{"id":740,"date":"2026-06-17T14:03:16","date_gmt":"2026-06-17T14:03:16","guid":{"rendered":"https:\/\/minervainstitute.fi\/?post_type=news&p=740"},"modified":"2026-10-08T15:06:11","modified_gmt":"2026-10-08T15:06:11","slug":"ny-gen-bakom-svar-atopisk-sjukdom-identifierad","status":"publish","type":"news","link":"https:\/\/minervainstitute.fi\/sv\/nyheter\/ny-gen-bakom-svar-atopisk-sjukdom-identifierad\/","title":{"rendered":"Ny gen bakom sv\u00e5r atopisk sjukdom identifierad"},"content":{"rendered":"

\"\"<\/p>\n

Heikki Koistinen, gruppledare f\u00f6r forskningsgruppen \u00c4mnesoms\u00e4ttning.<\/p>\n

Forskare vid forskargruppen \u00c4mnesoms\u00e4ttning vid Medicinska forskningsinstitutet Minerva har medverkat i en internationell studie som visar att biallelisk OSMR-brist orsakar en tidigare ok\u00e4nd prim\u00e4r atopisk sjukdom. OSMR\u03b2 (onkostatin M-receptor beta), som kodas av genen OSMR, \u00e4r en cytokinreceptorsubenhet som kr\u00e4vs f\u00f6r signalering via onkostatin M (OSM) och IL-31.<\/strong><\/p>\n

Forskarna identifierade flera patienter med \u00e4rftliga bialleliska funktionsf\u00f6rlustvarianter i OSMR. Samtliga uppvisade en liknande sjukdomsbild med tidigt debuterande, sv\u00e5r och utbredd atopisk dermatit (eksem), eosinofili samt kraftigt f\u00f6rh\u00f6jda IgE-niv\u00e5er i blodet.<\/p>\n

De OSMR\u03b2-varianter som identifierades hos patienternakunde inte lokaliseras p\u00e5 cellens yta, vilket ledde till en selektiv f\u00f6rlust av OSM-beroende signalering. Ytterligare funktionella studier bekr\u00e4ftade att sjukdomen orsakas av f\u00f6rlust av OSMR normala funktion.<\/p>\n

Studien kombinerade kliniska observationer, genomik, immunologi och funktionella biologiska analyser under ledning av en internationell forskargrupp. Resultaten publicerades den 28 maj 2026 iJournal of Human Immunity<\/i>.<\/p>\n

Du hittar studien h\u00e4r:https:\/\/rupress.org\/jhi\/article\/2\/4\/e20260067\/282637\/Human-germline-biallelic-loss-of-function-OSMR<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Heikki Koistinen, gruppledare f\u00f6r forskningsgruppen \u00c4mnesoms\u00e4ttning. Forskare vid forskargruppen \u00c4mnesoms\u00e4ttning vid Medicinska forskningsinstitutet Minerva har medverkat i en internationell studie som visar att biallelisk OSMR-brist orsakar en tidigare ok\u00e4nd prim\u00e4r atopisk sjukdom. OSMR\u03b2 (onkostatin M-receptor beta), som kodas av genen OSMR, \u00e4r en cytokinreceptorsubenhet som kr\u00e4vs f\u00f6r signalering via onkostatin M (OSM) och IL-31. Forskarna […]<\/p>\n","protected":false},"template":"","class_list":["post-740","news","type-news","status-publish","hentry"],"acf":[],"yoast_head":"\nNy gen bakom sv\u00e5r atopisk sjukdom identifierad - Minervainstitutet<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/minervainstitute.fi\/sv\/nyheter\/ny-gen-bakom-svar-atopisk-sjukdom-identifierad\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ny gen bakom sv\u00e5r atopisk sjukdom identifierad - Minervainstitutet\" \/>\n<meta property=\"og:description\" content=\"Heikki Koistinen, gruppledare f\u00f6r forskningsgruppen \u00c4mnesoms\u00e4ttning. Forskare vid forskargruppen \u00c4mnesoms\u00e4ttning vid Medicinska forskningsinstitutet Minerva har medverkat i en internationell studie som visar att biallelisk OSMR-brist orsakar en tidigare ok\u00e4nd prim\u00e4r atopisk sjukdom. OSMR\u03b2 (onkostatin M-receptor beta), som kodas av genen OSMR, \u00e4r en cytokinreceptorsubenhet som kr\u00e4vs f\u00f6r signalering via onkostatin M (OSM) och IL-31. 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Forskare vid forskargruppen \u00c4mnesoms\u00e4ttning vid Medicinska forskningsinstitutet Minerva har medverkat i en internationell studie som visar att biallelisk OSMR-brist orsakar en tidigare ok\u00e4nd prim\u00e4r atopisk sjukdom. OSMR\u03b2 (onkostatin M-receptor beta), som kodas av genen OSMR, \u00e4r en cytokinreceptorsubenhet som kr\u00e4vs f\u00f6r signalering via onkostatin M (OSM) och IL-31. 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