{"id":680,"date":"2026-10-05T07:29:36","date_gmt":"2026-10-05T07:29:36","guid":{"rendered":"https:\/\/minervainstitute.fi\/research-groups\/associated-group-neuronal-signaling\/"},"modified":"2026-10-08T13:33:07","modified_gmt":"2026-10-08T13:33:07","slug":"associerad-group-neuronal-signalering","status":"publish","type":"research-groups","link":"https:\/\/minervainstitute.fi\/sv\/forskningsgrupper\/associerad-group-neuronal-signalering\/","title":{"rendered":"Associerad group: Neuronal signalering"},"content":{"rendered":"
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Gruppledare<\/h3>
\r\nDan Lindholm, MD, professor
\r\ndan.lindholm@helsinki.fi
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Gruppmedlemmar<\/h3>
\r\nOve Eriksson, FD
\r\nMiriana Scordino, MSc
\r\nChiara Valencia, MSc
\r\nUrho Kere, medicinstudent<\/p>\n <\/div>\n <\/div>\n
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Utvalda publikationer<\/h3>\n

Ajoolabady A, Lindholm D, Ren J, Pratic\u00f2 D (2022) ER Stress and UPR in Alzheimer’s Disease: Mechanisms, Pathogenesis, Treatment. Cell Death Dis. 13:706.<\/p>\n

Cascone, A., Lalowski, M., Lindholm, D., & Eriksson, O. (2022). Unveiling the Function of the Mitochondrial Filament-Forming Protein LACTB in Lipid Metabolism and Cancer. Cells, 11<\/i>(10), 1703.<\/p>\n

Do, H. T., Tselykh, T. V., M\u00e4kel\u00e4, J., Ho, T. H., Olkkonen, V. M., Bornhauser, B. C., Korhonen, L., Zelcer, N. & Lindholm, D. (2012) Fibroblast Growth Factor-21 (FGF21) Regulates Low-density Lipoprotein Receptor (LDLR) Levels in Cells via the E3-ubiquitin Ligase Mylip\/Idol and the Canopy2 (Cnpy2)\/Mylip-interacting Saposin-like Protein (Msap). J Biol Chem. 287, 12602-12611<\/p>\n<\/div>\n

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Hyrskyluoto A, Bruelle C, Lundh SH, Do HT, Kivinen J, Rappou E, Reijonen S, Waltimo T, Peters\u00e9n \u00c5, Lindholm D, Korhonen L. (2014) Ubiquitin specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1 a. Hum Mol Genetics 23, 5928-5939.<\/p>\n

Korhonen L, Paul ER, Karin W\u00e5hl\u00e9n K, Haring L, Vasar E, Vaheri A, Lindholm D. (2023) Multivariate analyses of immune markers reveal increases in plasma EN-RAGE in first-episode psychosis patients. Translational Psychiatry, 13(1):326.doi 10.1038\/s41398-023-02627-8<\/p>\n

Lindholm D, Korhonen L, Eriksson O, and K\u00f5ks S (2017) Recent Insights into the Role of Unfolded Protein Response in ER stress in Health and Disease. Frontiers in Cell and Dev. Biol., 5:48.<\/p>\n

Pham DD, Bruelle C, Thi Do H, Pajanoja C, Jin C, Srinivasan V, Olkkonen VM, Eriksson O, Jauhiainen M, Lalowski M, Lindholm D. (2019) Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells. Cell Death Dis. 11;10(7):537.<\/p>\n

Srinivasan V, Bruelle C, Scifo E, Pham DD, Soliymani R, Lalowski M, Lindholm D. (2020) Dynamic interaction of USP14 with the chaperone HSC70 mediates crosstalk between the proteasome, ER signaling and autophagy. iScience 23(1):100790.<\/p>\n

Srinivasan V, Asghar MY, Zafar S, T\u00f6rnquist K, Lindholm D. (2023) Proliferation and migration of ML1 follicular thyroid cancer cells are inhibited by IU1 targeting USP14: role of proteasome and autophagy flux. Front Cell Dev Biol. 11: 30 aug2023.<\/p>\n

Stepanova P, Kumar D, Cavonius K, Korpikoski J, Sirjala J, Lindholm D, Voutilainen MH (2023) Beneficial behavioral effects of cerebraldopamine neurotrophic factor (CDNF) infusion in the N171-82Q transgenic model of Huntington\u2019s disease. Scientific Report 13:2953.<\/span><\/p>\n

Finansi\u00e4rer av forskningen<\/h3>\n

Doctorandprogrammet i Biomedicin (DPBM)
\nFinska Vetenskaps-Societeten
\nMagnus Ehrnrooths Stiftelse
\nFinska L\u00e4kares\u00e4llskapet
\nMedicinska Underst\u00f6dsf\u00f6reningen Liv och H\u00e4lsa r.f.
\nHelsingfors universitet<\/p>\n

F\u00f6lj<\/h3>\n

Research gate: https:\/\/www.researchgate.net\/profile\/Dan-Lindholm<\/a><\/p>\n\n <\/div>\n <\/section>\n\n <\/div>\n","protected":false},"template":"","class_list":["post-680","research-groups","type-research-groups","status-publish","hentry"],"acf":[],"yoast_head":"\nAssocierad group: Neuronal signalering - Minervainstitutet<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/minervainstitute.fi\/sv\/forskningsgrupper\/associerad-group-neuronal-signalering\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Associerad group: Neuronal signalering - Minervainstitutet\" \/>\n<meta property=\"og:url\" content=\"https:\/\/minervainstitute.fi\/sv\/forskningsgrupper\/associerad-group-neuronal-signalering\/\" \/>\n<meta property=\"og:site_name\" content=\"Minervainstitutet\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-08T13:33:07+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/minervainstitute.fi\\\/sv\\\/forskningsgrupper\\\/associerad-group-neuronal-signalering\\\/\",\"url\":\"https:\\\/\\\/minervainstitute.fi\\\/sv\\\/forskningsgrupper\\\/associerad-group-neuronal-signalering\\\/\",\"name\":\"Associerad group: Neuronal signalering - 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