{"id":714,"date":"2024-09-17T07:01:46","date_gmt":"2024-09-17T07:01:46","guid":{"rendered":"https:\/\/minervainstitute.fi\/?post_type=news&p=714"},"modified":"2026-10-08T14:37:30","modified_gmt":"2026-10-08T14:37:30","slug":"disputation-4-10-2024-juuso-taskinen","status":"publish","type":"news","link":"https:\/\/minervainstitute.fi\/sv\/nyheter\/disputation-4-10-2024-juuso-taskinen\/","title":{"rendered":"Disputation 4.10.2024: Juuso Taskinen"},"content":{"rendered":"

Disputation fredagen den 4.10.2024 kl. 12:15-14:15<\/p>\n

Juuso Taskinen: Rollen f\u00f6r endoplasmatiska retikulummembranets kontaktst\u00e4llen i m\u00e4nskliga endotelceller.<\/a><\/p>\n

Mets\u00e4tieteiden talo, Raisio-sali (ls B2), Latokartanokaari 7, Helsingfors<\/p>\n

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Juuso Taskinen, fr\u00e5n gruppen f\u00f6r Lipidsignalering och Homeostas vid Minervainstitutet, kommer att f\u00f6rsvara sin avhandling den 4 oktober 2024 om ER-membrankontakternas roll i endotelcellers fysiologi.<\/p>\n

Endotelceller bildar det inre lagret av blod- och lymfk\u00e4rl och reglerar bland annat transporten av n\u00e4rings\u00e4mnen och syre mellan blod och v\u00e4vnader, hemostas, blodkoagulering och inflammatoriska reaktioner. St\u00f6rningar i endotelcellers funktion spelar en viktig roll i stora folksjukdomar s\u00e5som hj\u00e4rt- och k\u00e4rlsjukdomar, typ 2-diabetes och cancer. I sitt arbete studerade Taskinen de globala effekterna av att h\u00e4mma eller minska komponenterna i de membrankontakter som bildas av endoplasmatiskt retikulum (ER) p\u00e5 endotelcellernas funktion, med m\u00e4nniskans navelstr\u00e4ngsvenendotelceller (HUVEC) som modell. Han minskade dessa kontakter genom att reducera niv\u00e5erna av VAPA- och VAPB-proteiner eller farmakologiskt h\u00e4mma aktiviteten hos OSBP- eller ORP7-proteiner som \u00e4r involverade i dessa kontakter. Resultaten avsl\u00f6jade de m\u00e5ngfacetterade effekterna av att h\u00e4mma dessa kontakter p\u00e5 cellernas funktion och metabolism: inklusive angiogenes (bildning av nya blodk\u00e4rl), lipidkomposition (inklusive kolesterol och kolesterolestrar), ERs och Golgi-apparatens funktion samt cellernas stress- och inflammatoriska reaktioner. Arbetet visade hur central roll ER-membrankontakter spelar f\u00f6r friska endotelceller och gav insikter om hur st\u00f6rningar i dessa kontakter kan bidra till utvecklingen av sjukdomar.<\/p>\n

Avhandlingen handleddes av professor Vesa Olkkonen. Professor Varpu Marjom\u00e4ki fr\u00e5n Jyv\u00e4skyl\u00e4 universitet fungerar som opponent och professor Pekka Lappalainen fr\u00e5n Helsingfors universitet som kustos. Disputationen \u00e4ger rum den 4 oktober 2024 kl. 12.00 i Raisiosalen (f\u00f6rel\u00e4sningssal B2) i Skogsvetenskapsbyggnaden, Latokartanokaari 7, Helsingfors.<\/p>\n","protected":false},"excerpt":{"rendered":"

Disputation fredagen den 4.10.2024 kl. 12:15-14:15 Juuso Taskinen: Rollen f\u00f6r endoplasmatiska retikulummembranets kontaktst\u00e4llen i m\u00e4nskliga endotelceller. Mets\u00e4tieteiden talo, Raisio-sali (ls B2), Latokartanokaari 7, Helsingfors Juuso Taskinen, fr\u00e5n gruppen f\u00f6r Lipidsignalering och Homeostas vid Minervainstitutet, kommer att f\u00f6rsvara sin avhandling den 4 oktober 2024 om ER-membrankontakternas roll i endotelcellers fysiologi. Endotelceller bildar det inre lagret av […]<\/p>\n","protected":false},"template":"","class_list":["post-714","news","type-news","status-publish","hentry"],"acf":[],"yoast_head":"\nDisputation 4.10.2024: Juuso Taskinen - Minervainstitutet<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/minervainstitute.fi\/sv\/nyheter\/disputation-4-10-2024-juuso-taskinen\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Disputation 4.10.2024: Juuso Taskinen - Minervainstitutet\" \/>\n<meta property=\"og:description\" content=\"Disputation fredagen den 4.10.2024 kl. 12:15-14:15 Juuso Taskinen: Rollen f\u00f6r endoplasmatiska retikulummembranets kontaktst\u00e4llen i m\u00e4nskliga endotelceller. Mets\u00e4tieteiden talo, Raisio-sali (ls B2), Latokartanokaari 7, Helsingfors Juuso Taskinen, fr\u00e5n gruppen f\u00f6r Lipidsignalering och Homeostas vid Minervainstitutet, kommer att f\u00f6rsvara sin avhandling den 4 oktober 2024 om ER-membrankontakternas roll i endotelcellers fysiologi. 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Mets\u00e4tieteiden talo, Raisio-sali (ls B2), Latokartanokaari 7, Helsingfors Juuso Taskinen, fr\u00e5n gruppen f\u00f6r Lipidsignalering och Homeostas vid Minervainstitutet, kommer att f\u00f6rsvara sin avhandling den 4 oktober 2024 om ER-membrankontakternas roll i endotelcellers fysiologi. 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