E, Donini LM, W\u00fcrtz P. Jauhiainen M, Olkkonen VM, Arca M. 2019. Metabolomic signature of angiopoietin-like protein 3 deficiency in fasting and postprandial state, Arterioscler. Thromb. Vasc. Biol. 39:665-74.<\/p>\n

Kentala H, Koponen A, Vihinen H, Pirhonen J, Liebisch G, Pataj Z, Kivel\u00e4 A, Li S, Karhinen L, J\u00e4\u00e4skel\u00e4inen E, Andrews R, Meril\u00e4inen L, Matysik S, Ikonen E, Zhou Y, Jokitalo E, Olkkonen VM. 2018. OSBP-related protein-2 (ORP2): A novel Akt effector that controls cellular energy metabolism. Cell Mol Life Sci 75:4041-57.<\/p>\n

Zhong W, Yi Q, Xu B, Li S, Wang T, Liu F, Zhu B, Hoffmann PR, Ji G, Lei P, Li G, Li J, Li J, Olkkonen VM, Yan D. 2016. ORP4L is essential for T-cell acute lymphoblastic leukemia (T-ALL) cell survival. Nat Commun. 7:12702.<\/p>\n

Weber-Boyvat M, Kentala H, Per\u00e4nen J and Olkkonen VM. 2014. Ligand-dependent localization and function of ORP\u2013VAP complexes at membrane contact sites. Cell. Mol. Life Sci. 72:1967-87.<\/p>\n

Finansi\u00e4rer av forskningen<\/h3>\n

Finska Vetenskaps-Societeten
\nJane ja Aatos Erkkos Stiftelse
\nMedicinska undrst\u00f6dsf\u00f6reningen Liv och H\u00e4lsa r.f.
\nMagnus Ehrnrooths Stiftelse
\nSigrid Jus\u00e9lius Stiftelse<\/p>\n\n <\/div>\n <\/section>\n\n <\/div>\n","protected":false},"template":"","class_list":["post-686","research-groups","type-research-groups","status-publish","hentry"],"acf":[],"yoast_head":"\nLipidsignalering och homeostas - Minervainstitutet<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/minervainstitute.fi\/sv\/forskningsgrupper\/lipidsignalering-och-homeostas\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lipidsignalering och homeostas - Minervainstitutet\" \/>\n<meta property=\"og:url\" content=\"https:\/\/minervainstitute.fi\/sv\/forskningsgrupper\/lipidsignalering-och-homeostas\/\" \/>\n<meta property=\"og:site_name\" content=\"Minervainstitutet\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-08T13:39:05+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/minervainstitute.fi\\\/sv\\\/forskningsgrupper\\\/lipidsignalering-och-homeostas\\\/\",\"url\":\"https:\\\/\\\/minervainstitute.fi\\\/sv\\\/forskningsgrupper\\\/lipidsignalering-och-homeostas\\\/\",\"name\":\"Lipidsignalering och homeostas - 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