{"id":692,"date":"2026-10-05T07:24:08","date_gmt":"2026-10-05T07:24:08","guid":{"rendered":"https:\/\/minervainstitute.fi\/?post_type=research-groups&p=692"},"modified":"2026-10-12T14:34:49","modified_gmt":"2026-10-12T14:34:49","slug":"aineenvaihdunta","status":"publish","type":"research-groups","link":"https:\/\/minervainstitute.fi\/fi\/tutkimusryhmat\/aineenvaihdunta\/","title":{"rendered":"Aineenvaihdunta"},"content":{"rendered":"
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Ryhm\u00e4njohtaja<\/h3>
\r\nHeikki Koistinen, MD, DrMedSci, professori
\r\nheikki.koistinen@helsinki.fi
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Ryhm\u00e4nj\u00e4senet<\/h3>
\r\nSelina M\u00e4kinen, PhD
\r\nSreesha Sree, PhD
\r\nJenny Illman, MSci
\r\nLeena Kinnunen, Phil kand, research assistant
\r\nHenric Kultalahti, MB<\/p>\n <\/div>\n <\/div>\n
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Valikoidut julkaisut<\/h3>\n

M\u00e4kinen S, Sree S, Ala-Nisula T, Kultalahti H, Koivunen P, Koistinen HA: Activation of the hypoxia-inducible factor pathway by roxadustat improves glucose metabolism in human primary myotubes from men. Diabetologia. 2024; 67:1943-1954. doi: 10.1007\/s00125-024-06185-6. PMID: 38814443<\/p>\n

M\u00e4kinen S, Datta N, Rangarajan S, Nguyen YH, Olkkonen VM, Latva-Rasku A, Nuutila P, Laakso M, Koistinen HA: Finnish-specific AKT2 gene variant leads to impaired insulin signalling in myotubes. Journal of Molecular Endocrinology. 2023 Jan 4;70(2):e210285. doi: 10.1530\/JME-21-0285. Print 2023 Feb 1. PMID: 36409629<\/p>\n

\u00d6hman T, Teppo J, Datta N, M\u00e4kinen S, Varjosalo M, Koistinen HA: Skeletal muscle proteomes reveal downregulation of mitochondrial proteins in transition from prediabetes into type 2 diabetes. iScience 2021 Jun 10;24(7):102712. doi: 10.1016\/j.isci.2021.102712. eCollection 2021 Jul 23. PMID: 34235411<\/p>\n

M\u00e4kinen S, Datta N, Nguyen YH, Kyrylenko P, Laakso M, Koistinen HA: Simvastatin profoundly impairs energy metabolism in primary human muscle cells. Endocrine Connections, 9(11):1103-1113, 2020, doi: 10.1530\/EC-20-0444. PMID: 33295884<\/p>\n

Latva-Rasku A, Honka MJ, Stan\u010d\u00e1kov\u00e1 A, Koistinen HA, Kuusisto J, Guan L, Manning AK, Stringham H, Gloyn AL, Lindgren CM, the T2D-GENES Consortium, Collins FS, Mohlke KL, Scott LJ, Karjalainen T, Nummenmaa L, Boehnke M, Nuutila P, Laakso M: A Partial Loss-of-Function Variant in AKT2 is Associated with Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin Sensitive Tissues: a Genotype-Based Callback Positron Emission Tomography Study. Diabetes 2018 Feb;67(2):334-342. doi: 10.2337\/db17-1142. Epub 2017 Nov 15.PMID:29141982<\/p>\n

Scott LJ*, Erdos MR*, Huyghe JR*, Welch RP*, Beck AT, Wolford BN, Chines PS, Didion JP, Narisu N, Stringham HM, Taylor DL, Jackson AU, Vadlamudi S, Bonnycastle LL, Kinnunen L, Saramies J, Sundvall J, D\u2019Oliveira Albanus R, Kiseleva A, Hensley J, Crawford GE, Jiang H, Wen X, Watanabe RM, Lakka TA, Mohlke KL, Laakso M, Tuomilehto J, Koistinen HA, Boehnke M*, Collins FS*, Parker SCJ*: The genetic regulatory signature of type 2 diabetes in human skeletal muscle. Nature Communications. Jun 29;7:11764, 2016. doi: 10.1038\/ncomms11764. PMID: 27353450<\/p>\n

Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JR, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, M\u00fcller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SC, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MC, Palmer ND, Balkau B, Stan\u010d\u00e1kov\u00e1 A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VK, Park KS, Saleheen D, So WY, Tam CH, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, van der Schouw YT, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA Jr, Thameem F, Wilson G, Wong TY, Nj\u00f8lstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney AS, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, J\u00f8rgensen ME, J\u00f8rgensen T, Ladenvall C, Justesen JM, K\u00e4r\u00e4j\u00e4m\u00e4ki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, Hrab\u00e9 de Angelis M, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O\u2019Rahilly SP, Palmer CN, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syv\u00e4nen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JC, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RC, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJ, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, M\u00e4gi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Burtt NP, Mohlke KL, Meitinger T, Groop L, Abecasis G, Florez JC, Scott LJ, Morris AP, Kang HM, Boehnke M, Altshuler D, McCarthy MI: The genetic architecture of type 2 diabetes. Nature, Jul 11, 536(7614):41-47, 2016. doi: 10.1038\/nature18642. PMID: 27398621<\/p>\n

Skrobuk P, von Kraemer S, Semenova MM, Zitting A, Koistinen HA: Acute exposure to resveratrol inhibits AMPK activity in human skeletal muscle cells. Diabetologia 55:3051-60, 2012. DOI 10.1007\/s00125-012-2691-1.<\/p>\n

Bouzakri K, Zachrisson A, Al-Khalili L, Zhang BB, Koistinen HA, Krook A, Zierath JR : siRNA based gene silencing reveals specialized roles of IRS1\/Akt2 and IRS-2\/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metabolism 4 :89-96, 2006<\/p>\n

Koistinen HA, Galuska D, Chibalin AV, Yang J, Zierath JR, Holman GD, Wallberg-Henriksson H: AICAR (5 amino-imidazole carboxamide riboside) increases glucose transport and cell-surface GLUT4 content in skeletal muscle from Type 2 diabetic subjects. Diabetes 52:1066-1072, 2003<\/p>\n

Rahoittajat<\/h3>\n

HUS-VATR
\nJalmari and Rauha Ahokaan S\u00e4\u00e4ti\u00f6
\nFinska L\u00e4kares\u00e4llskapet
\nMedicinska underst\u00f6dsf\u00f6reningen Liv och H\u00e4lsa r.f<\/p>\n

Seuraa meit\u00e4:<\/h3>\n

https:\/\/researchportal.helsinki.fi\/en\/persons\/heikki-allan-koistinen<\/a><\/p>\n\n <\/div>\n <\/section>\n\n <\/div>\n","protected":false},"template":"","class_list":["post-692","research-groups","type-research-groups","status-publish","hentry"],"acf":[],"yoast_head":"\nAineenvaihdunta - Minerva tutkimuslaitos<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/minervainstitute.fi\/fi\/tutkimusryhmat\/aineenvaihdunta\/\" \/>\n<meta property=\"og:locale\" content=\"fi_FI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Aineenvaihdunta - Minerva tutkimuslaitos\" \/>\n<meta property=\"og:url\" content=\"https:\/\/minervainstitute.fi\/fi\/tutkimusryhmat\/aineenvaihdunta\/\" \/>\n<meta property=\"og:site_name\" content=\"Minerva tutkimuslaitos\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-12T14:34:49+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/minervainstitute.fi\\\/fi\\\/tutkimusryhmat\\\/aineenvaihdunta\\\/\",\"url\":\"https:\\\/\\\/minervainstitute.fi\\\/fi\\\/tutkimusryhmat\\\/aineenvaihdunta\\\/\",\"name\":\"Aineenvaihdunta - 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