{"id":761,"date":"2026-10-05T07:09:06","date_gmt":"2026-10-05T07:09:06","guid":{"rendered":"https:\/\/minervainstitute.fi\/?post_type=research-groups&p=761"},"modified":"2026-10-12T14:38:42","modified_gmt":"2026-10-12T14:38:42","slug":"hermosolututkimus","status":"publish","type":"research-groups","link":"https:\/\/minervainstitute.fi\/fi\/tutkimusryhmat\/hermosolututkimus\/","title":{"rendered":"Hermosolututkimus"},"content":{"rendered":"
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Ryhm\u00e4njohtaja<\/h3>
\r\nPirta Hotulainen, PhD, Dosentti
\r\npirta.hotulainen@helsinki.fi
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Ryhm\u00e4nj\u00e4senet<\/h3>
\r\nAqsa Jabeen, MSc
\r\nJaan Korpikoski, FM
\r\nMatilda Kuusi, MSc
\r\nDavid Micinski, MSc
\r\nVeera Syrj\u00e4niemi, BSc
\r\nEmilia Toissalo, FM
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Valikoidut julkaisut<\/h3>\n

Micinski D, Hotulainen P. Actin polymerization and longitudinal actin fibers in axon initial segment plasticity. Front Mol Neurosci. 2024; 17:1376997.<\/span><\/p>\n

Khanal P, Boskovic Z, Lahti L, Ghimire A, Minkeviciene R, Opazo P, Hotulainen P. Gas7 Is a Novel Dendritic Spine Initiation Factor. eNeuro. 2023; 10:ENEURO.0344-22.2023.<\/p>\n

Bertling E, Blaesse P, Seja P, Kremneva E, Gateva G, Virtanen MA, Summanen M, Spoljaric I, Uvarov P, Blaesse M, Paavilainen VO, Vutskits L, Kaila K, Hotulainen P*, Ruusuvuori E*. Carbonic anhydrase seven bundles filamentous actin and regulates dendritic spine morphology and density. EMBO Rep. 2021; 22:e50145. *PH and ER contributed equally to this work as senior authors<\/p>\n

Abouelezz A, Stefen H, Segerstr\u00e5le M, Micinski D, Minkeviciene R, Lahti L, Hardeman EC, Gunning PW, Hoogenraad CC, Taira T, Fath T, Hotulainen P. Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment. iScience. 2020; 23:101053.<\/p>\n

Minkeviciene R, Hlushchenko I, Virenque A, Lahti L, Khanal P, Rauramaa T, Koistinen A, Leinonen V, No\u00e9 FM, Hotulainen, P. MIM-Deficient Mice Exhibit Anatomical Changes in Dendritic Spines, Cortex Volume and Brain Ventricles, and Functional Changes in Motor Coordination and Learning. Frontiers in Mol. Neurosci. 2019; 12:276.<\/p>\n

Hlushchenko I, Khanal P, Abouelezz A, Paavilainen VO, Hotulainen P. ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons. Front Cell Neurosci. 2018; 12:217.<\/p>\n

Bertling E, Englund J, Minkeviciene R, Koskinen M, Segerstr\u00e5le M, Castren E, Taira T and Hotulainen P. Actin Tyrosine-53-Phosphorylation in Neuronal Maturation and Synaptic Plasticity. J Neuroscience. 2016; 36:5299-5313.<\/p>\n

Saarikangas J, Kourdougli N, Senju Y, Chazal G, Segerstr\u00e5le M, Kuurne J, Minkeviciene R, Mattila PK, Garrett L, H\u00f6lter SM, Becker L, Racz I, Hans W, Klopstock T, Wurst W, Zimmer A, Fuchs H, Gailus-Durner V, Hrab\u011b de Angelis M, von Ossowski L, Taira T, Lappalainen P, Rivera O, Hotulainen P. MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation. Dev Cell. 2015; 33:644-659.<\/p>\n

Hotulainen P, Hoogenraad CC. Actin in dendritic spines: connecting dynamics to function. J Cell Biol. 2010; 189:619-629.<\/p>\n

Hotulainen P, Llano O, Smirnov S, Tanhuanp\u00e4\u00e4 K, Faix J, Rivera C, Lappalainen P. Defining mechanisms of actin polymerization and depolymerization during dendritic spine morphogenesis. J Cell Biol. 2009; 185:323-339.<\/p>\n

Rahoitus<\/h3>\n

Medicinska underst\u00f6dsf\u00f6reningen Liv och H\u00e4lsa r.f.
\nSigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6<\/span><\/p>\n

Seuraa meit\u00e4:<\/h3>\n

ResearchGate: Pirta Hotulainen
\nReseacher-ID: B-8874-2015
\nORCID: 0000-0003-0764-8582
\nX: @PirtaHotulainen
\nBluesky: @pirtahotulainen.bsky.social<\/p>\n\n <\/div>\n <\/section>\n\n <\/div>\n","protected":false},"template":"","class_list":["post-761","research-groups","type-research-groups","status-publish","hentry"],"acf":[],"yoast_head":"\nHermosolututkimus - Minerva tutkimuslaitos<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/minervainstitute.fi\/fi\/tutkimusryhmat\/hermosolututkimus\/\" \/>\n<meta property=\"og:locale\" content=\"fi_FI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hermosolututkimus - Minerva tutkimuslaitos\" \/>\n<meta property=\"og:url\" content=\"https:\/\/minervainstitute.fi\/fi\/tutkimusryhmat\/hermosolututkimus\/\" \/>\n<meta property=\"og:site_name\" content=\"Minerva tutkimuslaitos\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-12T14:38:42+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/minervainstitute.fi\\\/fi\\\/tutkimusryhmat\\\/hermosolututkimus\\\/\",\"url\":\"https:\\\/\\\/minervainstitute.fi\\\/fi\\\/tutkimusryhmat\\\/hermosolututkimus\\\/\",\"name\":\"Hermosolututkimus - 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