{"id":767,"date":"2023-12-28T14:04:04","date_gmt":"2023-12-28T14:04:04","guid":{"rendered":"https:\/\/dev.minervainstitute.fi\/tietoa-tutkimuslaitoksesta\/viimeisimmat-julkaisut\/"},"modified":"2026-05-27T08:24:53","modified_gmt":"2026-05-27T08:24:53","slug":"viimeisimmat-julkaisut","status":"publish","type":"page","link":"https:\/\/minervainstitute.fi\/fi\/tietoa-tutkimuslaitoksesta\/viimeisimmat-julkaisut\/","title":{"rendered":"Viimeisimm\u00e4t julkaisut"},"content":{"rendered":"

Viimeisimm\u00e4t julkaisut<\/h1>\n

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The Nordic Experience of Pediatric Heart-Lung Transplantation.<\/a> van der Have O, Odermarsky M, M\u00f6ller T, Juul K, Jahnukainen T, Weinreich ID,\u00a0Sarkola T, Kaskinen AK, Tran-Lundmark K, W\u00e5hlander H. Clin Transplant. 2026 May;40(5):e70570. doi: 10.1111\/ctr.70570.

\nEvaluation of Genetics in the Association Between Cardiorespiratory Fitness and Health: Insights from a Genome-Wide Polygenic Score for Cardiorespiratory Fitness in the FinnGen and HUNT cohorts.<\/a> Joensuu L, Lukander V, Herranen P, Tynkkynen NP, Kujala U, Lop\u00e9z-Bueno R, Nordeidet AN, Klevjer M, \u00d8vretveit K, Wisl\u00f8ff U, Bye A, Ekelund U, Ollikainen M; FinnGen; Sillanp\u00e4\u00e4 E. Scand J Med Sci Sports. 2026 May;36(5):e70291. doi: 10.1111\/sms.70291.<\/p>\n<\/div><\/div><\/div>

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Targeting metabolism to modify cirrhosis: Lessons from FGF21 therapy in MASH.<\/a>\u00a0Luukkonen PK. J Hepatol. 2026 May;84(5):1007-1009. doi: 10.1016\/j.jhep.2026.03.006. Epub 2026 Mar 19.<\/p>\n

The Silver Jubilee (2025) of Insulin Glargine: Introducing the Era of Long-Acting Insulin Analogues for Diabetes Mellitus.<\/a>\u00a0Bolli GB, Home PD, Lepore M, Riddle MC, Porcellati F, Fanelli CG, Lucidi P,\u00a0Yki-J\u00e4rvinen H, Becker RH, Owens DR. Diabetes Obes Metab. 2026 Apr 27. doi: 10.1111\/dom.70751. Online ahead of print.<\/p>\n

Fiber type-specific expression of LACTB leverages a function in oxidative metabolism.<\/a>\u00a0Alanen KM, Soliymani R, Sarparanta J, Kuure S, Sainio K, Polianskyte Z, Asghar MY, Zangene E, Cascone A, Lalowski M, Hackman P, Lundin J,\u00a0Lindholm D, Eriksson O. Histochem Cell Biol. 2026 Apr 18;164(1):24. doi: 10.1007\/s00418-026-02476-8.<\/p>\n

Quantifying risk modifiers of hereditary hemochromatosis using genomic and electronic health record data.<\/a>\u00a0Toivonen J, Clancy J; FinnGen; \u00c5berg F, Ritari J, Arvas M. JHEP Rep. 2026 Apr;8(4):101774. doi: 10.1016\/j.jhepr.2026.101774. Epub 2026 Feb 6.<\/p>\n

The effect of obesity and aging on NAD+<\/sup>\/Sirtuin metabolism transcription and DNA methylation in subcutaneous adipose tissue of monozygotic twin pairs discordant for BMI.<\/a>\u00a0Lapatto HAK, van der Kolk BW, Muniandy M, Heinonen S, Heikkinen A, Alvarez M, Lee SHT, Jokinen R, Lundbom J, Kuula J, Hakkarainen A, Groop PH, Kaprio J, Tukiainen T,\u00a0Ollikainen M, Pajukanta P, Pirinen E, Pietil\u00e4inen KH. Int J Obes (Lond). 2026 Apr;50(4):797-805. doi: 10.1038\/s41366-025-02007-w. Epub 2026 Jan 5.<\/p>\n

Genetic and environmental effects on weight gain from young adulthood to old age and its association with body mass index in early young adulthood: an individual-based pooled analysis of 16 twin cohorts.<\/a>\u00a0Obeso A, Drouard G, Jelenkovic A, Ordo\u00f1ana JR, S\u00e1nchez-Romera JF, Colodro-Conde L,\u00a0Ollikainen M, Aaltonen S, Corley RP, Huibregtse BM, Medda E, Fagnani C, Toccaceli V, Gatz M, Butler DA, Bartels M, Ligthart L, de Geus EJ, Christensen K, Skytthe A, Kyvik KO, Medland SE, Gordon SD, Rasmussen FE, Tynelius P, Franz CE, Kremen WS, Lyons MJ, Spector T, Mangino M, Lachance G, Magnusson PK, Pedersen NL, Dahl Aslan AK, Duncan GE, Buchwald D, Pyun H, Lee J, Lee SJ, Sung J, Bruins S, Pool R, Eriksson A, Martin NG, Boomsma DI, Kaprio J, Silventoinen K. Int J Obes (Lond). 2026 Apr;50(4):768-776. doi: 10.1038\/s41366-025-01998-w. Epub 2025 Dec 25.PMID:\u00a041444398<\/p>\n

Genetic architecture of lumbar spinal stenosis.<\/a>\u00a0Salo V, M\u00e4\u00e4tt\u00e4 J, Takala J, Heikkil\u00e4 A; FinnGen; Reimann E, M\u00e4gi R; Estonian Biobank Research Team; Reis K, Elhanas AG, Reigo A, Palta P, Esko T, Leinonen V, Karppinen J, Sliz E, Kettunen J. Nat Commun. 2026 Apr 6. doi: 10.1038\/s41467-026-70935-w. Online ahead of print.<\/p>\n

Associations between retinal microvasculature and cognition in middle-aged adults with type 1 diabetes without overt neurological symptoms.<\/a>\u00a0Kyl\u00e4heiko I, Tarkkonen A, Kuusela L, Martola J, Paajanen TI, Virkkala J, Fickweiler W, King GL, Sun JK, Turunen JA, Eriksson MI, Groop PH, Thorn LM, Tatlisumak T, Putaala J, Jokinen H,\u00a0Gordin D; FinnDiane Study Group. Cereb Circ Cogn Behav. 2026 Mar 16;10:100536. doi: 10.1016\/j.cccb.2026.100536. eCollection<\/p>\n

A register-based study of long-term health and social care costs among children with prenatal alcohol exposure.<\/a>\u00a0Jolma M, Koivu-Jolma M,\u00a0Sarkola T, Gissler M, Nissinen NM, Kahila H, Sarajuuri A, Torkki P, Autti-R\u00e4m\u00f6 I, Koponen A. PLoS One. 2026 Mar 11;21(3):e0332113. doi: 10.1371\/journal.pone.0332113. eCollection 2026.<\/p>\n

Lifestyle change accelerates epigenetic ageing in King penguins.<\/a>\u00a0Cristofari R, Davis LR, Bardon G, Nitta Fernandes FA, Figueroa ME, Franzenburg S, Gauthier-Clerc M, Grande F, Heidrich R, Hukkanen M, Le Maho Y,\u00a0Ollikainen M, Paciello E, Rampal P, Stenseth NC, Trucchi E, Zahn S, Le Bohec C, Meyer BS. Nat Commun. 2026 Mar 11;17(1):3795. doi: 10.1038\/s41467-026-70527-8.<\/p>\n

Redox-dependent substrate use in hepatic gluconeogenesis shapes exercise performance.<\/a>\u00a0Luukkonen PK. J Hepatol. 2026 Mar;84(3):673-674. doi: 10.1016\/j.jhep.2025.12.008. Epub 2026 Jan 13.<\/p>\n

Associations Between 40-Year Trajectories of BMI and Proteomic and Epigenetic Aging Clocks: Deciphering Nonlinearity and Interactions.<\/a>\u00a0Drouard G, Argentieri MA, Heikkinen A,\u00a0Ollikainen M, Kaprio J. Aging Cell. 2026 Feb;25(2):e70397. doi: 10.1111\/acel.70397.<\/p>\n

Distinct effects of ketogenic and non-ketogenic weight-loss diets on hepatic steatosis and mitochondrial metabolism in MASLD.<\/a>\u00a0Qadri SF, Porthan K, Dufour S, Lehtim\u00e4ki TE, Petersen KF, Shulman GI, Yki-J\u00e4rvinen H,\u00a0Luukkonen PK. J Hepatol. 2026 Feb 6:S0168-8278(26)00062-0. doi: 10.1016\/j.jhep.2026.02.001. Online ahead of print.<\/p>\n

EpiSmokEr2: a robust epigenetic classifier for smoking status inference using Illumina EPIC methylation data.<\/a>\u00a0Zhu T, Farag\u00f3 T, Bollepalli S, Heikkinen A, Hukkanen M, Raitakari O, Lehtim\u00e4ki T, Korhonen T, Kaprio J, Fang F, Lawrence KG, Sandler DP, Spildrejorde MR, Gervin K, Pan Y, Costeira R, Bell JT,\u00a0Ollikainen M. Epigenomics. 2026 Feb;18(2):205-215. doi: 10.1080\/17501911.2026.2630841. Epub 2026 Feb 17.<\/p>\n

A pilot study on measured insulin sensitivity and estimated glucose disposal rates in adults with type 1 diabetes and diabetic kidney disease.<\/a>\u00a0Simonsen JR,\u00a0Gordin D, Januszewski AS, Jenkins AJ, van Raalte DH, van Baar MJ, Bjornstad P, Thorn LM, Groop PH. Endocrine. 2026 Feb 3;91(1):61. doi: 10.1007\/s12020-025-04503-5.<\/p>\n

Corrigendum to ”Animal models of Huntington’s disease. Pros and cons” [Brain, Behavior, Immunity Health 50 (2025) 101149.<\/a>\u00a0Stepanova P, Eriksson O, Voutilainen MH,\u00a0Lindholm D. Brain Behav Immun Health. 2026 Jan 19;52:101180. doi: 10.1016\/j.bbih.2026.101180. eCollection 2026 Mar.<\/p>\n

Epigenetic aging and lifespan reflect reproductive history in the Finnish Twin Cohort.<\/a>\u00a0Hukkanen M, Kankaanp\u00e4\u00e4 A, Heikkinen A, Kaprio J, Cristofari R,\u00a0Ollikainen M. Nat Commun. 2026 Jan 8;17(1):44. doi: 10.1038\/s41467-025-67798-y.<\/p>\n

Cerebral microbleeds are associated with deficits in cognitive processing speed and executive functions in middle-aged adults with type 1 diabetes.<\/a>\u00a0Kyl\u00e4heiko I, Tarkkonen A, Kuusela L, Martola J, Paajanen TI, Virkkala J, Groop PH, Thorn LM, Tatlisumak T, Putaala J,\u00a0Gordin D, Jokinen H; FinnDiane Study Group. Diabetes Res Clin Pract. 2026 Feb;232:113080. doi: 10.1016\/j.diabres.2025.113080. Epub 2026 Jan 2.<\/p>\n

Characterization of Visceral Adipose Tissue Proteome Reveals Metabolic Changes and Inflammatory Signatures in Severe Obesity.<\/a>\u00a0Dadson P, Honka MJ, Suomi T, Rokka A, Kauhanen S, Salminen P, Helmi\u00f6 M, James P, Elo LL,\u00a0Olkkonen VM, Nuutila P. Obesity (Silver Spring). 2026 Jan;34(1):127-137. doi: 10.1002\/oby.70041. Epub 2025 Oct 12.<\/p>\n

Residual cardiovascular risk is tracked by apolipoprotein B in coronary patients with elevated serum triglyceride levels: the ESC EORP EUROASPIRE IV survey.<\/a>\u00a0Leivisk\u00e4 J, Sundvall J,\u00a0Jauhiainen M, Kotseva K, Tuomilehto J, De Backer G, Tokg\u00f6zo\u011flu L, Reiner Z, De Bacquer D. Clin Chim Acta. 2026 Jan 15;579:120653. doi: 10.1016\/j.cca.2025.120653. Epub 2025 Oct 24.<\/p>\n

Genetic liability to psoriasis predicts severe disease outcomes.<\/a>\u00a0Saklatvala JR, Lessard S, Teder-Laving M, Thomas LF, Ramessur R, Zierer J, \u00c5svold BO, Barton A, Baudry D, Bowes J, Brumpton B, Bruno S, Chandran V, Chatelain C, de Rinaldis E, Elder JT, Ellinghaus D, Foerster J, Franke A, Gladman DD, Gulliver W, H\u00fcffmeier U, Huilaja L, Hveem K, Khader S, Kingo K, Klinger K, Kolbinger F, K\u00f5ks S, Liao W, Nair RP, Nititham J, Rahman P, Reis A, Sagoo MK, Stuart PE, Tasanen K, Traks T, Tsoi LC, Uebe S, Watts K; BSTOP study group; Barker JN, Mahil SK, Langan SM; FinnGen; Estonian Biobank research team; Brown SJ, L\u00f8set M, Paternoster L, Dand N, Smith CH, Simpson MA. Genome Med. 2025 Dec 17;18(1):14. doi: 10.1186\/s13073-025-01561-2.<\/p>\n

Expression, Subcellular Localization, and Mechanistic Analysis of Intellectual Disability Syndrome Protein ABBA.<\/a> Jabeen A, Khanal P, Toissalo E, Lahti L, Minkeviciene R, Kramm A, Rivera C,\u00a0Hotulainen P. Mol Neurobiol. 2025 Dec 8;63(1):271. doi: 10.1007\/s12035-025-05475-3.<\/p>\n

Impact of Preeclampsia Duration on Long-Term Cardiovascular Disease Risk.<\/a>\u00a0Keitaanp\u00e4\u00e4 N, Tyrmi JS, Toivonen E, Huhtala H, Kivel\u00e4 A, Heinonen S, J\u00e4\u00e4skel\u00e4inen T, Laivuori H; FINNPEC Core Investigator Group, FinnGen. Hypertension. 2025 Nov 18. doi: 10.1161\/HYPERTENSIONAHA.125.25054. Online ahead of print.<\/p>\n

Use of new CORE risk score to predict 10 year risk of liver cirrhosis in general population: population based cohort study.<\/a>\u00a0Strandberg R, \u00c5berg F, Asteljoki JV, Luukkonen PK, Salomaa V, Jula A, Lundqvist A, M\u00e4nnist\u00f6 S, Perola M, Talb\u00e4ck M, Hammar N, Hagstr\u00f6m H. BMJ. 2025 Sep 29;390:e083182. doi: 10.1136\/bmj-2024-083182.<\/p>\n

Lipids and lipoproteins in the interstitial tissue fluid regulate the formation of dysfunctional tissue-resident macrophages: Implications for atherogenic, tumorigenic, and obesogenic processes.<\/a>\u00a0Lee-Rueckert M, Jauhiainen M, Kovanen PT, Escol\u00e0-Gil JC. Semin Cancer Biol. 2025 Sep;114:104-127. doi: 10.1016\/j.semcancer.2025.06.008. Epub 2025 Jun 20.<\/p>\n

Heterozygous Korat cats with LDL receptor mutation are asymptomatic and normolipidemic.<\/a>\u00a0Karkamo V, Airas N, Kairento H, Nguyen SD, Jauhiainen M, Metso J, Gr\u00f6nthal T, Knuuttila A, Kareinen L, Hyt\u00f6nen MK, Lohi H, \u00d6\u00f6rni K, Kareinen I. Res Vet Sci. 2025 Sep;193:105784. doi: 10.1016\/j.rvsc.2025.105784. Epub 2025 Jun 27.<\/p>\n

A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison.<\/a>\u00a0Shen X, Barbu M, Caramaschi D, Arathimos R, Czamara D, David FS, Dearman A, Dilkes E, Herrera-Rivero M, Huider F, K\u00fchn L, Lu KC, Palviainen T, Schowe AM, Shireby G, Weihs A, Wong CCY, Davyson E, Casey H, Adams MJ, Allgaier AK, Barber M, Burrage J, Caspi A, Costeira R, Dunn EC, Feldmann L, Frank J, Freisleder FJ, Gadd DA, Greimel E, Hannon E, Harris SE, Homuth G, Howard DM, Iurato S, Korhonen T, Lu TP, Martin NG, Martins J, McDermott E, Meinert S, Navarro P,\u00a0Ollikainen M, Pehl V, Piechaczek C, Scherff AD, Stein F, Streit F, Teumer A, V\u00f6lzke H, van Dongen J, Walker RM, Yusupov N, Arseneault L, Bell JT, Berger K, Binder E, Boomsma DI, Cox SR, Dannlowski U, Evans KL, Fisher HL, Forstner AJ, Grabe HJ, Kaprio J, Kircher T, Kopf-Beck J, Kumari M, Kuo PH, Li QS, Moffitt TE, Mulcahy H, Murphy TM, Schulte-K\u00f6rne G, Mill J, Lewis CM; PGC MDD Working Group; Wray NR, McIntosh AM. Nat Ment Health. 2025;3(10):1152-1167. doi: 10.1038\/s44220-025-00486-4. Epub 2025 Sep 16.

\nAssociation of aerobic fitness and body composition with protein and major lipid class composition of high-density lipoprotein.<\/a>\u00a0L\u00e4hteenm\u00e4ki EI, Lehti S,\u00a0Jauhiainen M, Kankaanp\u00e4\u00e4 A, Soliymani R, Baumann M, Ruhanen H, K\u00e4kel\u00e4 R, Vaara J, Laakkonen EK, \u00d6\u00f6rni K, Kyr\u00f6l\u00e4inen H, Lehti M. Am J Physiol Endocrinol Metab. 2025 Aug 1;329(2):E367-E380. doi: 10.1152\/ajpendo.00130.2025. Epub 2025 Jul 18.<\/p>\n

Icosapent ethyl-induced lipoprotein remodeling and its impact on cardiovascular disease risk markers in normolipidemic individuals.<\/a>\u00a0\u00c4ik\u00e4s L, Kovanen PT, Lorey MB, Laaksonen R, Holopainen M, Ruhanen H, K\u00e4kel\u00e4 R,\u00a0Jauhiainen M, Hermansson M, \u00d6\u00f6rni K. JCI Insight. 2025 Oct 8;10(19):e193637. doi: 10.1172\/jci.insight.193637. eCollection 2025 Oct 8.<\/p>\n

Residual cardiovascular risk is tracked by apolipoprotein B in coronary patients with elevated serum triglyceride levels: the ESC EORP EUROASPIRE IV survey.<\/a>\u00a0Leivisk\u00e4 J, Sundvall J,\u00a0Jauhiainen M, Kotseva K, Tuomilehto J, De Backer G, Tokg\u00f6zo\u011flu L, Reiner Z, De Bacquer D. Clin Chim Acta. 2025 Oct 23:120653. doi: 10.1016\/j.cca.2025.120653. Online ahead of print.<\/p>\n

Adipogenin promotes the development of lipid droplets by binding a dodecameric seipin complex.<\/a>\u00a0Li C, Sun XN, Funcke JB, Vanharanta L, Prasanna X, Gov K, Li Y, Virostek M, Joung C, Joffin N, Kanerva K, Szkalisity A, Kulig W, Straub L, Chen S, Velasco J, Cobb A, La Padula D, Wang MY, Onodera T, V\u00f6r\u00f6s C, Kim DS, Kim M, Varlamov O, Li Y, Liu C, Nawrocki AR, Zhao S, Oh DY, Wang ZV, Gordillo R, Goodman JM, Wynn RM, Henne WM, Vattulainen I, Han Y,\u00a0Ikonen E, Scherer PE. Science. 2025 Nov 6;390(6773):eadr9755. doi: 10.1126\/science.adr9755. Epub 2025 Nov 6.

\nSkeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits.<\/a>\u00a0Wilson EP, Broadaway KA, Parsons VA, Vadlamudi S, Narisu N, Brotman SM, Currin KW, Stringham HM, Erdos MR, Welch R, Holtzman JK, Lakka TA, Laakso M, Tuomilehto J, Boehnke M,\u00a0Koistinen HA, Collins FS, Parker SCJ, Scott LJ, Mohlke KL. Am J Hum Genet. 2025 Sep 23:S0002-9297(25)00359-3. doi: 10.1016\/j.ajhg.2025.09.003. Online ahead of print.<\/p>\n

Transcriptomic and lipidomic profiling provide novel insight into the pathogenesis of monogenic\u00a0SGMS2<\/em>-related osteoporosis.<\/a>\u00a0Pihlstr\u00f6m S, Oghabian A, M\u00e4\u00e4tt\u00e4 K, Legebeke J, M\u00e4kitie RE, Campeau PM, Terhal PA, Botto LD,\u00a0Olkkonen VM, M\u00e4kitie O, Pekkinen M. JBMR Plus. 2025 Aug 13;9(10):ziaf128. doi: 10.1093\/jbmrpl\/ziaf128. eCollection 2025 Oct.<\/p>\n

Long-term impact of stressful life events on breast cancer risk: A 36-year genetically informed prospective study in the Finnish Twin Cohort.<\/a>\u00a0Azzi E, Bode H, Palviainen T, Hukkanen M,\u00a0Ollikainen M, Kaprio J. Int J Cancer. 2025 Sep 13. doi: 10.1002\/ijc.70154. Online ahead of print.<\/p>\n

Insights into the vascular aging burden in young adults with embolic stroke of undetermined source.<\/a>\u00a0Kakaletsis N, Gordin D, Martinez-Majander N, Joutsi-Korhonen L, Salopuro T, Adeshara K, Sibolt G, Curtze S, Pirinen J, Soinne L, Sairanen T, Suihko S, Lehto M, Sinisalo J, Tatlisumak T, Groop PH, Putaala J. J Neurol Sci. 2025 Sep 15;476:123642. doi: 10.1016\/j.jns.2025.123642. Epub 2025 Jul 28.<\/p>\n

TOM1 G307D variant impairs interaction with TOLLIP, autophagosome-lysosome fusion and regulation of innate immunity.<\/a> L\u00e5ng HKM, Roach TG, H\u00f6ltt\u00e4 M, Keskitalo S, Varjosalo M, Heiskanen K, Collins MV, Sepp\u00e4nen MRJ, Capelluto DGS, Ikonen E, Ryh\u00e4nen SJ. Dis Model Mech. 2025 Sep 12:dmm.052140. doi: 10.1242\/dmm.052140. Online ahead of print.<\/p>\n

Kinase inhibitor boosts liver regeneration and prevents liver failure.<\/a>\u00a0Luukkonen PK. J Hepatol. 2025 Sep 5:S0168-8278(25)02445-6. doi: 10.1016\/j.jhep.2025.08.010. Online ahead of print.<\/p>\n

Current Status of Fetal Echocardiography Imaging and Fetal Counseling Fellow Training in 29 European Countries.<\/a>\u00a0Sarkola T, Seale AN, Tulzer A, Duignan SM, Grzyb A, Tuo G, Vanhie E, McMahon CJ; Fetal Cardiology Working Group of the AEPC. Pediatr Cardiol. 2025 Sep 1. doi: 10.1007\/s00246-025-04006-0. Online ahead of print.<\/p>\n

Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol.<\/a>\u00a0Zhou X, van der Stoel MM, Kaptan S, Li H, Li S, H\u00f6ltt\u00e4 M, Vihinen H, Jokitalo E, Thiele C, Pietil\u00e4inen O, Morioka S, Sasaki J, Sasaki T, Vattulainen I, Ikonen E. Nat Commun. 2025 Aug 21;16(1):7808. doi: 10.1038\/s41467-025-63125-7.<\/p>\n

Heme oxygenase-1 polymorphisms associate with ischemic cardiac complications and all-cause mortality in type 1 diabetes.<\/a>\u00a0Segersv\u00e4rd H, Sandholm N, Harjutsalo V, Tikkanen H, Kosonen R, Laine M, Tikkanen I, Groop PH, Lakkisto P; FinnDiane Study Group. Cardiovasc Diabetol. 2025 Aug 18;24(1):339. doi: 10.1186\/s12933-025-02895-2.<\/p>\n

Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty.<\/a>\u00a0Mak JKL, Qin C, Kr\u00fcger M, Kuukka A; FinnGen; H\u00e4gg S, Lin J, Jylh\u00e4v\u00e4 J. Nat Aging. 2025 Aug;5(8):1589-1600. doi: 10.1038\/s43587-025-00925-y. Epub 2025 Aug 5.<\/p>\n

Precision in Liver Diagnosis: Varied Accuracy Across Subgroups and the Need for Variable Thresholds in Diagnosis of MASLD.<\/a>\u00a0Vali Y, van Dijk AM, Lee J, Boursier J, Ratziu V, Yunis C, Schattenberg JM, Valenti L, Gomez MR, Schuppan D, Petta S, Allison M, Hartman ML, Porthan K, Dufour JF, Bugianesi E, Gastadelli A, Derdak Z, Fournier-Poizat C, Shumbayawonda E, Kalutkiewicz M, Yki-Jarvinen H, Ekstedt M, Geier A, Trylesinski A, Francque S, Brass C, Pavlides M, Holleboom AG, Nieuwdorp M, Anstee QM, Bossuyt PM; LITMUS investigators. Liver Int. 2025 Feb;45(2):e16240. doi: 10.1111\/liv.16240.<\/p>\n

Polygenic prediction of body mass index and obesity through the life course and across ancestries.<\/a>\u00a0Smit RAJ, Wade KH, Hui Q, Arias JD, Yin X, Christiansen MR, Yengo L, Preuss MH, Nakabuye M, Rocheleau G, Graham SE, Buchanan VL, Chittoor G, Graff M, Guindo-Mart\u00ednez M, Lu Y, Marouli E, Sakaue S, Spracklen CN, Vedantam S, Wilson EP, Chen SH, Ferreira T, Ji Y, Karaderi T, L\u00fcll K, Machado M, Malden DE, Medina-Gomez C, Moore A, R\u00fceger S, Akiyama M, Allison MA, Alvarez M, Andersen MK, Appadurai V, Arbeeva L, Bartell E, Bhaskar S, Bielak LF, Bis JC, Bollepalli S, Bork-Jensen J, Bradfield JP, Bradford Y, Brandl C, Braund PS, Brody JA, Broeckel U, Burgdorf KS, Cade BE, Cai Q, Camarda S, Campbell A, Ca\u00f1adas-Garre M, Chai JF, Chesi A, Choi SH, Christofidou P, Couture C, Cuellar-Partida G, Danning R, Degenhardt F, Delgado GE, Delitala A, Demirkan A, Deng X, Dietl A, Dimitriou M, Dimitrov L, Dorajoo R, Eichelmann F, Eliasen AU, Engmann JE, Erdos MR, Fairhurst-Hunter Z, Farmaki AE, Faul JD, Fernandez-Lopez JC, Forer L, Frank M, Freitag-Wolf S, Fritsche LG, Fuchsberger C, Galesloot TE, Gao Y, Geller F, Giannakopoulou O, Giulianini F, Gjesing AP, Goel A, Gordon SD, Gorski M, Grove J, Guo X, Gustafsson S, Haessler J, Hansen TF, Havulinna AS, Haworth SJ, Heard-Costa N, Hemerich D, Highland HM, Hi\u2026See abstract for full author list \u2794<\/a>\u00a0Nat Med. 2025 Jul 21. doi: 10.1038\/s41591-025-03827-z. Online ahead of print.<\/p>\n

No evidence from euglycaemic-hyperinsulinaemic clamp studies for greater insulin sensitivity in adults with type 1 diabetes using insulin pump versus multiple daily insulin injections-Post hoc meta-analysis.<\/a>\u00a0Januszewski AS, Snaith JR, Grzelka-Wozniak A, Simonsen JRA, Sachithanandan N, Ward GM, O’Neal DN,\u00a0Gordin D, Thorn LM, Groop PH, Uruska AA, Zozulinska-Ziolkiewicz DA, Jenkins AJ, Greenfield JR. Diabetes Obes Metab. 2025 Jul 1. doi: 10.1111\/dom.16487. Online ahead of print.<\/p>\n

Tirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT-MMO trial.<\/a>\u00a0Lam CSP, Rodriguez A, Aminian A, Ferrannini E, Heerspink HJL, Jastreboff AM, Laffin LJ, Pandey A, Ray KK, Ridker PM, Sanyal AJ,\u00a0Yki-Jarvinen H, Mason D, Strzelecki M, Bartee AK, Cui C, Hurt K, Linetzky B, Bunck MC, Nissen SE. Obesity (Silver Spring). 2025 Jun 22. doi: 10.1002\/oby.24332. Online ahead of print.<\/p>\n

Genetic Loci Associated With Periodontitis: The FinnGen Study Based on National Health Registers.<\/a>\u00a0Salminen A, Hyv\u00e4rinen K, Ritari J, Caetano A, Kambur O, M\u00e4ntyl\u00e4 P, Yilmaz M, Sinisalo J; FinnGen; Perola M, Havulinna A, Nibali L, G\u00fcrsoy UK, Pussinen PJ. J Clin Periodontol. 2025 Jul 19. doi: 10.1111\/jcpe.14193. Online ahead of print.<\/p>\n

Sympathetic activation of adipose tissue lipolysis underlies overnutrition-induced metabolic dysfunction.<\/a>\u00a0Luukkonen PK. J Hepatol. 2025 Jun 18:S0168-8278(25)02252-4. doi: 10.1016\/j.jhep.2025.05.021. Online ahead of print.<\/p>\n

Impact of different hypertensive disorders of pregnancy on cardiovascular disease risk and all-cause mortality in women with type 1 diabetes.<\/a>\u00a0Rimpel\u00e4inen K, Jansson Sigfrids F,\u00a0Gordin D, Klemetti MM, Harjutsalo V, Groop PH, Thorn LM; FinnDiane Study Group. Cardiovasc Diabetol. 2025 Jun 14;24(1):255. doi: 10.1186\/s12933-025-02804-7.<\/p>\n

A proteomic signature of healthspan.<\/a>\u00a0Kuo CL, Liu P, Drouard G, Vuoksimaa E, Kaprio J,\u00a0Ollikainen M, Chen Z, Pilling LC, Atkins JL, Fortinsky RH, Kuchel GA, Diniz BS. Proc Natl Acad Sci U S A. 2025 Jun 10;122(23):e2414086122.<\/p>\n

Cardiometabolic health 8-12\u00a0years after pre-eclampsia: Role of obesity and gestational diabetes (FINNCARE study).<\/a>\u00a0Kivel\u00e4 A, Renlund-Vikstr\u00f6m M, Heinonen S,\u00a0Sarkola T, Laivuori H, J\u00e4\u00e4skel\u00e4inen T. Pregnancy Hypertens. 2025 Jun 9;41:101226. doi: 10.1016\/j.preghy.2025.101226. Online ahead of print.<\/p>\n

Genome-wide interaction study with BMI identifies CYP7A1 and GIPR as genetic modulators of MASLD.<\/a>\u00a0Jamialahmadi O, Mujica E, Morris L, Mancina RM, Ciociola E, Qadri SF, Maurotti S, Malvestiti F, Li-Gao R, Ronzoni L, Tavaglione F, Maude H, Allalou A, Emmanouilidou A, Vespasiani-Gentilucci U, Rosendaal FR,\u00a0Yki-J\u00e4rvinen H, Cebola I, Valenti L, den Hoed M, Romeo S. Clin Mol Hepatol. 2025 Jun 2. doi: 10.3350\/cmh.2025.0159. Online ahead of print.<\/p>\n

Protein Associations With Alcohol Consumption and Genetic Risk for Alcohol-Related Sociomedical Conditions.<\/a>\u00a0Drouard G, Palviainen T, Kuo CL, Diniz BS, Wang X,\u00a0Ollikainen M, Latvala A, Kaprio J. Addict Biol. 2025 Jun;30(6):e70045. doi: 10.1111\/adb.70045.<\/p>\n

Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration.<\/a>\u00a0Jacques M, Landen S, Sharples AP, Garnham A, Schittenhelm R, Steele J, Heikkinen A, Sillanp\u00e4\u00e4 E,\u00a0Ollikainen M, Broatch J, Zarekookandeh N, Hanson O, Ekstr\u00f6m O, Asplund O, Lamon S, Alexander SE, Smith C, Bauer C, Woessner MN, Levinger I, Teschendorff AE, Gillberg L, Blom I, Helge JW, Harvey NR, Haupt LM, Griffiths LR, Deshmukh AS, Pietil\u00e4inen KH, Piiril\u00e4 P, Seaborne RAE, Klevjer M, Bye A, Wisl\u00f8ff U, Jones-Freeman B, Eynon N. Cell Rep. 2025 Jun 24;44(6):115750. doi: 10.1016\/j.celrep.2025.115750. Epub 2025 May 28.<\/p>\n

Twin Study Provides Heritability Estimates for 2321 Plasma Proteins and Assesses Missing SNP Heritability.<\/a>\u00a0Drouard G, Hagenbeek FA,\u00a0Ollikainen M, Zheng Z, Wang X; FinnGen; Ripatti S, Pirinen M, Kaprio J. J Proteome Res. 2025 Jun 6;24(6):2689-2697. doi: 10.1021\/acs.jproteome.4c00971. Epub 2025 May 27.<\/p>\n

Pediatric heart transplantation within the Scandiatransplant region-a multinational observational study spanning 38 years.<\/a>\u00a0van der Have O, Tran-Lundmark K, W\u00e5hlander H, Kaskinen AK, M\u00f6ller T, Juul K, Jahnukainen T, Weinreich ID,\u00a0Sarkola T, Nilsson J, Odermarsky M. J Heart Lung Transplant. 2025 Jun 5:S1053-2498(25)02024-8. doi: 10.1016\/j.healun.2025.05.020. Online ahead of print.<\/p>\n

Tricaine, eugenol and etomidate for repetitive procedural anesthesia in adult zebrafish,\u00a0Danio rerio<\/em>: effect on stress and behavior.<\/a>\u00a0Narumanchi S, Perttunen S, Laine P, Kosonen R, Lakkisto P, Laine M, Tikkanen I, Paavola J. Front Vet Sci. 2025 May 14;12:1562425. doi: 10.3389\/fvets.2025.1562425. eCollection 2025.<\/p>\n

Genome-wide association study of anterior uveitis.<\/a>\u00a0Koskim\u00e4ki F, Ahokas O, Kajanne R, Saviauk KR, Elnahas A, Reigo A, Reis K, Esko T, Palta P, Leinonen S, Kettunen J, Liinamaa J, Karjalainen MK, Saarela V; Estonian Biobank Research Team Consortium, FinnGen Consortium; FinnGen Consortium. Br J Ophthalmol. 2025 May 30;109(6):660-667. doi: 10.1136\/bjo-2024-326037.<\/p>\n

Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity.<\/a>\u00a0Heikkinen A, Esser VFC, Lee SHT, Lundgren S, Hakkarainen A, Lundbom J, Kuula J, Groop PH, Heinonen S, Villica\u00f1a S, Bell JT, Maguolo A, Nilsson E, Ling C, Vaag A, Pajukanta P, Kaprio J, Pietil\u00e4inen KH, Li S,\u00a0Ollikainen M. Nat Commun. 2025 May 12;16(1):4374. doi: 10.1038\/s41467-025-59576-7.<\/p>\n

Proteomic associations with fluctuation and long-term changes in BMI: A 40-year follow-up study.<\/a>\u00a0Obeso A, Drouard G, Palviainen T, Wang X,\u00a0Ollikainen M, Silventoinen K, Kaprio J. Diabetes Obes Metab. 2025 Aug;27(8):4192-4202. doi: 10.1111\/dom.16448. Epub 2025 May 8.<\/p>\n

Multi-Omic Associations of Epigenetic Age Acceleration Are Heterogeneously Shaped by Genetic and Environmental Influences.<\/a>\u00a0Drouard G, Suhonen S, Heikkinen A, Wang Z, Kaprio J,\u00a0Ollikainen M. Aging Cell. 2025 May 5:e70088. doi: 10.1111\/acel.70088. Online ahead of print.<\/p>\n

Progression of Cerebral Small Vessel Disease Among Neurologically Asymptomatic Middle-Aged Individuals With Type 1 Diabetes.<\/a>\u00a0Tarkkonen A, Kyl\u00e4heiko I, Inkeri J, Eriksson MI, Thorn LM, Summanen PA, Tatlisumak T, Groop PH, Putaala J,\u00a0Gordin D, Martola J; FinnDiane Study Group. Diabetes Care. 2025 May 1;48(5):776-780. doi: 10.2337\/dc24-1825.<\/p>\n

Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease.<\/a>\u00a0Martiskainen H, Willman RM, Harju P, Heikkinen S, Heiskanen M, M\u00fcller SA, Sinisalo R, Takalo M, M\u00e4kinen P, Kuulasmaa T, Pekkala V, Galv\u00e1n Del Rey A, Juopperi SP, Jeskanen H, Kervinen I, Saastamoinen K; FinnGen; Niiranen M, Heikkinen SV, Kurki MI, Marttila J, M\u00e4kinen PI, Rostalski H, Hietanen T, Ngandu T, Lehtisalo J, Bellenguez C, Lambert JC, Haass C, Rinne J, Hakum\u00e4ki J, Rauramaa T, Kr\u00fcger J, Soininen H, Haapasalo A, Lichtenthaler SF, Leinonen V, Solje E, Hiltunen M. Mol Neurodegener. 2025 Apr 29;20(1):50. doi: 10.1186\/s13024-025-00830-3.<\/p>\n

Risk stratification beyond fibrosis in SLD: The case for lifestyle-responsive prognostic tools.<\/a>\u00a0\u00c5berg F, Asteljoki JV,\u00a0Luukkonen PK. J Hepatol. 2025 Aug;83(2):e91-e92. doi: 10.1016\/j.jhep.2025.04.024. Epub 2025 Apr 22.<\/p>\n

Nuclear\u00a0envelope-associated lipid droplets are enriched in cholesteryl esters and increase during inflammatory signaling.<\/a>\u00a0Szkalisity \u00c1, Vanharanta L, Saito H, V\u00f6r\u00f6s C, Li S, Isom\u00e4ki A, Tomberg T, Strachan C, Belevich I, Jokitalo E,\u00a0Ikonen E. EMBO J. 2025 May;44(10):2774-2802. doi: 10.1038\/s44318-025-00423-2. Epub 2025 Apr 7.<\/p>\n

Evidence-based criteria for identifying at-risk individuals requiring liver disease screening.<\/a>\u00a0\u00c5berg F, M\u00e4nnist\u00f6 V, Asteljoki J, Salomaa V, Jula A, Lundqvist A, M\u00e4nnist\u00f6 S, Perola M,\u00a0Luukkonen PK. Hepatol Commun. 2025 Mar 21;9(4):e0679. doi: 10.1097\/HC9.0000000000000679. eCollection 2025 Apr 1.

\nSubtypes of MASLD confer distinct clinical trajectories.<\/a>\u00a0Luukkonen PK. J Hepatol. 2025 Jun;82(6):1138-1139. doi: 10.1016\/j.jhep.2025.02.032. Epub 2025 Mar 17.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":758,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"footnotes":""},"class_list":["post-767","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/minervainstitute.fi\/fi\/wp-json\/wp\/v2\/pages\/767","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/minervainstitute.fi\/fi\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/minervainstitute.fi\/fi\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/minervainstitute.fi\/fi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minervainstitute.fi\/fi\/wp-json\/wp\/v2\/comments?post=767"}],"version-history":[{"count":85,"href":"https:\/\/minervainstitute.fi\/fi\/wp-json\/wp\/v2\/pages\/767\/revisions"}],"predecessor-version":[{"id":2754,"href":"https:\/\/minervainstitute.fi\/fi\/wp-json\/wp\/v2\/pages\/767\/revisions\/2754"}],"up":[{"embeddable":true,"href":"https:\/\/minervainstitute.fi\/fi\/wp-json\/wp\/v2\/pages\/758"}],"wp:attachment":[{"href":"https:\/\/minervainstitute.fi\/fi\/wp-json\/wp\/v2\/media?parent=767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}