{"id":684,"date":"2026-10-05T07:21:51","date_gmt":"2026-10-05T07:21:51","guid":{"rendered":"https:\/\/minervainstitute.fi\/?post_type=research-groups&p=684"},"modified":"2026-10-08T13:36:31","modified_gmt":"2026-10-08T13:36:31","slug":"membranbiologi","status":"publish","type":"research-groups","link":"https:\/\/minervainstitute.fi\/sv\/forskningsgrupper\/membranbiologi\/","title":{"rendered":"Membranbiologi"},"content":{"rendered":"
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Gruppledare<\/h3>
\r\nElina Ikonen, MD, professor
\r\nelina.ikonen@helsinki.fi
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Gruppmedlemmar<\/h3>
\r\nMaarit H\u00f6ltt\u00e4, PhD, \u00e4ldre universitetlektor
\r\nKristiina Kanerva, FD
\r\nMiesje van der Stoel, PhD
\r\nXin Zhou, PhD
\r\nHaoran Li, MSc
\r\nHelj\u00e4 L\u00e5ng, ML
\r\n\u00c1bel Szkalisity, MSc
\r\nLauri Vanharanta, ML
\r\nCsaba V\u00f6r\u00f6s, MSc
\r\nMarkus Konttinen, forskningsassistent
\r\nErika Saari, forskningsassistent
\r\nP\u00e4ivi Kleemola, forskningsassistent
\r\nAnna Uro, Laboratorietekniker<\/p>\n <\/div>\n <\/div>\n
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Utvalda publikationer<\/h3>\n

Sandhu J, Li S, Fairall L, Pfisterer SG, Weston TA, Gurnett JE, Xiao X, Vashi D, Ferrari A, Orozco JL, Kim J, Hartman CL, Strugatsky D, Lee SD, He C, Hong C, Jiang H, Bentolila LA, Gatta AT, Levine TP, Rajbhandari P, Sallam T, Ferng A, Lee R, Ford DA, Young SG, Ikonen E*, Schwabe JWR*, and Tontonoz P* (2018) Aster proteins facilitate nonvesicular plasma membrane to ER cholesterol transport in mammalian cells. Cell, 175: 1-16. * co-senior authors<\/p>\n

Salo VT, Li S, Vihinen H, H\u00f6ltt\u00e4-Vuori M, Szkalisity A, Horvath P, Belevich I, Per\u00e4nen J, Thiele C, Somerharju P, Zhao H, Santinho A, Thiam AR*, Jokitalo E*, and Ikonen E* (2019) Seipin facilitates triglyceride flow to lipid droplet and counteracts droplet ripening via endoplasmic reticulum contact. Dev. Cell, 50: 478-493. *co-corresponding authors<\/p>\n

Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomes R, Prive GG, Annaert W, Schwake M, Heeren J, Lullmann-Rauch R, Grinstein S*, Ikonen E*, Saftig P*, and Neculai D*. (2019) Lysosomal Integral Membrane Protein-2 (LIMP-2\/SCARB2) is involved in lysosomal cholesterol export. Nat. Commun., 10: 3521. *co-corresponding authors<\/p>\n

Gung\u00f6r B, Vanharanta L, H\u00f6ltt\u00e4-Vuori M, Pirhonen J, Petersen NHT, Gramolelli S, Ojala PM, Kirkegaard T, and Ikonen E (2019) HSP70 induces Liver X receptor pathway activation and cholesterol reduction in vitro and in vivo. Mol. Metab., 28: 135-143.<\/p>\n

Li S, Prasanna X, Salo VT, Vattulainen I, and Ikonen E (2019). An efficient auxin-inducible degron system with low basal degradation in human cells. Nat. Methods, 16: 866-869.<\/p>\n

Prasanna X, Salo VT, Li S, Ven K, Vihinen H, Jokitalo E, Vattulainen I, and Ikonen E (2021) Seipin traps triacylglycerols to facilitate their nano-scale clustering in the endoplasmic reticulum membrane. PLoS Biol., 19: e3000998.<\/p>\n

Takahashi K, Kanerva K, Vanharanta L, Almeida-Souza L, Lietha D, Olkkonen VM, and Ikonen E (2021) ORP2 couples LDL-cholesterol transport to FAK activation by endosomal cholesterol\/PI(4,5)P2 exchange. EMBO J., 40: e106871.<\/p>\n

Combot Y, Salo VT, Chadeuf G, H\u00f6ltt\u00e4 M, Ven K, Pulli I, Ducheix S, Pecqueur C, Renoult O, Lak B, Li S, Karhinen L, Belevich I, Le May C, Rieusset J, Le Lay S, Croyal M, Tayeb KS, Vihinen H, Jokitalo E, T\u00f6rnqvist K, Vigoureux C, Cariou B, Magre J, Larhlimi A, Ikonen E*, and Prieur X* (2022) Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes. Cell Rep., 38: 110213. *co-corresponding authors<\/p>\n

Pirhonen J, Szkalisity A, Hagstr\u00f6m J, Kim Y, Migh E, Kovacs M, H\u00f6ltt\u00e4 M, Per\u00e4nen J, Sepp\u00e4nen J, Haglund C, Gil J, Rezeli M, Malm J, Horvath P, Marko-Varga Gy, Puolakkainen P, and Ikonen E (2022) Lipid metabolic reprogramming extends beyond histologic tumor demarcations in operable human pancreatic cancer. Cancer Res., 82: 3932-3949.<\/p>\n

Dumesnil C, Vanharanta L, Prasanna X, Omrane M, Carpentier M, Enkavi G, Vattulainen I*, Ikonen E*, and Thiam AR* (2023) Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols. Nat. Commun., 14: 915. *co-corresponding authors<\/p>\n

Finansi\u00e4rer av forskningen<\/h3>\n

Finlands Akademi
\nEU MCSA
\nFondation Leducq
\nJane ja Aatos Erkkos Stiftelse
\nSigrid Jus\u00e9lius Stiftelse<\/p>\n

F\u00f6lj<\/h3>\n

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