{"id":762,"date":"2026-10-05T07:06:17","date_gmt":"2026-10-05T07:06:17","guid":{"rendered":"https:\/\/minervainstitute.fi\/?post_type=research-groups&p=762"},"modified":"2026-10-12T14:39:06","modified_gmt":"2026-10-12T14:39:06","slug":"sydan-ja-verisuonitutkimus","status":"publish","type":"research-groups","link":"https:\/\/minervainstitute.fi\/fi\/tutkimusryhmat\/sydan-ja-verisuonitutkimus\/","title":{"rendered":"Syd\u00e4n- ja verisuonitutkimus"},"content":{"rendered":"
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Ryhm\u00e4njohtaja<\/h3>
\r\nP\u00e4ivi Lakkisto, MD, DrMedSci, dosentti
\r\npaivi.lakkisto@helsinki.fi
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Ryhm\u00e4nj\u00e4senet<\/h3>
\r\nIlkka Tikkanen, LT, professori
\r\nMika Laine, LT, dosentti
\r\nChunguang Wang, LT, dosentti
\r\nJere Paavola, LT
\r\nHong Wang, PhD
\r\nMikko H\u00e4nninen, LL
\r\nKarri Kalervo, LL
\r\nTuomas M\u00e4ntyl\u00e4, LL
\r\nHeli Segersv\u00e4rd, LL
\r\nIan H\u00e4gerstr\u00f6m, l\u00e4\u00e4ketieteen opiskelija
\r\nKatariina Immonen, LuK, tutkimusavustaja
\r\nSanni Perttunen, LuK, tutkimusavustaja<\/p>\n <\/div>\n <\/div>\n
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Valikoidut julkaisut<\/h3>\n

Segersv\u00e4rd H, Sandholm N, Harjutsalo V, Tikkanen H, Kosonen R, Laine M, Tikkanen I, Groop PH, Lakkisto P; FinnDiane Study Group. Heme oxygenase-1 polymorphisms associate with ischemic cardiac complications and all-cause mortality in type 1 diabetes. Cardiovasc Diabetol 2025; 24:339<\/span><\/p>\n

M\u00e4ntyl\u00e4 T, Wang C, H\u00e4nninen M, Immonen K, J\u00e4ntti T, Lassus J, Tikkanen I, Pulkki K, Devaux Y, Harjola V-P, Lakkisto P. Circulating levels of miR-20b-5p are associated with survival in cardiogenic shock. J Mol Cell Cardiol Plus 2025, 11:100284<\/p>\n

Wang H, Siren J, Perttunen S, Immonen K, Chen YC, Narumanchi S, Kosonen R, Paavola J, Laine M, Tikkanen I, Lakkisto P. Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function. J Cell Mol Med 2024; 28(7):e18243<\/p>\n

Lakkisto P, Dalgaard LT, Belmonte T, Pinto-Sietsma SJ, Devaux Y, De Gonzalo-Calvo D. Development of circulating microRNA-based biomarkers for medical-decision making: a friendly reminder of what should NOT be done. Crit Rev Clin Lab Sci 2023; 60:141-152<\/p>\n

Wang H, Segersv\u00e4rd H, Siren J, Perttunen S, Immonen K, Kosonen R, Chen YC, Tolva J, Laivuori M, M\u00e4yr\u00e4np\u00e4\u00e4 MI, Kovanen PT, Sinisalo J, Laine M, Tikkanen I, Lakkisto P. Tankyrase Inhibition Attenuates Cardiac Dilatation and Dysfunction in Ischemic Heart Failure. Int J Mol Sci. 2022; 23:10059<\/p>\n

Wang C, Taskinen J, Segersv\u00e4rd H, Immonen K, Kosonen R, Tolva JM, M\u00e4yr\u00e4np\u00e4\u00e4 MI, Kovanen PT, Olkkonen VM, Sinisalo J, Laine M, Tikkanen I, Lakkisto P. Alterations of cardiac protein kinases in cyclic nucleotide-dependent signaling pathways in human ischemic heart failure. Front Cardiovasc Med 2022, 9:919355<\/p>\n

H\u00e4nninen M, J\u00e4ntti T, Tolppanen H, Segersv\u00e4rd H, Tarvasm\u00e4ki T, Lassus J, Vausort M, Devaux Y, Sionis A, Tikkanen I, Harjola V-P, Lakkisto P. Association of miR-21-5p, miR-122-5p and miR-320a-3p with 90-day mortality in cardiogenic shock. Int J Mol Sci 2020; 21:7925<\/p>\n

Paavola J, Alakoski T, Ulvila J, Kilpi\u00f6 T, Siren J, Perttunen S, Narumanchi S, Wang H, Lin R, Porvari K, Junttila J, Huikuri H, Immonen K, Lakkisto P, Magga J, Tikkanen I, Kerkel\u00e4 R. Vezf1 regulates cardiac structure and contractile function. EBioMedicine 2020; 51:102608<\/p>\n

Kaartokallio T, Utge S, Klemetti MM, Paananen J, Pulkki K, Romppanen J, Tikkanen I, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Lakkisto P, Laivuori H. Fetal microsatellite in the heme oxygenase 1 promoter is associated with severe and early-onset pre-eclampsia. Hypertension 2018; 71: 95-102<\/p>\n

Segersv\u00e4rd H, Lakkisto P, H\u00e4nninen M, Forsten H, Siren J, Immonen K, Kosonen R, Sarparanta M, Laine M, Tikkanen I. Carbon monoxide releasing molecule improves structural and functional cardiac recovery after myocardial injury. Eur J Pharmacol 2017; 818: 57-66<\/p>\n

\u00a0<\/span><\/p>\n

Rahoitus<\/h3>\n

Aarne Koskelon S\u00e4\u00e4ti\u00f6
\nLaboratoriol\u00e4\u00e4ketieteen Edist\u00e4miss\u00e4\u00e4ti\u00f6 sr
\nValtion tutkimusrahoitus
\nSuomen Kliinisen Kemian yhdistys
\nHelsingin yliopistollinen sairaala HUS
\nJuhani Ahon L\u00e4\u00e4ketieteen Tutkimuss\u00e4\u00e4ti\u00f6 sr.
\nFinska L\u00e4kares\u00e4llskapet
\nMedicinska Underst\u00f6dsf\u00f6reningen Liv och H\u00e4lsa r.f.<\/p>\n

Seuraa meit\u00e4:<\/h3>\n

X: @Lakkisto<\/p>\n\n <\/div>\n <\/section>\n\n <\/div>\n","protected":false},"template":"","class_list":["post-762","research-groups","type-research-groups","status-publish","hentry"],"acf":[],"yoast_head":"\nSyd\u00e4n- ja verisuonitutkimus - Minerva tutkimuslaitos<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/minervainstitute.fi\/fi\/tutkimusryhmat\/sydan-ja-verisuonitutkimus\/\" \/>\n<meta property=\"og:locale\" content=\"fi_FI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Syd\u00e4n- ja verisuonitutkimus - Minerva tutkimuslaitos\" \/>\n<meta property=\"og:url\" content=\"https:\/\/minervainstitute.fi\/fi\/tutkimusryhmat\/sydan-ja-verisuonitutkimus\/\" \/>\n<meta property=\"og:site_name\" content=\"Minerva tutkimuslaitos\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-12T14:39:06+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/minervainstitute.fi\\\/fi\\\/tutkimusryhmat\\\/sydan-ja-verisuonitutkimus\\\/\",\"url\":\"https:\\\/\\\/minervainstitute.fi\\\/fi\\\/tutkimusryhmat\\\/sydan-ja-verisuonitutkimus\\\/\",\"name\":\"Syd\u00e4n- ja verisuonitutkimus - 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