{"id":2777,"date":"2026-06-17T14:03:39","date_gmt":"2026-06-17T14:03:39","guid":{"rendered":"https:\/\/minervainstitute.fi\/?p=2777"},"modified":"2026-06-17T14:13:22","modified_gmt":"2026-06-17T14:13:22","slug":"ny-gen-bakom-svar-atopisk-sjukdom-identifierad","status":"publish","type":"post","link":"https:\/\/minervainstitute.fi\/sv\/ny-gen-bakom-svar-atopisk-sjukdom-identifierad\/","title":{"rendered":"Ny gen bakom sv\u00e5r atopisk sjukdom identifierad"},"content":{"rendered":"<div id=\"attachment_2770\" style=\"width: 2570px\" class=\"wp-caption alignnone\"><img decoding=\"async\" aria-describedby=\"caption-attachment-2770\" class=\"wp-image-2770 size-full\" src=\"https:\/\/minervainstitute.fi\/wp-content\/uploads\/2026\/06\/DSC_5317-scaled.jpg\" alt=\"\" width=\"2560\" height=\"1704\" srcset=\"https:\/\/minervainstitute.fi\/wp-content\/uploads\/2026\/06\/DSC_5317-200x133.jpg 200w, https:\/\/minervainstitute.fi\/wp-content\/uploads\/2026\/06\/DSC_5317-300x200.jpg 300w, https:\/\/minervainstitute.fi\/wp-content\/uploads\/2026\/06\/DSC_5317-400x266.jpg 400w, https:\/\/minervainstitute.fi\/wp-content\/uploads\/2026\/06\/DSC_5317-600x399.jpg 600w, https:\/\/minervainstitute.fi\/wp-content\/uploads\/2026\/06\/DSC_5317-768x511.jpg 768w, https:\/\/minervainstitute.fi\/wp-content\/uploads\/2026\/06\/DSC_5317-800x532.jpg 800w, https:\/\/minervainstitute.fi\/wp-content\/uploads\/2026\/06\/DSC_5317-1024x682.jpg 1024w, https:\/\/minervainstitute.fi\/wp-content\/uploads\/2026\/06\/DSC_5317-1200x799.jpg 1200w, https:\/\/minervainstitute.fi\/wp-content\/uploads\/2026\/06\/DSC_5317-1536x1022.jpg 1536w, https:\/\/minervainstitute.fi\/wp-content\/uploads\/2026\/06\/DSC_5317-scaled.jpg 2560w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" \/><p id=\"caption-attachment-2770\" class=\"wp-caption-text\">Heikki Koistinen, gruppledare f\u00f6r forskningsgruppen \u00c4mnesoms\u00e4ttning.<\/p><\/div>\n<p>&nbsp;<\/p>\n<p><strong>Forskare vid forskargruppen \u00c4mnesoms\u00e4ttning vid Medicinska forskningsinstitutet Minerva har medverkat i en internationell studie som visar att biallelisk OSMR-brist orsakar en tidigare ok\u00e4nd prim\u00e4r atopisk sjukdom. OSMR\u03b2 (onkostatin M-receptor beta), som kodas av genen OSMR, \u00e4r en cytokinreceptorsubenhet som kr\u00e4vs f\u00f6r signalering via onkostatin M (OSM) och IL-31.<\/strong><\/p>\n<p><span style=\"font-weight: 400;\">Forskarna identifierade flera patienter med \u00e4rftliga bialleliska funktionsf\u00f6rlustvarianter i OSMR. Samtliga uppvisade en liknande sjukdomsbild med tidigt debuterande, sv\u00e5r och utbredd atopisk dermatit (eksem), eosinofili samt kraftigt f\u00f6rh\u00f6jda IgE-niv\u00e5er i blodet.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">De OSMR\u03b2-varianter som identifierades hos patienterna <\/span><span style=\"font-weight: 400;\">kunde inte lokaliseras p\u00e5 cellens yta<\/span><span style=\"font-weight: 400;\">, vilket ledde till en selektiv f\u00f6rlust av OSM-beroende signalering. Ytterligare funktionella studier bekr\u00e4ftade att sjukdomen orsakas av f\u00f6rlust av OSMR normala funktion.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Studien kombinerade kliniska observationer, genomik, immunologi och funktionella biologiska analyser under ledning av en internationell forskargrupp. Resultaten publicerades den 28 maj 2026 i <\/span><i><span style=\"font-weight: 400;\">Journal of Human Immunity<\/span><\/i><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Du hittar studien h\u00e4r: <\/span><a href=\"https:\/\/rupress.org\/jhi\/article\/2\/4\/e20260067\/282637\/Human-germline-biallelic-loss-of-function-OSMR\"><span style=\"font-weight: 400;\">https:\/\/rupress.org\/jhi\/article\/2\/4\/e20260067\/282637\/Human-germline-biallelic-loss-of-function-OSMR<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Forskare vid forskargruppen \u00c4mnesoms\u00e4ttning vid Medicinska forskningsinstitutet Minerva har  [&#8230;]<\/p>\n","protected":false},"author":7,"featured_media":2770,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-2777","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-okategoriserad"],"_links":{"self":[{"href":"https:\/\/minervainstitute.fi\/sv\/wp-json\/wp\/v2\/posts\/2777","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/minervainstitute.fi\/sv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minervainstitute.fi\/sv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minervainstitute.fi\/sv\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/minervainstitute.fi\/sv\/wp-json\/wp\/v2\/comments?post=2777"}],"version-history":[{"count":1,"href":"https:\/\/minervainstitute.fi\/sv\/wp-json\/wp\/v2\/posts\/2777\/revisions"}],"predecessor-version":[{"id":2778,"href":"https:\/\/minervainstitute.fi\/sv\/wp-json\/wp\/v2\/posts\/2777\/revisions\/2778"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/minervainstitute.fi\/sv\/wp-json\/wp\/v2\/media\/2770"}],"wp:attachment":[{"href":"https:\/\/minervainstitute.fi\/sv\/wp-json\/wp\/v2\/media?parent=2777"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minervainstitute.fi\/sv\/wp-json\/wp\/v2\/categories?post=2777"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minervainstitute.fi\/sv\/wp-json\/wp\/v2\/tags?post=2777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}